Measuring normal pressures in brain veins during angiograms
Venous Sinus Pressures in Normal Individuals
NA · Wake Forest University Health Sciences · NCT03948971
This study is trying to measure normal pressure in the brain's veins during angiograms to help doctors better understand how pressure works in the brain.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Wake Forest University Health Sciences (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Winston-Salem, North Carolina) |
| Trial ID | NCT03948971 on ClinicalTrials.gov |
What this trial studies
This research aims to document normal intracranial venous sinus pressures in patients undergoing cerebral angiograms for unrelated medical issues. Participants will be enrolled prospectively and will undergo a standard angiogram procedure, followed by an additional intervention to measure venous pressures. This involves inserting a catheter into the internal jugular bulb and superior sagittal sinus, with minimal additional risk and time. The study seeks to gather data that could enhance understanding of intracranial pressure dynamics.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-60 who are scheduled for elective cerebral arteriography.
Not a fit: Patients with a history of intracranial venous pathology or severe headaches related to idiopathic intracranial hypertension will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable baseline data for understanding venous pressure in the brain, potentially aiding in the diagnosis and treatment of related conditions.
How similar studies have performed: While this approach is novel in measuring normal venous sinus pressures, similar studies have successfully documented other aspects of cerebral hemodynamics.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidates for elective cerebral arteriography Exclusion Criteria: * All patients with active, or a history of, intracranial venous pathology (arteriovenous malformation, arteriovenous fistulae, idiopathic intracranial hypertension, venous sinus thrombosis). * Patients with severe daily headaches or symptoms of idiopathic intracranial hypertension will also be excluded. * Body mass index \> 35. * Known diagnosis of heart failure or pulmonary hypertension. * Pregnant women will be excluded due to the radiation risk associated with Angiogram and Venogram.
Where this trial is running
Winston-Salem, North Carolina
- Wake Forest Univesity Health Sciences — Winston-Salem, North Carolina, United States (RECRUITING)
Study contacts
- Principal investigator: Kyle Fargen, MD — Wake Forest University Health Sciences
- Study coordinator: Kimberly Hawley
- Email: kimberly.hawley@advocatehealth.org
- Phone: 336-716-4031
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Intracranial Venous Pressures, cerebral arteriography