Can menopausal hormone therapy affect heart function after menopause?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares left ventricular stroke volume and heart rate responses to bursts of sympathetic nerve activity in menopausal women who use menopausal hormone therapy versus those who do not. Participants are women over 45 years who are postmenopausal and meet specific health criteria. Data are collected at Mayo Clinic in Rochester to explore whether hormone therapy influences cardiac responses in this population. The study does not involve new treatments beyond the existing use of menopausal hormone therapy. Results may help clarify potential cardiovascular effects of hormone therapy after menopause.

Why it matters

Who can join: the full rules

Inclusion Criteria

• \>45-60\< years of age

Exclusion Criteria

* Male sex
* Females between STRAW+10 stages -5 and 0
* PMF in STRAW+10 stage +2
* PMF using oral hormone therapy
* Females who entered menopause due to a surgical procedure or in response to pharmacotherapy (e.g., gonadotrophin releasing hormone agonists or chemotherapy)
* Heart disease such as hypertropic cardiomyopathy, congenital abnormalities, chronic heart failure, valve disease, and a history of myocardial infarction
* Medications that impact the central nervous system including selective serotonin reuptake inhibitors, anxiolytics, sedatives, anticholinergic agents, dopamine, amphetamines, or wake-promoting agents (e.g., modafinil). Other medications will be evaluated on an individual basis by the PI.
* Cardiovascular medications is also an exclusion criterion which includes those acting on the renin-angiotensin-aldosterone axis, adrenergic receptor antagonists, diuretics, nitrates, and calcium channel antagonists. Other medications will be evaluated on an individual basis by the PI.
* Pregnancy
* COPD
* Diabetes
* CKD
* Raynaud's phenomenon
* Sleep disorders
* Shift workers
* BMI ≥40.0kg/m2
* Use of nicotine-containing products within the two years preceding study visits
* Active cancer treatment

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Joshua Bock, Ph.D. — Mayo Clinic
• Study coordinator: Joshua Bock, Ph.D.
• Email: bock.joshua@mayo.edu
• Phone: 507-422-0768

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.