Longer fasting to reduce stomach contents for people on GLP‑1 medications having upper endoscopy
Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists
This project will test whether a longer fasting period before upper endoscopy reduces stomach contents in people taking GLP‑1 receptor agonist medications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT07006142 on ClinicalTrials.gov |
What this trial studies
The trial applies a modified fasting protocol for patients taking GLP‑1 receptor agonists who are scheduled for elective upper endoscopy. Gastric residual volume will be measured during endoscopy to determine if prolonged fasting lowers the amount of stomach contents. The goal is to identify a fasting approach that reduces aspiration risk and can be agreed on by perioperative care teams. The protocol excludes urgent procedures and patients with conditions that affect gastric emptying.
Who should consider this trial
Good fit: Adults taking GLP‑1 receptor agonists who are scheduled for elective upper endoscopy with the gastroenterology team and can provide their own consent are ideal candidates.
Not a fit: Patients having urgent procedures, those with known motility disorders (like gastroparesis or achalasia), recent upper GI barium studies, pancreatitis, use of pro‑motility drugs, or procedures that include colonoscopy or enteroscopy are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this could lower the risk of aspiration during anesthesia and create clearer fasting guidance for patients on GLP‑1 medications.
How similar studies have performed: There is limited prior trial data—GLP‑1 receptor agonists are known to slow gastric emptying, but few controlled studies have tested changing fasting times, so the approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing elective upper endoscopy with gastroenterology team Exclusion Criteria: * Urgent or emergent procedure * Inclusion of colonoscopy or antegrade small bowel enteroscopy in planned procedure * Upper GI barium study performed in past 24 hours. * Gastroparesis * Achalasia * Pancreatitis * Use of outpatient pro-motility medications * Patient refusal * Inability for patient to provide own consent
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Study coordinator: Krishnan Ramanujan, MD
- Email: ramanujan.krishnan@mayo.edu
- Phone: 507-422-4898
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.