Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia
Official title: Cardiopulmonary, Hemodynamic, And Symptom Responses To Aerobic And Resistance Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia: A Single-center, Single-arm Prospective Clinical Trial.
Run by Mayo Clinic · NCT07526766 · Data updated 2026-11-12
This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 65 Years |
| Sex | All |
| Enrollment | 28 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | August 30, 2027 |
| Study ends | November 1, 2027 |
| Registry record updated | October 22, 2026 |
| Trial ID | NCT07526766 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a history of SCAD and/or FMD who are at least two months post-event, free of chest pain, able to exercise, and able to give informed consent are ideal candidates.
✕Probably not a fit
People who are clinically obese (BMI ≥36), medically unstable, pregnant, have significant musculoskeletal limitations, or cannot comply with study visits are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants with a history of SCAD and/or FMD will perform acute bouts of aerobic and resistance exercise at varying intensities while wearing cardiopulmonary and hemodynamic monitors. Investigators will record measures such as ventilation, heart rate, blood pressure, and symptom responses during and after each session. Eligible participants must be at least two months post-event, free of chest pain, and able to exercise, while those with BMI ≥36, unstable medical conditions, pregnancy, or musculoskeletal limitations are excluded. All testing is conducted at Mayo Clinic in Jacksonville, Florida under supervised conditions.
Why it matters
Potential benefit: If successful, the results could help define safe exercise levels and guide rehabilitation advice for people with SCAD or FMD.
How similar studies have gone: Exercise testing and cardiac rehabilitation are well-established in other coronary conditions, but targeted exercise data specific to SCAD and FMD are limited, so this is a relatively novel focused approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain. * Able to provide written informed consent Exclusion criteria: * Individuals who are clinically obese (BMI ≥36) and/or who suffer from musculoskeletal or other conditions that would limit exercise participation. * Individuals who are deemed medically unstable * Participants who are unable to comply with study requirements. * Pregnancy
Where it's running
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Mayo Clinic in Florida
Jacksonville, Florida, United States Recruiting
Study contacts
- Principal investigator: Elizabeth H. Dineen, DO — Mayo Clinic
- Study coordinator: Armia R. Habil, MD
- Email: habil.armia@mayo.edu
- Phone: 904-953-0859
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Survey of physical activity and quality of life for people with fibromuscular dysplasia
This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.
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Observational study on spontaneous coronary artery dissection
This study is trying to learn more about spontaneous coronary artery dissection (SCAD) by following 3,000 patients over 10 years to better understand who it affects and how to treat it.
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Understanding Fibromuscular Dysplasia and Related Arteriopathies
This study is trying to collect samples from people with Fibromuscular Dysplasia and related conditions to see what genes might be involved in these diseases.
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Stress contrast echocardiography in adults with prior SCAD
This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.
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Remote exercise program after spontaneous coronary artery dissection
This study tests a remote exercise program to see if it’s doable for women recovering from SCAD events.
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Registry for Spontaneous Coronary Artery Dissection
This study is setting up a large registry to collect information from women who have experienced spontaneous coronary artery dissection to better understand the condition and improve treatment options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.