THAM vs. sodium bicarbonate for metabolic acidosis after cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional Phase 4 study compares two treatments for metabolic acidosis occurring during cardiac surgery with cardiopulmonary bypass. Participants are adults undergoing cardiothoracic surgery who develop metabolic acidosis, defined by a base excess below -5, and have Minnesota Research Authorization. The study aims to determine if THAM is equivalent to sodium bicarbonate in addressing the metabolic disturbance. Mayo Clinic leads the trial at its Rochester, Minnesota site with no listed collaborators. Eligible participants are identified within the Mayo Clinic patient population and are recruited under applicable authorization and consent processes.

Why it matters

Who can join: the full rules

* Inclusion criteria

  * Cardiothoracic surgery with use of cardiopulmonary bypass
  * Presence of metabolic acidosis (defined as a base excess of \<-5)
  * Minnesota Research Authorization
* Exclusion criteria

  * Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass
  * Absence of metabolic acidosis (metabolic acidosis being defined as a base excess of \<-5)
  * Pregnant patients
  * Prisoners
  * Opt out of Minnesota Research Authorization

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Misty A. Radosevich, MD — Mayo Clinic
• Study coordinator: Nicole M. Lenort, RRT, LRT
• Email: Lenort.Nicole@mayo.edu
• Phone: 866-265-9263

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.