Remote Voice Analysis Tool to Help Diagnose and Monitor ME/CFS
Official title: Use Of A Remote Voice Analysis Tool For Diagnosing And Monitoring Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS)
Run by Mayo Clinic · NCT07551999 · Data updated 2026-11-12
A voice-based tool is tested to help diagnose and manage myalgic encephalomyelitis/chronic fatigue syndrome in people who have the condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | May 26, 2026 |
| Main results expected | December 2027 |
| Study ends | July 2028 |
| Registry record updated | May 27, 2026 |
| Trial ID | NCT07551999 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a confirmed ME/CFS diagnosis by an ME/CFS specialist who can use a smartphone or tablet app and complete questionnaires.
✕Probably not a fit
Individuals without ME/CFS or without reliable access to a compatible device may not benefit from this tool.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study with no specified phase will evaluate how a smartphone-based voice recording app can aid in diagnosing ME/CFS and tracking its symptoms over time. Participants provide voice samples and complete questionnaires to see if voice data correlates with clinical features. The study is conducted at Mayo Clinic in Rochester, Minnesota, and is led by Mayo Clinic investigators. No intervention beyond voice recording is described, and results will be used to understand potential patterns in speech related to ME/CFS.
Why it matters
Potential benefit: If successful, the tool could offer a non-invasive way to support ME/CFS diagnosis and monitoring.
How similar studies have gone: Prior research in related fields suggests that voice data can reflect neurological or systemic conditions, but evidence for ME/CFS remains limited and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) verified by an ME/CFS specialist. * Ability to complete study questionnaires and provide voice samples using a smartphone application. * Consistent access to a smartphone or tablet with iOS or Android operating systems, or a laptop. Exclusion Criteria: * No diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); "Chronic Fatigue Syndrome" not verified by an ME/CFS specialist. * Lack of consistent access to a smartphone or tablet with iOS or Android operating systems, or laptop. * Known dementia or other neurodegenerative disorder prominently affecting cognition or speech patterns. outside of ME/CFS * Known history of voice disorder either primary or secondary to neuromuscular or other pathology outside of ME/CFS * Known clinically significant heart failure or greater than moderate pulmonary hypertension.
Where it's running
-
Mayo Clinic
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Stephanie L. Grach, MD, MS — Mayo Clinic
- Study coordinator: Katie Cruz
- Email: Cruz.Katie@mayo.edu
- Phone: 507-284-5404
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hyperbaric Oxygen Therapy for ME/CFS
This study tests whether hyperbaric oxygen therapy can help people with mild to moderate ME/CFS.
-
Hydrogen water to reduce fatigue and improve function in ME/CFS
This project will try hydrogen water in adults with ME/CFS to see if it reduces fatigue and improves function and whether heart rate variability can predict who benefits.
-
Using Lumbrokinase to treat Long Covid, Lyme Disease, and Chronic Fatigue Syndrome
This study is testing if a treatment called Lumbrokinase can help adults with Long Covid, Lyme Disease, and Chronic Fatigue Syndrome feel better and improve their quality of life.
-
Using vagus nerve stimulation with exercise to help chronic fatigue
This study is testing if using a special nerve stimulation along with a tailored exercise program can help people with chronic fatigue from fibromyalgia or long Covid feel better and recover faster.
-
A study using wearable devices to manage Long COVID symptoms
This study is testing if using wearable devices can help people with Long COVID manage their symptoms and improve their quality of life.
-
Monitoring fatigue in breast cancer survivors
This study is testing how fatigue affects breast cancer survivors by using smart watches and apps to track their daily activities and energy levels after treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.