Sequenced or combined dasatinib, quercetin, fisetin, and temozolomide for adults with previously treated glioma and remaining tumor

Inclusion Criteria - Treatment Arm (Regimens 1-8):

* Age ≥ 18 years
* Prior diagnosis of a glioma treated with chemotherapy and/or radiation with stable disease based on Response Assessment in Neuro-Oncology (RANO) criteria

  * Must have IDH-mutant OR MGMT-methylated glioma

    * NOTE: Patients with any radiographic evidence of residual disease are eligible
* Eastern Cooperative Oncology Group (ECOG) of 0, 1, or 2, and Karnofsky performance status \>= 50
* Hemoglobin ≥ 9.0 g/dL (≤ 15 days prior to registration)
* Absolute neutrophil count (ANC) ≥ 1500/mm\^3 (≤ 15 days prior to registration)
* Platelet count ≥ 100,000/mm\^3 (without transfusion ≤ 7 days preceding lab assessment) (≤ 15 days prior to registration)
* Alanine aminotransferase (ALT) and aspartate transaminase (AST) ≤ 2.5 x upper limit of normal (ULN) (or ≤ 5 x ULN for patients with liver involvement) (≤ 15 days prior to registration)
* Calculated creatinine clearance ≥ 45 ml/min using the Cockcroft-Gault formula (≤ 15 days prior to registration)
* Average corrected QT interval (QTc) ≤ 450 ms on triplicate 12 lead electrocardiogram (ECG) ≤ 29 days prior to registration

  * NOTE: QTc intervals will be corrected using Fridericia's formula (Fridericia 1920)
* Negative serum pregnancy test is required for persons of childbearing potential ≤ 8 days prior to registration
* Presence of an implanted cranial CSF access device, such as Ommaya reservoir or ventriculoperitoneal shunt
* Willingness to provide blood and CSF samples for research
* Co-enrollment on the neuro-oncology biorepository \[institutional review board (IRB) 12-003458\] for collection of research blood and CSF samples
* Provide written informed consent
* Willingness to return to Mayo Clinic for follow-up

Inclusion Criteria - Monitoring Arm (Regimen 1 only):

* Age ≥ 18 years
* Prior diagnosis of a glioma
* Negative serum pregnancy test is required for persons of childbearing potential ≤ 8 days prior to registration
* Co-enrollment on the neuro-oncology biorepository \[institutional review board (IRB) 12-003458\] for collection of research blood and CSF samples
* Provide written informed consent
* Willingness to return to Mayo Clinic for follow-up

Exclusion Criteria - Treatment Arm (Regimens 1-8):

* Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects:

  * Pregnant persons
  * Nursing persons
  * Persons of childbearing potential and persons able to father a child who are unwilling to employ adequate contraception
* Patients who are not appropriate medical candidates due to current or past medical history or uncontrolled concurrent illness which limits safety of or compliance to study proceedings
* Participants who are unable to swallow tablets or who are at risk for impaired absorption of oral medication

  * NOTE: This includes but not limited to, refractory vomiting, gastric resection/bypass, or duodenal/jejunal resection
  * NOTE: An exception can be granted for such patients if no oral medications are planned (i.e., patient will receive only IV or intradermal agents)
* Patients with known hypersensitivity or allergy to all of the study drugs on the protocol (known hypersensitivity or allergy to one drug does not preclude participation in this protocol)
* Inability to undergo MRI scans

  * NOTE: These patients may be enrolled in the Monitoring Arm

Exclusion Criteria - Monitoring Arm (Regimen 1 only):

* Any of the following because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects:

  * Pregnant persons
  * Nursing persons
  * Persons of childbearing potential and persons able to father a child who are unwilling to employ adequate contraception
* Current or past medical history or uncontrolled concurrent illness which limits safety or compliance with study proceedings
* Known hypersensitivity or allergy to radioactive tracers
* Inability to undergo clinical imaging