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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Heart and Voice: smartphone voice monitoring for heart health

Official title: Evaluation of Voice and ECG Transmission and AI Models Using Voice, ECG and Health Data Collected Using a Mayo Clinic Center for Digital Health (CDH)-Developed App for a Repository: Mayo Clinic CV Research for Heart & Voice Study

Run by Mayo Clinic · NCT07224685 · Data updated 2026-11-12

We will try to see if short voice recordings from adults' smartphones (and Apple Watches when available) can detect cardiovascular disease or changes in heart health.

More Cardiovascular Diseases trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000000 (estimated)
SponsorMayo Clinic
Academic / other
Locations1 site (Rochester, Minnesota)
StatusRecruiting
StartedMarch 5, 2024
Main results expectedMarch 2029
Study endsMarch 2029
Registry record updatedNovember 5, 2025
Trial IDNCT07224685 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult Mayo Clinic patients who are interested, can sign HIPAA authorization, and who use the Mayo patient iPhone app on iOS 14+ with an Apple Watch v4+ (not SE), or who have an Android phone capable of recording voice.

Probably not a fit

People under 18, those without a compatible smartphone or unwilling to share voice data or HIPAA authorization, and individuals whose voice recordings are unusable (for example due to severe voice disorders) may not receive benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project enrolls consenting Mayo Clinic patients who provide voice recordings using their own iPhone (iOS 14+) or Android device and may pair Apple Watch v4+ data when available. Recorded voice signals will be processed with signal‑processing and machine‑learning methods to identify features associated with cardiovascular disease, wellness, or elevated health risk. There is no drug or procedure intervention; the study collects remote digital data with signed HIPAA authorization. Researchers will compare voice-derived features to clinical information in the medical record to determine correlations with heart health.

Why it matters

Potential benefit: If successful, this could offer a low-cost, noninvasive way to monitor heart health remotely and alert people who need clinical follow-up.

How similar studies have gone: Prior exploratory studies have shown promising links between voice features and cardiopulmonary conditions, but the approach remains experimental and not yet validated for routine clinical use.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Adult patients using the Mayo patient iPhone app and iOS 14.0 or later (determined automatically via Mayo software) and Apple Watch v 4 or later (not SE), or if they have Android device for voice
* Expressed interest in participation
* Signed HIPPA authorization

Exclusion Criteria:

• Age under 18

Where it's running

  • Mayo Clinic in Rochester
    Rochester, Minnesota, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.