How radiofrequency ablation affects esophagus stretchiness and mucosal impedance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with dysplastic Barrett's esophagus receiving radiofrequency ablation will have esophageal distensibility and mucosal impedance measured during their clinically indicated upper endoscopies. Two devices will be used to obtain these measurements while the patient is sedated, adding up to about ten minutes to the procedure. Measurements will be repeated across multiple RFA sessions as Barrett's epithelium is replaced by neosquamous mucosa. The observational data will be used to explore relationships between tissue changes, treatment response, and possible complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female ≥ 18 years of age
* Confirmed histologic diagnosis of BE with dysplasia or intramucosal carcinoma (IMCa)
* Ability to take high-dose proton pump inhibitor (PPI) therapy (such as omeprazole 40 mg BID)
* Willing to undergo multiple rounds of endoscopic eradication therapy (EET) for management of BE (which is the guideline clinical recommendation for management of this disease)

Exclusion Criteria:

* History of esophageal ablation
* History of esophageal stricture
* History of esophageal or gastric surgery
* Pregnancy
* History of esophageal cancer treated with radiation or chemotherapy
* History of achalasia
* History of delayed gastric emptying confirmed by 4-hour gastric emptying study
* Received injection of glucagon like peptide 1 agonists within a few days prior to EGD
* Adults lacking the capacity to consent for self

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Chamil C Codipilly, M.D. — Mayo Clinic
• Study coordinator: Mariah J Robran
• Email: robran.mariah@mayo.edu
• Phone: (507)266-3595

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predictors of symptom improvement after laparoscopic fundoplication

  This study tests what preoperative factors help predict which GERD patients will feel better after laparoscopic fundoplication.

  Recruiting Minia University · Minya, Minya Governorate · NCT07809620

• Potassium-Competitive Acid Blockers in Barrett’s Esophagus on PPI Therapy

  This study tests whether vonoprazan, a potassium-competitive acid blocker, can better reduce acid reflux in adults with nondysplastic Barrett’s esophagus who are already taking a daily PPI.

  Recruiting Phase 4 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07788742

• Endoscopic ultrasound-guided radiofrequency ablation for pancreatic and left adrenal lesions

  This will try EUS-guided radiofrequency ablation to control symptoms and hormone-related problems in adults with small pancreatic neuroendocrine tumors (including insulinomas) or certain left adrenal adenomas.

  Recruiting Herlev Hospital · Herlev, Capital Region · NCT07272187

• Radiofrequency ablation for severe leg vein disease in people 80 and older

  This will try radiofrequency ablation in people aged 80 and older with severe chronic venous insufficiency to see if it safely closes the leaking saphenous veins and improves symptoms and quality of life.

  Recruiting Chengdu University of Traditional Chinese Medicine · Chengdu, Sichuan · NCT07233616

• Radiofrequency ablation for benign or indeterminate thyroid nodules and low‑risk papillary thyroid cancer

  This project sees if radiofrequency ablation shrinks benign or indeterminate thyroid nodules and controls low‑risk papillary thyroid cancer in adults, and how the treatment affects patients' quality of life.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07140757

• Detecting Barrett's Esophagus with a Non-Endoscopic Device

  This study is testing a new capsule device that collects cells from the esophagus to see if it can effectively detect Barrett's Esophagus in people at high risk, without needing an endoscopy.

  Recruiting Cyted Health Inc · Cordova, Tennessee · NCT06803927

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.