Sponsor or institution

Clinical trials and research at Mayo Clinic

• 511Clinical trials
• 6New in 30 days
• 14Countries

Newest trials

All recruiting trials (newest 150 of 511)

• What the Mayo Clinic is learning from blood clot tests in allergic reactions

  This study tests whether real-time blood clotting markers can help understand and predict the severity of allergic reactions and anaphylaxis in patients 12 and older.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07905911

• Atrial Arrhythmia AI-Powered Post-Ablation Predictor Pilot

  This pilot study tests whether AI models using non-invasive heart-mapping data can predict how patients with atrial arrhythmias respond after ablation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07904377

• A Community Approach to Boost Cervical Cancer Screening for Hispanic and East African Immigrant Women

  The study tests a community-based program that offers self-collection HPV tests and information to Hispanic and East African immigrant women to see if screening rates improve.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07890402

• Point-of-care AI spectroscopy test to triage vulvar lesions

  This pilot study tests whether a handheld AI-powered spectroscopy device can help triage vulvar lesions in adults who are planning surgical removal.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07886203

• Telephone follow-up by a WOC nurse after ostomy surgery

  We’re testing whether a WOC nurse’s phone check-in after ostomy surgery can reduce hospital readmissions for adults with a new ostomy.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT07879872

• Quiet Knee Protocol after knee replacement

  A randomized study tests whether a Quiet Knee Protocol after unilateral knee replacement helps with pain, range of motion, and recovery better than standard rehab.

  Recruiting Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT07879014

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• EEG-Guided TMS for Adults With Depression

  This study tests whether delivering intermittent theta burst stimulation (iTBS) timed to brain waves using EEG can improve treatment for adults with major depressive disorder who have not responded to usual antidepressants.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07862205

• Adding targeted GRID-style radiation to standard palliative therapy for unresectable solid tumors

  This study tests whether adding spatially fractionated radiation therapy to standard palliative radiation helps relieve symptoms in patients with unresectable solid tumors.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT07856394

• SMS text check-ins to track symptoms for people with plasma cell disorders

  This study tests whether daily SMS symptom prompts are feasible and acceptable for adults starting treatment for multiple myeloma or AL amyloidosis.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07850284

• Lower Body Negative Pressure to See if Noninvasive Monitors Are Accurate

  This study tests whether noninvasive physiological monitors accurately track body responses while the body experiences controlled lower body negative pressure.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07840144

• Pain Reprocessing Therapy for Functional Dyspepsia

  A small pilot test to see if a psychological therapy that uses exposure techniques can lessen digestive symptoms and help daily functioning in people with functional dyspepsia.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07838324

• See if increasing running cadence helps stress urinary incontinence in parous runners

  This study tests whether increasing running cadence by about 10% for eight weeks can reduce stress urinary incontinence symptoms in parous women who run regularly and own a Garmin watch.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07829692

• Continuous monitoring of microvascular connections: an observational study

  This study will see if the sounds from a device that watches blood flow in a free flap can be turned into a visual signal to help care teams monitor flap healing.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07823283

• Augmented Reality Guidance with Real-Time Feedback for CT-Guided Biopsy/Ablation

  This study tests whether the LUMENA guidance system can be safely used during CT-guided biopsy or ablation procedures for organs like the kidney, liver, lymph nodes, abdominal masses, and lungs.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07822425

• Noninvasive test to measure small bowel sensation using mannitol distension

  A noninvasive test using different concentrations of mannitol solution is tried in healthy people to see how their small bowel feels distension.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07817706

• Relieving a blocked pancreatic duct in chronic pancreatitis

  This pilot study tests whether clearing a blocked pancreatic duct with endoscopy can help people with chronic pancreatitis who have mild symptoms.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07810309

• Islet function in gestational diabetes: see if pancreas changes during and after pregnancy

  This study tests whether the human pancreas changes its function during and after pregnancy in people with gestational diabetes or not, using Exendin 9-39 in a small Phase 1 trial.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07806695

• See if virtual informed consent methods help people decide to join cancer research

  This trial tests whether virtual human communicators and different consent messages can influence cancer patients’ understanding and willingness to participate in research.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07805083

• Proton or Photon Radiotherapy Added to Pembrolizumab Before Surgery for Advanced or Recurrent Oral Cavity Cancer

  This phase 2 trial tests whether adding proton SFRT or SBRT to pembrolizumab before surgery helps patients with advanced or recurrent oral cavity cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07783581

• Chest-strap ECG wearable vs. traditional patch monitor in active adults

  This study tests whether the Frontier X Plus chest-strap ECG device can capture heart rhythms as well as the MoMe ARC patch in active adults who already need an ambulatory monitor.

  Recruiting at 3 sites Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07772817

• Managing Depressive Symptoms in ADPKD: testing Digital Neurotherapy and Capacity Coaching

  This study tests whether Digital Neurotherapy or Capacity Coaching can help people with ADPKD who have depression and self-reported pain, compared to education alone.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07745920

• What nurses and families think about family engagement in the Emergency Department

  This study tests how ED nurses and family members experience and describe family involvement in patient care.

  Recruiting at 3 sites Mayo Clinic · Mankato, Minnesota and 2 other locations · NCT07739576

• Community-informed approaches to equitable heart failure care in primary care

  This study tests whether engaging patients, caregivers, community health workers, and care teams can help Mayo Clinic develop equity-focused, practical care strategies for adults with congestive heart failure who face social challenges.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07730827

• Temozolomide with or without WSD0922-FU for EGFR-Mutant, IDH-Wildtype Glioblastoma

  This trial tests whether adding WSD0922-FU to temozolomide helps slow disease progression in adults with EGFR-mutant, IDH-wildtype glioblastoma.

  Recruiting at 3 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07708961

• Acute Kidney Injury in Care Transitions: A Practical Trial

  This trial tests whether a multidisciplinary care-transition program helps adults with moderate to severe AKI improve outcomes after hospital discharge.

  Recruiting Mayo Clinic · Mankato, Minnesota and 2 other locations · NCT07670520

• Flyte device to help urinary incontinence after pelvic radiation for endometrial or cervical cancer

  This study tests whether a home-use Flyte device, used during guided pelvic floor exercises, can improve urinary incontinence in women who had pelvic radiation for endometrial or cervical cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07662824

• Virtual Group Resilient Living for Advanced Cancer

  A group-based online program tests whether seven weekly sessions can reduce anxiety and fatigue and improve quality of life for adults with advanced cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07659158

• Compare two ventilator modes in adults with cardiac ICU needs and invasive ventilation

  This pilot tests whether volume-controlled versus pressure-controlled ventilation can be safely used in adults with heart disease and respiratory failure who need invasive ventilation.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07656259

• PSMA-targeted therapy with hormone suppression for low-volume metastatic prostate cancer

  This phase II trial tests leuprolide acetate alone versus with 177Lu-PSMA-617 (with or without abiraterone acetate and prednisone) in men with hormone-sensitive, low-volume metastatic prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07650240

• AAV-based gene therapy for Propionic Acidemia in young children

  This trial tests whether an AAVrh10-PCCA gene therapy can be given safely to children with Propionic Acidemia to help their bodies manage the metabolic problem.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07643844

• MenoZen VR for managing menopause symptoms

  This study tests whether MenoZen VR can help reduce hot flashes and other menopause symptoms in women aged 45–60 who have frequent hot flashes and can use a computer or smartphone at home.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07633743

• Erector Spinae Plane Block vs Trigger Point Injection for Chronic Thoracic Myofascial Pain

  A randomized trial tests whether an erector spinae plane (ESP) block or a trigger point injection (TPI) provides better relief for adults with chronic thoracic myofascial pain.

  Recruiting Phase 4 Mayo Clinic · Jacksonville, Florida and 4 other locations · NCT07632820

• Smart Symptom Tracking with ALEX for GI Health in Young Adults

  This trial tests whether the Smart Symptom Tracking ALEX app can better track GI symptoms in young adults (18–44) compared with standard paper logs.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07618273

• Physician-modified endografts for aortic disease in high-risk patients

  This study tests a physician-modified Terumo Treo abdominal stent-graft to see if it can safely treat large aortic aneurysms in patients who are high-risk for open surgery.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07611968

• Exosome-based biomarkers for cardiac sarcoidosis activity

  Researchers will test blood exosomes to see if they reveal activity of cardiac sarcoidosis in patients with and without the condition, using usual care FDG-PET data.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07604220

• Lisinopril for Secondary Polycythemia in adults

  This study tests whether the blood pressure medicine lisinopril can lower hemoglobin, hematocrit, and erythropoietin levels in adults with secondary polycythemia.

  Recruiting at 2 sites Phase 4 Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT07594535

• Shoulder replacement techniques: comparing anatomic vs. reverse in people with shoulder arthritis and a healthy rotator cuff

  This study tests whether anatomic total shoulder arthroplasty (aTSA) leads to better patient-reported outcomes after 1 year than reverse total shoulder arthroplasty (rTSA) for people with shoulder arthritis and an intact rotator cuff.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07584356

• Daily lung ultrasound to see if it shortens hospital stays for adults with acute decompensated heart failure

  This study tests whether daily lung ultrasound can shorten hospital stays and reduce readmissions for adults with acute decompensated heart failure.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07572955

• Emulsified avacopan given through a nasogastric tube for patients with ANCA-associated vasculitis and diffuse alveolar hemorrhage

  This trial will try giving emulsified avacopan (30 mg twice daily) through a nasogastric tube to up to six ventilated patients with active severe GPA or MPA and diffuse alveolar hemorrhage to see how the drug is absorbed over 72 hours.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07556484

• Remote Voice Analysis Tool to Help Diagnose and Monitor ME/CFS

  A voice-based tool is tested to help diagnose and manage myalgic encephalomyelitis/chronic fatigue syndrome in people who have the condition.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07551999

• Health and Wellness Coaching to Support Adherence in Papillary and Follicular Thyroid Cancer Survivors

  This study tests whether a patient-centered health and wellness coaching program helps adults with papillary or follicular thyroid cancer stick to treatment plans and healthy habits.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07545837

• Acceptability of DNA Markers in Vaginal Fluid for Endometrial Cancer Detection

  This study asks if Black women 45 and older with bleeding symptoms feel comfortable using vaginal fluid DNA tests to help detect endometrial cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07527143

• Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia

  This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07526766

• How to best place stimulating electrodes for the ulnar nerve in the wrist and how this compares to using anatomical landmarks

  This study tests whether lining up the stimulating electrode over the ulnar nerve using simple wrist measurements improves stimulation of the intrinsic hand muscles compared with landmark-based methods.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07515911

• VSV-IFNβ-NIS plus ipilimumab and nivolumab for advanced or metastatic clear cell renal cell carcinoma

  This trial adds a virus-based therapy (VSV-IFNβ-NIS) to standard immunotherapy (ipilimumab and nivolumab) to see if it helps people with advanced or metastatic clear cell renal cell cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07510334

• Vagal nerve stimulation plus nicotine replacement for quitting smoking

  This study tests whether adding a non-invasive vagal nerve stimulator to nicotine patches helps adults quit smoking.

  Recruiting Phase 2/3 Mayo Clinic · Rochester, Minnesota · NCT07487818

• Acoustic Resonance Therapy versus Cognitive Behavioral Therapy for Chronic Insomnia.

  This will test whether a SONU headband using Acoustic Resonance Therapy or an interactive CBT-I program helps adults with moderate-to-severe chronic insomnia sleep better after six weeks.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07486882

• Pulmonary Vascular Disease in Valvular Heart Disease: How Valve Procedures Affect Blood Flow

  This study tests how blood flow in the lungs changes in adults with left-sided valve disease who are having valve surgery and looks to see if patterns can predict reversibility of tricuspid regurgitation and right heart dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07483203

• See if spironolactone can reduce aortic stiffness in adults with thoracic aortic aneurysm

  This study tests whether spironolactone reduces aortic stiffness compared with placebo in adults with degenerative thoracic aortic aneurysms.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07483177

• Ambient sensor rooms to spot early problems in hospitalized cancer patients

  This test will try whether special hospital rooms with cameras, microphones, and temperature sensors can help staff spot early delirium, falls, sleep problems, or mood changes in adults hospitalized with cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07477886

• Retifanlimab With or Without DFMO for Progressive High-Grade Gliomas

  This trial tests whether retifanlimab, with or without DFMO, is safe and may help treat progressive high-grade gliomas in adults.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07468136

• Goserelin Injections: Is Upper-Gluteal Dosing as Good as Abdominal Dosing for OFS in Localized and Locally Advanced HR+ Breast Cancer

  This phase 2 trial tests whether giving goserelin acetate injections in the upper gluteal region works as well as abdominal injections for suppressing ovarian function in premenopausal women with localized or locally advanced hormone receptor–positive breast cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07460752

• Fluid-based PET imaging to locate ACTH-secreting pituitary adenomas in Cushing disease

  This study tests whether FET PET/CT scanning can accurately locate ACTH-secreting pituitary adenomas in adults with Cushing disease who are planning pituitary surgery.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07460232

• FET-PET/MRI to locate small hormone-producing pituitary adenomas

  This trial tests whether a special PET/MRI scan called FET-PET/MRI can find small hormone-producing pituitary adenomas in adults whose standard MRI is negative or unclear.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT07456878

• Vasodilator Therapy to Reduce Vascular Side Effects in GI Cancer Patients on Fluoropyrimidines

  This study tests whether vasodilator drugs (isossorbide mononitrate or diltiazem) or placebo can reduce blood vessel toxicity for adults with gastrointestinal cancers treated with fluoropyrimidine chemotherapy.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07456852

• Iliac crest marrow versus proximal tibia Avitus bone graft for foot and ankle procedures

  This will test whether bone graft taken from the proximal tibia with the Avitus device works as well as iliac crest bone marrow for adults needing autograft during foot or ankle fusion or nonunion surgery.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07434505

• THAM vs. sodium bicarbonate for metabolic acidosis after cardiac surgery

  This trial tests whether THAM and sodium bicarbonate perform similarly to correct metabolic acidosis in patients having heart surgery with bypass.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07424625

• ABBV-383 for relapsed or refractory Waldenström macroglobulinemia

  This phase 1/2 trial tests ABBV-383 to see if it is safe and how well it works for adults whose Waldenström macroglobulinemia has returned or not responded to treatment.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07420959

• Improved MRI methods to distinguish benign from cancerous pelvic findings

  This test tries new deep-learning image-processing methods on MRI scans to get clearer images faster for adults scanned for prostate screening or suspected endometriosis.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07407959

• How whole-fat versus low-fat milk affects adults with metabolic syndrome

  This trial will test whether drinking whole-fat milk compared with low-fat milk changes heart and metabolic risk factors and blood vessel function in adults with metabolic syndrome.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07401888

• Exercise cardiac MRI for heart failure with preserved ejection fraction

  This study will try low-field exercise cardiac MRI to see if it can diagnose, describe, and predict risk in people with HFpEF compared with those who have non-cardiac breathlessness and healthy volunteers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07401771

• Voices: sharing messages of wisdom and hope during illness

  This project will see if recording semi-structured interviews with adult cancer patients (and optional caregivers) affects patients' sense of dignity and caregiver support.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07381179

• Improving quality of life with cognitive behavioral therapy for people treated for stage III–IV melanoma

  This study will test whether cognitive behavioral therapy for cancer distress (CBT-C) helps adults treated for stage III–IV melanoma feel and function better during the first two years after treatment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07379138

• Noise-cancelling headsets to reduce sedation during knee replacement

  This study will test whether giving people having total knee replacement active noise-cancelling headphones with music or a movie during spinal anesthesia can reduce how much sedation they need.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07371390

• Breathing practices to improve brain and mental health in adolescents

  This project will try a structured breathing program to see if it helps adolescents aged 12–17 who are being treated for anxiety or mild to moderate depression.

  Recruiting at 2 sites Mayo Clinic · Albert Lea, Minnesota and 1 other locations · NCT07369752

• Health and wellness coaching to help caregivers of heart or lung transplant patients feel more confident

  This pilot will try telephonic health and wellness coaching to see if it increases confidence and reduces burden for caregivers of people awaiting heart or lung transplants.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07361159

• Mindfulness and meditation lactation education for mothers of premature NICU infants

  This will test whether mindfulness and meditation training for mothers who are pumping for their premature NICU infants changes components of their breastmilk.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07351799

• Heart disease screening with AI-enabled ECG and focused ultrasound

  This study tests whether AI-powered ECGs and focused cardiac ultrasound can screen for heart disease in well-described community groups.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07351656

• Predicting which newborns in a lower-level NICU will need extended breathing support

  This project will test whether analyzing a newborn's stomach fluid right after birth can help predict which babies born at 32+ weeks and attended by the neonatal resuscitation team will need breathing support for more than six hours.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07344714

• Intraoperative contrast-enhanced ultrasound to locate pituitary adenomas in Cushing's disease

  This pilot tests whether using contrast-enhanced ultrasound during transsphenoidal surgery helps surgeons find and remove pituitary adenomas in people with Cushing's disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07335315

• Rocklatan versus latanoprost for 24-hour eye pressure control in open-angle glaucoma and ocular hypertension

  This trial tests whether a combination eye drop (Rocklatan) lowers eye pressure over 24 hours more than latanoprost alone in adults with open-angle glaucoma or ocular hypertension.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07325240

• How doctors' behaviors affect distress during radiation therapy

  This study will see if certain physician behaviors during radiation therapy change how much distress adults with cancer experience.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07325006

• Screening to improve early detection of pancreatic cancer in high-risk adults

  This program tests whether repeated contrast-enhanced CT scans combined with blood draws and AI can find pancreatic cancer earlier in people aged 50–85 with recent-onset diabetes and a high ENDPAC score.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07324096

• Autologous dendritic cell vaccine for recurrent respiratory papillomatosis

  This test tries a vaccine made from your own dendritic cells loaded with HPV6 peptides to see if it is safe and stimulates the immune system in people with HPV6-positive recurrent respiratory papillomatosis.

  Recruiting Phase 1 Mayo Clinic · Scottsdale, Arizona · NCT07317154

• Voice features linked to pulmonary hypertension and heart disease

  This project will see if short voice recordings can show whether adults getting routine echocardiograms at Mayo Clinic have pulmonary hypertension and how severe it is.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07311044

• Deep learning to analyze and track echocardiograms

  This project will test AI tools that help clinicians read echocardiograms and flag adults who may have genetic cardiomyopathy, ischemic heart disease, or cardiac amyloidosis to see if interpretation improves and diagnoses happen faster.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07308704

• GI-102 With or Without Pembrolizumab Before Surgery for Recurrent or Progressive Grade 4 Gliomas

  The team will test whether giving GI-102 alone or together with pembrolizumab before surgery helps adults with recurrent or progressive IDH‑wildtype glioblastoma or IDH‑mutant grade 4 astrocytoma.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07301268

• Vagus nerve stimulation plus mobility training for walking recovery after chronic ischemic stroke

  This trial will test whether vagus nerve stimulation paired with mobility training can help adults who had an ischemic stroke at least six months ago improve their walking speed and stability.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07291024

• Virtual Mindfulness-Based Stress Reduction program for underserved Minnesota cancer patients

  This program tests if a virtual mindfulness-based stress reduction (MBSR) course can reduce emotional distress and improve mental well-being for cancer patients in underserved or rural parts of Minnesota.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07291011

• BLOOM: Personalized cefepime dosing for adults in the ICU

  This trial tests whether using an individualized way to pick cefepime doses based on a patient’s kidney tests helps ICU patients recover faster and have fewer side effects compared with usual dosing.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07287332

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Itraconazole for bronchiectasis with airway mold

  This study will try oral itraconazole in adults with bronchiectasis who have mold in their airways to see if people can take it safely and whether it changes symptoms and airway microbes.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07283497

• Using ultrasound microvessel imaging to evaluate ovarian and adnexal lesions

  This test tries to see if ultrasound microvessel imaging can better detect small blood vessels in adults scheduled for surgery for ovarian or adnexal lesions.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07280312

• Using MR elastography to track how manual therapy changes painful lower-back tissues

  This trial will see if a special MRI method (MR elastography) can show tissue changes in adults with chronic lower‑back myofascial pain after Tuina manual therapy compared with usual care.

  Recruiting Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT07278570

• 68Ga-FAPI-46 PET/CT to detect small bowel fibrostenosis in Crohn's disease

  This study will try whether a PET tracer called 68Ga‑FAPI‑46 can find early or developing fibrosis and strictures in the small bowel of adults with Crohn's disease.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07273188

• RNA editing to predict antidepressant response in unipolar and bipolar depression

  This project tests whether changes in RNA editing can predict how adults with unipolar or bipolar depression respond to antidepressant treatment.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07266545

• Can menopausal hormone therapy affect heart function after menopause?

  This study tests whether menopausal hormone therapy changes how the heart responds to stress in women who are past menopause.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07242391

• BMS-986340 with nivolumab plus gemcitabine and nab-paclitaxel for advanced or recurrent pancreatic adenocarcinoma

  This trial tests whether adding the antibody BMS-986340 to nivolumab together with gemcitabine and nab-paclitaxel helps people with metastatic or recurrent pancreatic adenocarcinoma.

  Recruiting at 3 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07226856

• Treating dyssynergic defecation and constipation

  This trial tests whether biofeedback therapy, with or without inspiratory muscle training, helps adults with dyssynergic defecation or chronic constipation improve bowel function.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07225803

• Heart and Voice: smartphone voice monitoring for heart health

  We will try to see if short voice recordings from adults' smartphones (and Apple Watches when available) can detect cardiovascular disease or changes in heart health.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07224685

• Prednisone after ureteroscopy with stent to reduce postoperative pain

  This study will try a short course of prednisone after ureteroscopy with a ureteral stent to reduce postoperative pain in adults with kidney or ureteral stones.

  Recruiting Phase 4 Mayo Clinic · Scottsdale, Arizona · NCT07223580

• One versus two cystic duct stents for preventing repeat gallbladder attacks

  This compares one versus two cystic duct stents to see if two stents better prevent repeat gallbladder attacks in adults who are not immediate candidates for gallbladder removal.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07222527

• Songwriting to Reduce Anxiety in Teens with Sickle Cell Disease

  This program will try songwriting and performing original songs to see if it helps reduce anxiety in adolescents (ages 11–18) with sickle cell disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07222475

• Virtual reality to reduce psychological symptom burden during cancer treatment

  This trial will try virtual reality sessions to reduce anxiety, depression, and adjustment symptoms for adults receiving cancer treatment.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07221409

• Magnetocardiography for Cardiac Amyloidosis

  This project tests whether magnetocardiography (MCG) can help diagnose and monitor heart involvement in adults with amyloidosis compared with ECG and other standard tests.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07218705

• Structured breathing to boost resilience and mental well-being in clinical care professionals

  This study will try structured breathing exercises with healthcare workers who have burnout to see if they reduce anxiety, depression, stress, and improve sleep now and over time.

  Recruiting Mayo Clinic · Albert Lea, Minnesota and 3 other locations · NCT07218458

• Tirzepatide for hot flashes and biological aging in postmenopausal women with obesity

  This trial will test whether tirzepatide reduces bothersome hot flashes and improves measures of biological aging in postmenopausal women with obesity.

  Recruiting Phase 4 Mayo Clinic · Jacksonville, Florida · NCT07218445

• Low-dose radiotherapy versus corticosteroid injection for hand and wrist osteoarthritis

  This trial will test whether low-dose radiotherapy or a corticosteroid injection works better to reduce pain for people 50 and older with hand or wrist osteoarthritis.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07217405

• Measuring heart stiffness in amyloidosis with cardiac MRI elastography

  This tests whether cardiac MRI elastography can measure heart stiffness in adults with cardiac amyloidosis compared with people without the condition.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07216469

• Personalized weight-loss medication plan for adults with bipolar disorder

  This pilot tests whether matching FDA-approved weight-loss medicines to specific obesity types helps adults aged 18–65 with bipolar disorder lose weight.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07213466

• Tracking autonomic blood-pressure changes after spinal cord injury to predict complications

  We will test whether tracking blood pressure and autonomic responses over time in adults with C6–T12 spinal cord injuries can help predict later medical complications.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07210437

• How spinal cord stimulation affects blood pressure, immune, and heart function after spinal cord injury

  This research will test whether spinal cord stimulation can change blood pressure control and immune and heart function in adults with spinal cord injury.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07210411

• Combining tissue, imaging, and genetic information to improve breast cancer risk prediction

  This research tests whether combining pathology, radiology, and genetic data can better predict future breast cancer risk for women who previously had a benign breast biopsy at Mayo Clinic.

  Recruiting at 2 sites Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT07207564

• AI-guided left bundle branch area pacing for heart failure with reduced ejection fraction

  This trial tests whether an AI-guided method for placing left bundle branch area pacing leads helps people with heart failure and reduced ejection fraction have better CRT response and clinical outcomes than conventional placement.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07206602

• Biologically-adapted, dose-escalated radiotherapy for Ewing sarcoma

  This trial tests whether giving higher radiotherapy doses tailored to tumor size and biology helps people aged 2 and older with Ewing sarcoma control their tumors better.

  Recruiting at 2 sites Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT07188532

• Stress contrast echocardiography in adults with prior SCAD

  This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07178509

• Early advance care planning education for young adults with advanced solid tumors or high-grade brain tumors

  This project will test whether short educational tools help adolescents and young adults (diagnosed at 18–39) with advanced solid tumors or high-grade brain tumors start advance care planning earlier.

  Recruiting Mayo Clinic · Scottsdale, Arizona · NCT07174661

• Tamsulosin to prevent and shorten postoperative urinary retention after spine surgery

  This trial will test whether taking tamsulosin around the time of spine surgery can reduce how often patients have urinary retention and how long it lasts.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07174349

• Cryotherapy spray (truFreeze) to eradicate gastric antral vascular ectasia.

  This will try a cryotherapy spray (truFreeze) to see if it reduces bleeding and lowers blood transfusion needs in adults with antral‑predominant GAVE and recent transfusion‑dependent anemia.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07169799

• Azithromycin versus doxycycline as atypical coverage for adults hospitalized with community-acquired pneumonia on a beta-lactam

  This trial will test whether adding azithromycin or doxycycline to a beta-lactam works better and is safer for adults hospitalized with community-acquired pneumonia.

  Recruiting Phase 4 Mayo Clinic · Scottsdale, Arizona and 4 other locations · NCT07164131

• Metyrapone for Mild Autonomous Cortisol Secretion

  This study tests whether taking metyrapone by mouth for six months can safely reduce cortisol excess in adults with MACS compared with a placebo.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07138274

• Growing immune cells outside the body to study neoantigen cancer vaccines (ACT-X)

  This project tests how immune cells from people with or without solid tumors react to a new neoantigen vaccine by collecting blood or apheresis samples.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07137312

• Genetic causes of large LDL increases after starting a ketogenic diet

  This will test whether people who start a ketogenic diet and then have very large increases in LDL cholesterol carry genetic differences in genes that affect cholesterol absorption.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07137286

• Virtual Reality support for Black men newly diagnosed with prostate cancer

  This trial tests a VR-enabled, AI-guided support tool to help Black men newly diagnosed with prostate cancer feel more supported and manage emotional and practical needs.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07126548

• How radiofrequency ablation affects esophagus stretchiness and mucosal impedance

  This study will test whether radiofrequency ablation changes how stretchy the esophagus is and the mucosal impedance in adults treated for dysplastic Barrett's esophagus.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07126535

• Virtual community health educator to boost referrals to cancer clinical programs for patients and caregivers

  This study tests whether a photo-realistic virtual community health educator can help cancer patients and their caregivers get more referrals to cancer clinical programs.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07126496

• Acceptance and Commitment Therapy to reduce cancer distress in hepatobiliary cancer patients

  This project tests if Acceptance and Commitment Therapy (ACT) helps adults with hepatobiliary cancer reduce cancer-related distress.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07124546

• Ketogenic diet for bipolar depression

  This study will try a high-fat, very low-carbohydrate (ketogenic) diet to see if it helps adults aged 18–50 with bipolar depression.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07121894

• Low-dose (1 mg) osilodrostat for mild autonomous cortisol secretion

  This trial will test whether taking 1 mg of osilodrostat daily is safe and can lower cortisol measures in adults with mild autonomous cortisol secretion.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07104812

• Early versus rescue plasma exchange for severe optic neuritis and transverse myelitis

  This trial will see if starting plasma exchange early versus using it only as a rescue after high-dose steroids improves vision for adults with severe optic neuritis and improves neurologic recovery for adults with severe transverse myelitis.

  Recruiting at 32 sites Phase 3 Mayo Clinic · Birmingham, Alabama and 34 other locations · NCT07100990

• CS reducer device for symptomatic HFpEF with coronary microvascular dysfunction

  This study will test whether implanting a coronary sinus (CS) reducer reduces heart muscle ischemia on stress CMR in adults with HFpEF and coronary microvascular dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07093528

• Using a continuous glucose monitor to manage high blood sugar in glioblastoma

  We will try continuous glucose monitors to help adults with newly diagnosed glioblastoma control high blood sugar during treatment.

  Recruiting Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT07091864

• Therapeutic plasma exchange plus enfortumab vedotin and pembrolizumab for bladder and upper urinary tract urothelial cancer

  This trial will test whether doing a therapeutic plasma exchange before giving enfortumab vedotin (an antibody‑drug conjugate) and pembrolizumab (an immune checkpoint inhibitor) helps people with metastatic or refractory urothelial (bladder or upper tract) cancer who have progressed on prior therapies.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07087860

• Inspiratory muscle training combined with cardiac rehabilitation for heart failure with reduced ejection fraction

  This trial will try inspiratory muscle training added to cardiac rehabilitation to see if it improves heart function and exercise responses in adults with heart failure and reduced ejection fraction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07086131

• 68Ga‑FAPI PET imaging to detect fibroblast activity in HFpEF

  This test uses a PET scan with 68Ga‑FAPI to see if it can identify fibroblast activity in people with HFpEF who are obese and have exertional breathlessness.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07083011

• Sonodynamic therapy using SONALA-001 or 5-ALA with MRI-guided focused ultrasound for progressive or recurrent glioblastoma

  This trial tries giving SONALA-001 (IV) or 5-ALA (oral) together with MRI-guided focused ultrasound to see if the combination is safe and can help people whose glioblastoma has progressed or come back.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07076472

• Home-based digital platform delivering sequential therapy for people with glioma

  This program will test a mobile app that helps deliver and remotely monitor home-based systemic therapy for adults with newly diagnosed or recurrent glioma.

  Recruiting at 2 sites Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT07074756

• Home versus clinic cancer treatment for Black men with advanced or recurrent prostate cancer

  This Phase II test tries whether giving cancer treatments at home instead of in the clinic is safer and more satisfying for Black men with locally advanced, biochemically recurrent, or metastatic prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07073794

• Calaspargase pegol and blood clotting in children with ALL or lymphoblastic lymphoma

  This will see if calaspargase pegol changes blood clotting or the risk of bleeding and clots in children and young adults treated for acute lymphoblastic leukemia or lymphoblastic lymphoma.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07071051

• Molecular and ctDNA profiling for high-risk endometrial cancer

  This project will collect blood and tumor tissue to test whether tumor DNA and other genetic changes can help predict recurrence in people with high-risk endometrial cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07062016

• Minibeam radiation with a tungsten slit collimator for recurrent or metastatic skin and superficial soft tissue tumors

  This trial tests whether minibeam radiation delivered through a tungsten slit collimator is safe and what dose works best for adults with recurrent or metastatic skin or superficial soft tissue tumors.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07062003

• Wearable AI to monitor heart function after lymphoma or sarcoma treatment

  This project will test whether a smartwatch-based AI ECG combined with periodic echocardiograms can find early heart damage in lymphoma or sarcoma survivors treated with anthracycline chemotherapy.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07058064

• Personalized 3D-printed external breast prosthesis after mastectomy

  This trial will try a custom 3D-printed external breast prosthesis to see if it improves patient-reported outcomes for people who had a mastectomy and did not have reconstruction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07047872

• 5-strain probiotic to prevent bone loss during aromatase inhibitor therapy

  This trial will try a 5-strain probiotic called WBF-038 to see if it prevents bone loss in people with early-stage hormone receptor–positive breast cancer who are starting aromatase inhibitor therapy.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07044310

• Robotic EMMA versus therapist-delivered lower back massage

  This test compares a robotic device called EMMA to a certified massage therapist for adults with lower back pain to see if patient experience differs.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07040397

• Minnesota RETAIN: a program to help people stay at or return to work after injury or illness

  This project will try expanding the RETAIN program in Minnesota to see if its services help injured or ill adults stay at work or return to work and reduce future workplace disability.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07037927

• Upper body fat exosome release after a meal in obesity

  This study tests how upper body fat tissue releases exosomes after eating, comparing people with obesity to those with normal weight.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07031297

• Ultrasound-guided core needle biopsy to stage bladder urothelial carcinoma

  This will try whether an ultrasound-guided core needle biopsy can accurately stage bladder urothelial carcinoma in people scheduled for radical cystectomy.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07029256

• Relugolix to improve PSMA PET/CT imaging in men with high or very high risk prostate cancer

  We are testing whether a short course of relugolix can boost PSMA levels and make PSMA PET/CT scans better at finding cancer in men with high or very high risk prostate cancer.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT07025369

• Sequenced or combined dasatinib, quercetin, fisetin, and temozolomide for adults with previously treated glioma and remaining tumor

  This trial will try different sequences or combinations of dasatinib, the plant compounds quercetin and fisetin, and the chemotherapy temozolomide to see if they are safe and help adults with previously treated glioma that still has residual tumor.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07025226

• Seizure forecasting with subscalp EEG and wearables to guide epilepsy treatment

  This trial will try using forecasts from a subscalp EEG device plus wearable data to help people with temporal-lobe focal epilepsy who have frequent disabling seizures predict and manage their seizures.

  Recruiting at 3 sites Early Phase 1 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07012148

• Understanding preserved autonomic function after multiple sclerosis

  This project will test whether people with multiple sclerosis have preserved or abnormal blood pressure and other autonomic responses compared with uninjured controls.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07012135

• AI-assisted personalized legacy program — Reflections: My Story

  This AI-assisted personalized legacy program tries to help adults with serious illness reflect on their life and create a keepsake document to share with loved ones.

  Recruiting at 2 sites Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT07009210

• Using your personal continuous glucose monitor in the hospital to improve blood sugar control

  This will try using the real-time data from your personal CGM to guide insulin while you’re hospitalized to reduce high and low blood sugars for adults with diabetes who bring a CGM.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07006480

• Longer fasting to reduce stomach contents for people on GLP‑1 medications having upper endoscopy

  This project will test whether a longer fasting period before upper endoscopy reduces stomach contents in people taking GLP‑1 receptor agonist medications.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07006142

• Collecting live tumor tissue removed during cancer surgery

  This project will collect live tumor tissue from people undergoing cancer surgery to test how tumor cells and their surrounding environment respond to treatments in the lab.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07000864

• Imaging biomarkers in corticobasal syndrome

  We will use brain imaging and blood tests to see if inflammation is linked to white-matter damage in people with corticobasal syndrome.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07000851

• Optimized ultrasound twinkling marker to image axillary lymph nodes in clinically node-positive breast cancer

  This trial tests an improved ultrasound twinkling marker to help doctors reliably see cancer-containing lymph nodes by ultrasound in people with biopsy-proven node-positive breast cancer.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT06999798

• Decitabine plus standard surgery, radiation, and chemotherapy for HPV-negative operable head and neck cancer

  This trial will test whether adding decitabine to standard surgery and radiation/chemotherapy helps people with HPV-negative head and neck cancers that can be removed by surgery.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06997094

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Mayo Clinic are recruiting right now?

511, as of November 12, 2026. 6 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (511 trials), Canada (4 trials), Iceland (2 trials), Israel (2 trials), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 64, Phase 4: 25, Phase 1: 25, Early Phase 1: 16. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →