Noninvasive test to measure small bowel sensation using mannitol distension
Official title: Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test
Run by Mayo Clinic · NCT07817706 · Data updated 2026-11-12
A noninvasive test using different concentrations of mannitol solution is tried in healthy people to see how their small bowel feels distension.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | June 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | October 2, 2026 |
| Trial ID | NCT07817706 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults without current GI symptoms or history of GI disorders who can consent and participate in study procedures.
✕Probably not a fit
Individuals with active GI disorders, prior bowel surgery (except appendectomy or cholecystectomy), or those taking medications affecting bowel function may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to establish normative responses to small bowel distension by giving participants solutions of mannitol at three concentrations and using scintigraphy. It will identify the symptom range generated by these distensions in individuals without gut-brain interaction disorders. The trial has specific inclusion criteria to enroll healthy volunteers and exclusion criteria to avoid confounding factors such as existing GI issues or medications affecting bowel function. Mayo Clinic leads the study at its Rochester, MN site. The results could help define baseline small bowel sensation in preparation for future research in patients with DGBI.
Why it matters
Potential benefit: If successful, the study could provide baseline data on normal small bowel sensation to aid future research and potentially improve diagnostic approaches for DGBI.
How similar studies have gone: Prior work in related GI sensing has established normative responses in healthy subjects, supporting the feasibility of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * No current gastrointestinal symptoms * No prior history of GI disorders, in particular DGBIs * Ability to provide informed consent * Ability to participate in study procedures * Absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results * For females, must not be pregnant or lactating due to radiation exposure. * Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control are permissible. Exclusion Criteria * Subjects on any medications that impact transit or integrity of small bowel mucosal barrier (e.g. chronic NSAIDS) of the GI tract will be excluded. * Patients with prior bowel surgery (not including appendectomy and cholecystectomy) * Patients who may have altered sensation (central sensitization or conditions that may induce bowel hyperalgesia) based on PI review of medical history (ie, fibromyalgia, endometriosis, chronic pelvic pain)
Where it's running
-
Mayo Clinic
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Xiao Jing Wang, MD — Mayo Clinic
- Study coordinator: Taylor Hines
- Email: hines.taylor@mayo.edu
- Phone: 507-538-9959
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.