Lower Body Negative Pressure to See if Noninvasive Monitors Are Accurate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers at Mayo Clinic will apply lower body negative pressure to healthy adults and measure how well noninvasive monitors reflect physiological changes. The study focuses on monitoring reliability during orthostatic stress without chronic diseases or obesity. Participants undergo specific exclusions to minimize confounding autonomic responses. The goal is to validate simple, noninvasive devices for safely tracking physiological status in stressful conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non-obese (BMI\<30)
* Non-smokers
* Free of any systemic diseases including hypertension, diabetes, coronary artery disease, neurologic disease, or any other major medical co-morbidity.
* Women will be either surgically sterilized or non-pregnant as determined by a urine pregnancy test (within 48 hours of the study day)

Exclusion Criteria:

* Individuals taking GLP-1 medications or compounds known to affect responses of the autonomic nervous system to orthostatic stress (e.g., β-blockers)
* Pregnant women

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Michael J. Joyner, MD — Mayo Clinic
• Study coordinator: Pamela Engrav
• Email: engrav.pamela@mayo.edu
• Phone: 507-255-6938

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.