Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia
Cardiopulmonary, Hemodynamic, And Symptom Responses To Aerobic And Resistance Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia: A Single-center, Single-arm Prospective Clinical Trial.
This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 21 Years to 65 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Trial ID | NCT07526766 on ClinicalTrials.gov |
What this trial studies
Participants with a history of SCAD and/or FMD will perform acute bouts of aerobic and resistance exercise at varying intensities while wearing cardiopulmonary and hemodynamic monitors. Investigators will record measures such as ventilation, heart rate, blood pressure, and symptom responses during and after each session. Eligible participants must be at least two months post-event, free of chest pain, and able to exercise, while those with BMI ≥36, unstable medical conditions, pregnancy, or musculoskeletal limitations are excluded. All testing is conducted at Mayo Clinic in Jacksonville, Florida under supervised conditions.
Who should consider this trial
Good fit: Adults with a history of SCAD and/or FMD who are at least two months post-event, free of chest pain, able to exercise, and able to give informed consent are ideal candidates.
Not a fit: People who are clinically obese (BMI ≥36), medically unstable, pregnant, have significant musculoskeletal limitations, or cannot comply with study visits are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could help define safe exercise levels and guide rehabilitation advice for people with SCAD or FMD.
How similar studies have performed: Exercise testing and cardiac rehabilitation are well-established in other coronary conditions, but targeted exercise data specific to SCAD and FMD are limited, so this is a relatively novel focused approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain. * Able to provide written informed consent Exclusion criteria: * Individuals who are clinically obese (BMI ≥36) and/or who suffer from musculoskeletal or other conditions that would limit exercise participation. * Individuals who are deemed medically unstable * Participants who are unable to comply with study requirements. * Pregnancy
Where this trial is running
Jacksonville, Florida
- Mayo Clinic in Florida — Jacksonville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Elizabeth H. Dineen, DO — Mayo Clinic
- Study coordinator: Armia R. Habil, MD
- Email: habil.armia@mayo.edu
- Phone: 904-953-0859
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.