Prednisone after ureteroscopy with stent to reduce postoperative pain
Official title: Evaluating The Role Of Corticosteroids In Post-Ureteroscopy Recovery For Urinary Calculi
Run by Mayo Clinic · NCT07223580 · Data updated 2026-11-12
This study will try a short course of prednisone after ureteroscopy with a ureteral stent to reduce postoperative pain in adults with kidney or ureteral stones.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Drugs / interventions | prednisone |
| Locations | 1 site (Scottsdale, Arizona) |
| Status | Recruiting |
| Started | January 23, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | February 3, 2026 |
| Trial ID | NCT07223580 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) having ureteroscopy with ureteral stent placement who can give informed consent and are not on chronic opioids or current corticosteroids are ideal candidates.
✕Probably not a fit
Patients with chronic pain conditions, long-term opioid use, current corticosteroid therapy, bilateral ureteroscopy, pregnancy, or insulin-dependent diabetes are excluded and unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing ureteroscopy with placement of a ureteral stent for kidney or ureteral stones will be enrolled. Participants will receive either a short course of oral prednisone or a matching placebo in addition to standard postoperative pain medications. Pain scores and analgesic use will be tracked after surgery to compare postoperative pain control between groups. Key exclusions include chronic pain, chronic opioid use, current corticosteroid use, bilateral procedures, pregnancy, and insulin-dependent diabetes.
Why it matters
Potential benefit: If successful, this could reduce postoperative pain and lower the need for opioid pain medicines after ureteroscopy.
How similar studies have gone: Perioperative corticosteroids have shown pain- and opioid-sparing effects in some other surgical settings, but evidence specifically for use after ureteroscopy with stent placement is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are diagnosed with kidney or ureteral stones confirmed on imaging (CT of the abdomen or pelvis) and who elect for definitive treatment via ureteroscopy with placement of ureteral stent. * Age 18 years or older * Patients of either gender * Patients of all ethnic backgrounds * Cable of giving informed consent * Capable and willing to fulfill the requirements of the study. Exclusion Criteria: * History of chronic pain * Chronic use of opioids or other pain medication (\>12 weeks) * Known allergies to corticosteroids. * Known or suspected pregnancy * Inability to give informed consent or unable to meet requirements of the study for any reason. * Bilateral ureteroscopy * Current Corticosteroid Use * Diabetic patients who are insulin dependent
Where it's running
-
Mayo Clinic in Arizona
Scottsdale, Arizona, United States Recruiting
Study contacts
- Principal investigator: Karen L. Stern, MD — Mayo Clinic
- Study coordinator: Rev V. Vilasan Shylaja
- Phone: 480-574-1466
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.