Evaluating anesthesia methods in young patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the predictive value of extubation criteria in pediatric patients receiving Total Intravenous Anesthesia (TIVA) or Sevoflurane initiated intravenous anesthesia (SIIVA). It focuses on how these different anesthetic regimens, which have distinct pharmacologic mechanisms, may influence airway reflexes and ventilation during the extubation process. By examining patients under 10 years of age undergoing elective or emergency surgeries with planned airway instrumentation, the study seeks to identify optimal extubation criteria tailored to these anesthesia techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric patients \<10 years of age
* Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT)
* Patients having general anesthesia with a planned SIIVA or TIVA technique
* Patients with an end tidal agent concentration of Sevoflurane\<0.1% at the time of emergence and extubation
* following sevoflurane induction to place IV

Exclusion Criteria:

* History of home oxygen use or ventilator dependence
* Patients with cyanotic congenital heart disease
* Patients undergoing anesthesia for imaging procedures alone
* Patients intended to be managed with supraglottic airway
* Patients having an anesthesia time \< 30 minutes
* Monitored Anesthesia Care (not general anesthesia)
* Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)

Where it's running

• Atrium Health Wake Forest Baptist
  Winston-Salem, North Carolina, United States Recruiting
• Perth Children's Hospital
  Perth, Australia Not yet recruiting

Study contacts

• Principal investigator: Thomas "Wes" Templeton, MD — Wake Forest University Health Sciences
• Study coordinator: Wes Templeton, MD
• Email: ttemplet@wakehealth.edu
• Phone: 336-716-4498

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• On-hours vs off-hours extubation: comparing acute airway problems after extubation

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• Endotracheal suctioning during positive-pressure extubation in the ICU

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• Pressure-support versus T-piece breathing test for overweight and obese adults on ventilators

  This test will see if a one-hour pressure-support or T-piece breathing trial helps overweight and obese adults on a ventilator be successfully extubated without needing reintubation within 72 hours.

  Recruiting Taipei Medical University Hospital · Taipei · NCT07114289

• High-flow nasal cannula versus non-invasive ventilation after extubation in children following heart surgery

  This compares high-flow nasal cannula and non-invasive ventilation to see which better prevents reintubation in children after heart surgery.

  Recruiting Universitas Indonesia · Jakarta, DKI Jakarta · NCT07059689

• Using electrical stimulation at acupoints to reduce respiratory issues after anesthesia

  This study is testing if electrical stimulation at certain points on the body can help people recover better from anesthesia by improving their breathing and preventing problems.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT06772961

• Evaluating complications related to extubation procedures

  This study is trying to find out how often problems happen after removing breathing tubes in patients who have had surgery or are critically ill, to help make the process safer.

  Recruiting University Health Network, Toronto · Tucson, Arizona and 34 other locations · NCT06442930

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.