Measuring normal pressures in brain veins during angiograms
Official title: Venous Sinus Pressures in Normal Individuals
Run by Wake Forest University Health Sciences · NCT03948971 · Data updated 2026-11-12
This study is trying to measure normal pressure in the brain's veins during angiograms to help doctors better understand how pressure works in the brain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Wake Forest University Health Sciences Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Winston-Salem, North Carolina) |
| Status | Recruiting |
| Started | January 13, 2020 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | May 26, 2026 |
| Trial ID | NCT03948971 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-60 who are scheduled for elective cerebral arteriography.
✕Probably not a fit
Patients with a history of intracranial venous pathology or severe headaches related to idiopathic intracranial hypertension will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to document normal intracranial venous sinus pressures in patients undergoing cerebral angiograms for unrelated medical issues. Participants will be enrolled prospectively and will undergo a standard angiogram procedure, followed by an additional intervention to measure venous pressures. This involves inserting a catheter into the internal jugular bulb and superior sagittal sinus, with minimal additional risk and time. The study seeks to gather data that could enhance understanding of intracranial pressure dynamics.
Why it matters
Potential benefit: If successful, this study could provide valuable baseline data for understanding venous pressure in the brain, potentially aiding in the diagnosis and treatment of related conditions.
How similar studies have gone: While this approach is novel in measuring normal venous sinus pressures, similar studies have successfully documented other aspects of cerebral hemodynamics.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidates for elective cerebral arteriography Exclusion Criteria: * All patients with active, or a history of, intracranial venous pathology (arteriovenous malformation, arteriovenous fistulae, idiopathic intracranial hypertension, venous sinus thrombosis). * Patients with severe daily headaches or symptoms of idiopathic intracranial hypertension will also be excluded. * Body mass index \> 35. * Known diagnosis of heart failure or pulmonary hypertension. * Pregnant women will be excluded due to the radiation risk associated with Angiogram and Venogram.
Where it's running
-
Wake Forest Univesity Health Sciences
Winston-Salem, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Kyle Fargen, MD — Wake Forest University Health Sciences
- Study coordinator: Kimberly Hawley
- Email: kimberly.hawley@advocatehealth.org
- Phone: 336-716-4031
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.