Azithromycin versus doxycycline as atypical coverage for adults hospitalized with community-acquired pneumonia on a beta-lactam

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 4 interventional trial compares two commonly used antibiotics (azithromycin and doxycycline) given alongside a beta-lactam in adults hospitalized with community-acquired pneumonia. Eligible patients are adults admitted with CAP who receive a beta-lactam plus either azithromycin or doxycycline within 12 hours of admission. Key exclusions include high suspicion for Legionella, severe CAP, QT prolongation, pregnancy, receipt of other antibiotics like quinolones, admission >24 hours, and prisoners. The trial will measure clinical effectiveness and safety outcomes during the hospital course at Mayo Clinic sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.

Exclusion Criteria:

* High clinical suspicion for Legionella pneumonia
* Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
* Antibiotics not for CAP
* Pregnant women (based on clinical assessment as part of standard of care)
* Severe CAP as defined by the ATS/IDSA criteria
* Corrected QT prolongation (\> 450 ms in men and \> 460 ms in women)
* Incarcerated individuals (prisoner)

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting
• Mayo Clinic in Arizona
  Scottsdale, Arizona, United States Not yet recruiting
• Mayo Clinic in Florida
  Jacksonville, Florida, United States Not yet recruiting
• Mayo Clinic Health System-Mankato
  Mankato, Minnesota, United States Not yet recruiting
• Mayo Clinic Health System-La Crosse
  La Crosse, Wisconsin, United States Not yet recruiting

Study contacts

• Principal investigator: Ognjen Gajic, MD MS — Mayo Clinic
• Study coordinator: Amy Amsbaugh, RRT
• Email: amsbaugh.amy@mayo.edu
• Phone: 5075387538

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.