Pulmonary Vascular Disease in Valvular Heart Disease: How Valve Procedures Affect Blood Flow

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will characterize pulmonary hemodynamics, especially pulmonary vascular resistance subtypes, in adults with left-sided valvular heart disease undergoing aortic or mitral valve procedures. Echocardiography will be used to collect data on heart pressures and function before and after intervention. The goal is to identify patterns that predict whether tricuspid regurgitation and right ventricular dysfunction may improve following valve surgery. Conducted at Mayo Clinic in Rochester, the study will help clarify how valve interventions impact pulmonary circulation and right heart performance. Participation is limited to adults scheduled for valve procedures with standard exclusions to ensure safe and complete data collection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18 years old; AND
* Scheduled for valve procedures

Exclusion Criteria:

* Congenital heart disease (except for bicuspid aortic valve), OR
* Carcinoid heart disease, OR
* Valvular mass, OR
* Endocarditis, OR
* Any other condition that, in the opinion of the investigator, would impair their ability to complete the study

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Barry Borlaug, MD — Mayo Clinic
• Study coordinator: Annabelle Fuenffinger
• Email: fuenffinger.annabelle@mayo.edu
• Phone: 507-422-3801

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Impact of ambient air vs nasal liquid oxygen on exercise performance in pulmonary vascular disease

  This study tests whether using nasal liquid oxygen during a 6-minute walk test changes how far patients with PAH or CTEPH can walk compared to breathing room air.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07777445

• Liquid oxygen vs ambient air during a 6-minute walk in people with pulmonary vascular disease

  This study tests whether walking with liquid oxygen at about 4 L/min helps or hinders distance walked compared with walking on room air in adults with PAH or CTEPH living in Switzerland.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07777367

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• Heart sound signals to detect valve and artery disease early

  This observational study tests whether a new digital stethoscope-like device can pick up heart sound patterns to detect valvular or coronary artery disease earlier in people who are already getting heart imaging.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07496775

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• MMVD: A Multicenter Registry to Understand Multiple and Mixed Valvular Heart Disease

  This study tests how common MMVD is, what imaging and management practices are used, and what factors influence outcomes in adults with two or more valve issues.

  Recruiting at 2 sites French Cardiology Society · Lille and 1 other locations · NCT07176507

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.