Collecting live tumor tissue removed during cancer surgery
Official title: Predicting Response to Therapy From Analysis of Live Tumor Fragments of Surgical Resections
Run by Mayo Clinic · NCT07000864 · Data updated 2026-11-12
This project will collect live tumor tissue from people undergoing cancer surgery to test how tumor cells and their surrounding environment respond to treatments in the lab.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | June 1, 2028 |
| Study ends | June 1, 2028 |
| Registry record updated | May 22, 2026 |
| Trial ID | NCT07000864 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults who can give informed consent and are planning to have surgical removal of a cancerous tumor at the enrolling site with tissue available for research.
✕Probably not a fit
Patients who are not having surgery, who cannot provide consent, or whose resected tissue is unavailable or insufficient for research are unlikely to be helped by participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project collects unused tumor fragments from surgical resections along with linked clinical data. Samples are kept viable and analyzed ex vivo using genomic, proteomic, and imaging techniques to study treatment responses and the integrity of the tumor microenvironment. No treatments are given to participants; analyses are performed in the lab to characterize biological features and how they change when exposed to therapies. Results aim to build datasets that could correlate ex vivo behavior with patient outcomes to inform future translational research.
Why it matters
Potential benefit: If successful, this work could help researchers identify which treatments are most likely to work for certain tumors and accelerate development of personalized therapies.
How similar studies have gone: Related ex vivo tumor explant and organoid studies have shown promise in predicting drug responses in preclinical and early clinical settings, but these approaches are not yet standard clinical practice.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ability to understand and sign informed consent * Planning to undergo a surgical procedure to remove cancer Exclusion Criteria: * Does not meet Inclusion criteria * No tissue for research available at time of surgery
Where it's running
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Mayo Clinic in Florida
Jacksonville, Florida, United States Recruiting
Study contacts
- Principal investigator: Debabrata Mukhopadhyay, PhD — Mayo Clinic
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.