Collecting live tumor tissue removed during cancer surgery
Predicting Response to Therapy From Analysis of Live Tumor Fragments of Surgical Resections
This project will collect live tumor tissue from people undergoing cancer surgery to test how tumor cells and their surrounding environment respond to treatments in the lab.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Trial ID | NCT07000864 on ClinicalTrials.gov |
What this trial studies
This observational project collects unused tumor fragments from surgical resections along with linked clinical data. Samples are kept viable and analyzed ex vivo using genomic, proteomic, and imaging techniques to study treatment responses and the integrity of the tumor microenvironment. No treatments are given to participants; analyses are performed in the lab to characterize biological features and how they change when exposed to therapies. Results aim to build datasets that could correlate ex vivo behavior with patient outcomes to inform future translational research.
Who should consider this trial
Good fit: Ideal candidates are adults who can give informed consent and are planning to have surgical removal of a cancerous tumor at the enrolling site with tissue available for research.
Not a fit: Patients who are not having surgery, who cannot provide consent, or whose resected tissue is unavailable or insufficient for research are unlikely to be helped by participation.
Why it matters
Potential benefit: If successful, this work could help researchers identify which treatments are most likely to work for certain tumors and accelerate development of personalized therapies.
How similar studies have performed: Related ex vivo tumor explant and organoid studies have shown promise in predicting drug responses in preclinical and early clinical settings, but these approaches are not yet standard clinical practice.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ability to understand and sign informed consent * Planning to undergo a surgical procedure to remove cancer Exclusion Criteria: * Does not meet Inclusion criteria * No tissue for research available at time of surgery
Where this trial is running
Jacksonville, Florida
- Mayo Clinic in Florida — Jacksonville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Debabrata Mukhopadhyay, PhD — Mayo Clinic
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.