Stress contrast echocardiography in adults with prior SCAD
Official title: Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography
Run by Mayo Clinic · NCT07178509 · Data updated 2026-11-12
This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | November 25, 2025 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | January 7, 2026 |
| Trial ID | NCT07178509 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with a prior history of SCAD or healthy adults with no significant medical history who can undergo dobutamine/atropine stress and receive Definity® contrast are ideal candidates.
✕Probably not a fit
People who are pregnant, cannot stop breastfeeding, have had a recent heart attack, have severe aortic stenosis or uncontrolled hypertension, or who are allergic to the study agents are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational protocol uses dobutamine (and, if needed, atropine) stress combined with an ultrasound contrast agent to image myocardial microvascular perfusion and record pressor responses. Participants will include adults with a history of SCAD and healthy adult controls without major medical problems. The exam documents contrast enhancement patterns and hemodynamic responses during pharmacologic stress to identify perfusion abnormalities or exaggerated blood-pressure responses. Exams are performed at Mayo Clinic in Rochester, Minnesota, with standard safety exclusions such as recent MI, severe aortic stenosis, pregnancy, uncontrolled hypertension, or known hypersensitivity to agents used.
Why it matters
Potential benefit: If successful, the findings could help identify abnormal small-vessel blood flow or pressor patterns after SCAD that inform follow-up care and targeted management strategies.
How similar studies have gone: Contrast stress echocardiography has been used successfully to study microvascular perfusion in other cardiac conditions, but applying it specifically to patients with prior SCAD is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult \>18 years old * Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history Exclusion Criteria: * Unable to give consent * Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine. * Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®. * Pregnant. * Unable to interrupt breastfeeding. * Within 3 months of a heart attack. * Severe aortic stenosis. * Severe, uncontrolled hypertension (\>200/110 mmHg at baseline).
Where it's running
-
Mayo Clinic
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Marysia Tweet, M.D., M.S. — Mayo Clinic
- Study coordinator: Pamela Engrav
- Email: engrav.pamela@mayo.edu
- Phone: 507-255-6938
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.