Atrial Arrhythmia AI-Powered Post-Ablation Predictor Pilot
Official title: Pilot Observational Study for the Development of an Artificial Intelligence-Driven Methodology to Identify Optimal Atrial Ablation Strategies Using Non-Invasive Electrocardiographic Imaging (ACORYS-AI4AF Pilot Study)
Run by Mayo Clinic · NCT07904377 · Data updated 2026-11-12
This pilot study tests whether AI models using non-invasive heart-mapping data can predict how patients with atrial arrhythmias respond after ablation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | January 28, 2026 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT07904377 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with paroxysmal AF, persistent AF, or atrial flutter who are planned for catheter ablation and can consent.
✕Probably not a fit
Patients not undergoing ablation or those without suitable mapping data may have little or no direct benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational pilot uses the Acorys Mapping System to collect non-invasive electrophysiological data from adults with atrial arrhythmias undergoing ablation. The study aims to develop and evaluate the ACORYS-AI4AF model to forecast post-ablation outcomes based on mapping information. Enrollment includes adults with paroxysmal or persistent atrial fibrillation or atrial flutter, with eligibility tied to clinical indication for ablation and consent ability. Data collection is observational and centers on AI model development rather than therapeutic testing. The study is sponsored by Mayo Clinic with Corify Care as a collaborator and conducted at Mayo Clinic in Rochester, MN.
Why it matters
Potential benefit: If successful, the AI model could help predict which patients are more likely to have favorable ablation results and tailor follow-up strategies.
How similar studies have gone: Previous work in non-invasive mapping and AI-based prediction for ablation outcomes has shown promise, but this specific ACORYS-AI4AF pilot is relatively novel in its approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Age ≥ 18 years old * Diagnosis of paroxysmal AF, persistent (including longstanding) AF or atrial flutter o Definition of persistent AF per the 2023 AHA/ACC/HRS Guidelines: AF that is continuous and sustains for \>7 d and requires intervention. Of note, patients with persistent AF who, with therapy, become paroxysmal should still be defined as persistent. * Clinical indication for catheter ablation per SOC. * Demonstrated willingness and ability to adhere to the study protocol, including provision of written informed consent Exclusion Criteria * Age \<18 years old * Pregnancy or lactation * Contraindications for catheter ablation * Prior surgical/Convergent Ablation * 2 or more prior PVIs * Typical atrial flutter as the only clinical arrhythmia (anticipated cavotricuspid isthmus ablation only) * Contraindications to use of the ACORYS Mapping System, such as open wounds, skin conditions, or known material sensitivities, including sensitivities to acrylic adhesives or silver * Participation in another clinical trial that would interfere with study outcome
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Konstantinos Siontis, M.D — Mayo Clinic
- Study coordinator: Brooke Stanga
- Email: stanga.brooke@mayo.edu
- Phone: 507-422-6692
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Volta AI software in real-world AF ablation
A real-world observational study will test the latest Volta AF-Xplorer II AI software during atrial fibrillation ablation to see how safe and effective it is over 24 months.
-
AV node ablation with left bundle branch area pacing versus right ventricular pacing for atrial fibrillation with preserved heart function
This test checks whether left bundle branch area (LBBA) pacing instead of right ventricular (RV) pacing after AV node ablation better preserves heart function in adults with symptomatic atrial fibrillation and normal ejection fraction.
-
Acquiring 2D ICE Images with the CHORUS IDx System During Atrial Arrhythmia Ablation
This study tests whether the CHORUS IDx system can acquire 2D intracardiac echocardiography images during an ablation for atrial arrhythmias.
-
Using the VERAFEYE imaging and navigation system to guide catheter ablation for atrial arrhythmias
This study will try the VERAFEYE imaging and guidance system during catheter ablation in adults with atrial flutter or atrial fibrillation to see if it integrates well with standard procedures.
-
Anatomical navigation to guide catheter ablation for atrial fibrillation and flutter
This trial will test whether the VERAFEYE Anatomical Guidance System helps doctors guide catheter ablation in adults with atrial fibrillation or atrial flutter.
-
Ablation and Isolation for Persistent Atrial Fibrillation Treatment
This study is testing a new two-step treatment for long-lasting atrial fibrillation to see if it works better than the standard method and helps patients need fewer medications.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.