Shoulder replacement techniques: comparing anatomic vs. reverse in people with shoulder arthritis and a healthy rotator cuff
Official title: A Randomized Trial Comparing Anatomic And Reverse Total Shoulder Replacement For Shoulder Arthritis With An Intact Rotator Cuff
Run by Mayo Clinic · NCT07584356 · Data updated 2026-11-12
This study tests whether anatomic total shoulder arthroplasty (aTSA) leads to better patient-reported outcomes after 1 year than reverse total shoulder arthroplasty (rTSA) for people with shoulder arthritis and an intact rotator cuff.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years to 85 Years |
| Sex | All |
| Enrollment | 108 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | May 5, 2026 |
| Main results expected | July 2029 |
| Study ends | December 2029 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07584356 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with shoulder arthritis and an intact rotator cuff, and glenoid retroversion less than 25°, eligible for either aTSA or rTSA.
✕Probably not a fit
Patients with rotator cuff insufficiency, significant glenoid deformities, infection, or conditions interfering with follow-up may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two shoulder replacement techniques in adults with shoulder arthritis and an intact rotator cuff. Participants will receive either anatomic total shoulder arthroplasty (aTSA) or reverse total shoulder arthroplasty (rTSA) and will be followed to assess patient-reported outcomes at 12 months. The trial is conducted at Mayo Clinic in Rochester, with inclusion criteria focusing on preserved rotator cuff function and limited glenoid retroversion; key exclusion criteria include rotator cuff insufficiency, fracture deformities, infection, certain glenoid deformities, and language or follow-up barriers. Outcomes will be driven by patient-reported measures to determine if one method provides superior functional and quality-of-life results.
Why it matters
Potential benefit: If successful, patients and clinicians may choose the technique that provides better function and satisfaction after shoulder replacement.
How similar studies have gone: Prior research in shoulder arthroplasty has explored outcomes for aTSA versus rTSA, with mixed results; this study adds direct comparison in a specific cuff-intact population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Shoulder arthritis * Intact rotator cuff * Glenoid retroversion less than 25° Exclusion Criteria * Rotator cuff insufficiency * Fracture deformity/sequelae * Severe glenoid deformity (C glenoid, severe A2, B2 glenoid) * Current or previous infection of shoulder * Previous acromion fracture (not os acromiale) * Brachial plexopathy * Axillary neuropathy * Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * Inability or unwillingness of individual or legal guardian/representative to give written informed consent. * Medical conditions that would make 2 years follow up unlikely * Non-English speaking
Where it's running
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Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Jonathan D. Barlow, MD — Mayo Clinic
- Study coordinator: Lucille I Anderson, CCRP
- Email: anderson.luci@mayo.edu
- Phone: 507-538-5627
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.