Structured breathing to boost resilience and mental well-being in clinical care professionals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program enrolls healthcare professionals at four Mayo Clinic Health System sites who meet a Copenhagen Burnout Inventory threshold. Participants will follow a standardized breathing protocol delivered and tracked via smartphone or tablet and will be monitored for immediate and longer-term changes in anxiety, depression, perceived stress, and sleep quality. Key exclusions include recent primary psychotic or substance use disorders, significant medical or neurological conditions, chronic lung disease, and pregnancy. Symptom measures will be collected before intervention, immediately after breathing sessions, and at follow-up time points to capture both short-term and sustained effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must be healthcare professionals at the above-mentioned 4 MCHS sites (Eau Claire, La Crosse, Mankato, Albert Lea).
* Must score ≥40 on Copenhagen Burnout Inventory Q1-6.
* Participants must be physically fit enough to perform light exercise.
* Participants should read and understand English well enough to consent, complete measures, and follow instructions.
* Participants must have access to a smartphone or tablet.

Exclusion Criteria:

* Active primary psychotic disorder or substance use disorder (except nicotine dependence) within the past year.
* Severe or unstable medical condition that could interfere with participation or data collection.
* Active neurological condition (including seizure disorder, traumatic brain injury, or stroke) that could affect cognitive functioning or brain imaging results.
* Chronic lung disease (e.g., COPD, cystic fibrosis) or aneurysm.
* Current pregnancy or planning to become pregnant during the study period

Where it's running

• Mayo Clinic Health System-Eau Claire Clinic
  Eau Claire, Wisconsin, United States Recruiting
• Mayo Clinic Health System-Albert Lea
  Albert Lea, Minnesota, United States Active not recruiting
• Mayo Clinic Health System-Mankato
  Mankato, Minnesota, United States Active not recruiting
• Mayo Clinic Health System-La Crosse
  La Crosse, Wisconsin, United States Active not recruiting

Study contacts

• Principal investigator: Pravesh Sharma, MD — Mayo Clinic
• Study coordinator: Danielle Boos
• Email: boos.danielle@mayo.edu
• Phone: 715-464-8173

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.