Sponsor or institution
Clinical trials and research at Istituto Ortopedico Rizzoli
As of November 12, 2026, Find a Trial lists 109 clinical trials run by Istituto Ortopedico Rizzoli that are recruiting, at sites in 2 countries (most in Italy (109), New Zealand (1)). 2 were first registered in the last 30 days. By phase: Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 109Clinical trials
- 2New in 30 days
- 2Countries
Newest trials
All recruiting trials (109)
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Archive of Custom-Made Guides for Orthopedic Surgery
Researchers are testing a digital archive to store and track patient-specific cutting guides used in orthopedic surgeries for people with bone deformities.
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Use of reconstructive microsurgery to treat lymphedema
This study tests whether reconstructive microsurgery, with or without the help of indocyanine green imaging, can help people with lymphedema feel and function better by improving lymphatic drainage.
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ACL reconstruction using the Over-The-Top technique with either metal staples or soft anchors
This study tests whether using a suture-based fixation (soft anchors) during OTT ACL reconstruction works as well as metal staples for graft stability in adults aged 18–50.
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Biomarkers in circulating vesicles for Ewing sarcoma
Researchers will test blood samples from people with Ewing sarcoma to see if circulating biomarkers in extracellular vesicles can help validate new therapies.
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Differences in Outcomes After Allograft vs Autograft in Revision ACL Repair
This study looks at whether using donor tissue (allograft) versus the patient’s own tissue (autograft) in revision ACL surgery leads to different results.
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Hip arthroplasty with a short cementless stem using a direct anterior approach
This study tests whether a short, cementless hip stem implanted through a minimally invasive direct anterior approach works well in adults with hip arthritis.
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Custom 3D-printed total ankle and talus replacement for severe bone loss
This project will try a custom 3D-printed ankle and talus implant to restore function in adults aged 35–75 with severe talar bone loss or compromised ankle bone.
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10-year follow-up after bilateral subtalar arthroereisis with calcaneal stop and endorthesis for correcting pediatric flatfoot
This follow-up will see if children and adolescents who had bilateral subtalar arthroereisis with calcaneal stop and endorthesis keep their flatfoot correction and remain free of pain over 10 years.
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Patterns and links in fibrous dysplasia, McCune‑Albright, and Mazabraud cases
This project collects clinical records, imaging, and tumor tissue from people with fibrous dysplasia, McCune‑Albright, or Mazabraud syndrome to see if specific genetic and radiologic patterns link with symptoms and outcomes.
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Surgical care for people with multiple osteochondromas
This project looks at past surgeries for people with multiple osteochondromas to see what operations were done and what the outcomes were.
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Ankle osteochondral lesion repair with a bone marrow–enriched scaffold and retrograde drilling
This approach will try a bone marrow–enriched scaffold combined with retrograde drilling to repair ankle osteochondral lesions in adults aged 18–55 with subchondral cysts or intact cartilage.
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Total knee replacement with a polyethylene tibial component to see how long it lasts and how patients do
This study tests the 5-year survival and clinical outcomes of a total knee replacement using an all-polyethylene tibial component in people aged 50–85 with knee osteoarthritis or related conditions.
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Tracking early pain and recovery after a limb amputation
This project will look at early post‑operative pain and functional recovery in adults who had a limb amputation to see how pain changes and what factors are linked to better or worse recovery.
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Predicting early mobility after hip or knee replacement using a machine learning model
A machine learning model is being tested to see if it can predict which patients will walk sooner after hip or knee replacement surgery.
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How consistent ILoA scores are and whether staff retraining improves them
This project will test whether physiotherapists give consistent Iowa Level of Assistance (ILoA) scores for patients after hip or knee arthroplasty or femoral fracture and whether retraining staff makes the scores more consistent.
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Outcomes after all-inside meniscal repair alone or with ligament reconstruction
We will see if all-inside meniscal sutures alone or together with ligament reconstruction lead to durable repairs and good knee outcomes in patients aged 12–65 who had meniscal tears.
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Heart structure and function in children and adults with Osteogenesis Imperfecta
This project will follow children and adults with Osteogenesis Imperfecta to see how their heart structure and function change over a five-year period.
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Outcomes and return-to-sport after surgical repair of distal "Stener-like" MCL tears
See how well people ages 12–65 recover and return to sports after surgical re-insertion of a distal "Stener-like" medial collateral ligament tear, whether isolated or with other knee injuries.
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Transarterial microembolization (TAME) for inflamed knee osteoarthritis
This project will try selective arterial embolization (TAME) to reduce chronic pain in adults with moderate inflammatory knee osteoarthritis who have not improved after at least three months of conservative care.
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Autologous microfragmented fat injections with or without hyaluronic acid for both painful knees
This trial will test whether adding hyaluronic acid to injections of your own processed fat helps relieve pain and improve function in people with painful osteoarthritis in both knees.
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Patient-derived 3D tumor models for sarcoma and metastases
This project will try to turn leftover tumor and blood samples from people with sarcoma or with bone or lung metastases into lab-grown 3D tumor models to help test new treatments.
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Functional brain signal changes after ACL reconstruction with targeted neuromotor training
This project will test whether targeted neuromotor training after ACL reconstruction changes brain activity patterns in active adults aged 18–30.
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ACL reconstruction with lateral extra‑articular tenodesis (LET): clinical and biomechanical outcomes
This project will see if adding lateral extra‑articular tenodesis (LET) to ACL reconstruction changes knee stability and recovery in adults 18–50 who receive gracilis and semitendinosus grafts.
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ACL reconstruction with the over-the-top technique plus lateral extra-articular tenodesis in older versus younger patients
This project tests whether ACL reconstruction using the over-the-top technique combined with lateral extra-articular tenodesis gives similar outcomes and complication rates in people over 50 compared with people under 30.
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Multifactorial approaches to prevent foot ulcers in people with diabetic foot
This project will test whether combining biomechanical imaging, clinical exams, metabolic checks, and lab tests can help predict and prevent foot ulcers in adults with type 2 diabetes who either have moderate ulcer risk or healed past ulcers.
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Link between limited ankle dorsiflexion and slower knee motion recovery after total knee replacement
This study will see if people aged 65–85 with limited ankle dorsiflexion have more trouble regaining full knee motion after a primary total knee replacement.
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Arterial embolization for desmoid fibromatosis
This trial tries blocking the tumor blood supply with embolic material (no chemotherapy) in people aged 12 and up who have symptomatic, actively growing desmoid fibromatosis and are not candidates for surgery or cryoablation.
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Analysis of surgical treatments for bone metastases in the proximal femur
This study looks at how well different surgical treatments for bone metastases in the upper thigh bone work for patients who have had fractures.
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Using silver-coated prostheses to reduce hip infection rates
This study tests whether using silver-coated hip implants can help reduce infection rates in patients who are at high risk for infections during and after hip surgery.
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Long-term results of ACL revision surgery using Achilles tendon allograft
This study tests how well revision ACL surgery using an Achilles tendon graft works for patients two years after their surgery and what factors might affect their recovery.
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Comparing two techniques for knee prosthesis surgery
This study is testing whether using a special tensioner device during knee replacement surgery helps patients have better results compared to the standard surgery method.
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Using virtual reality to reduce anxiety in patients before interventional radiology procedures
This study tests if using virtual reality to watch calming videos can help reduce anxiety in patients getting CT-guided biopsies compared to regular preoperative care.
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Telerehabilitation for recovery after rotator cuff surgery
This study tests if online rehabilitation can help people recover just as well as in-person therapy after rotator cuff surgery.
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Assessment of patients with transfemoral amputation using osseointegrated implants
This study is testing if a new type of implant that attaches directly to the bone can help people with transfemoral amputation move better and feel more comfortable than traditional prosthetic sockets.
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Identifying Health Markers to Reduce Complications in Spine Surgery
This study is trying to find out if certain health markers can help predict and reduce complications for people having spine surgery for degenerative conditions.
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Validation of the Italian version of the Knee Society Knee Scoring System
This study is testing a new Italian version of a knee scoring system to see if it accurately measures knee function and pain in patients with knee osteoarthritis.
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Characterization of Multiple Osteochondromas Disorder
This study is testing how hereditary multiple osteochondromas affects people of all ages to improve treatment timing and quality of life, while also trying out new ways to measure joint movement and bone shape.
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Platelet-rich plasma plus hyaluronic acid injections for knee osteoarthritis
We will try a single injection of platelet-rich plasma plus hyaluronic acid, platelet-rich plasma alone, or hyaluronic acid alone to see which works best for adults (40–75) with unilateral knee osteoarthritis who still have pain after conservative treatment.
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Understanding muscle power and control to prevent falls in knee osteoarthritis patients
This study is trying to see if measuring muscle power and control can better predict fall risks in older adults with knee osteoarthritis than just looking at muscle strength alone.
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Comparing computer-assisted and standard techniques in knee replacement surgery
This study is testing whether using computer-assisted techniques during knee replacement surgery leads to better results and lower costs compared to standard surgery methods for patients needing this procedure.
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Using virtual reality to reduce anxiety in children during orthopedic surgery
This study is testing if using virtual reality can help reduce anxiety and pain in children aged 7 to 12 during minor orthopedic surgeries compared to standard care.
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New drug delivery method for treating sarcoma
This study is testing a new way to deliver cancer treatment directly to hard-to-reach sarcoma tumors using tiny particles and light to see if it works better for patients with inoperable tumors.
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Using blood cells to improve osteoporosis diagnosis and monitoring
This study is testing if checking the health of certain blood cells can help doctors better diagnose and monitor osteoporosis in both men and women.
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Custom-made implants for failed hip surgeries
This study is testing whether custom-made hip implants can help adults who need surgery to fix problems from previous hip surgeries due to severe bone damage.
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Evaluating early movement after total ankle replacement
This study tests whether moving around early after ankle replacement surgery helps adults recover better and have improved joint function compared to staying in a cast for three weeks.
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Evaluation of a new implant for lower limb deformity in children
This study looks at how well a new implant works for correcting lower limb deformities in children aged 8 to 15 who have had the procedure, by reviewing their medical records over five years.
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Evaluating fracture risk in patients with bone metastases from cancer
This study looks at medical records of cancer patients with bone metastases to see if it can find ways to predict their risk of fractures.
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Long-term outcomes of meniscal allograft transplantation
This study looks at how well meniscal allograft transplantation has worked for people who had the surgery at least 15 years ago, focusing on their knee health and quality of life now.
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Observing lower limb malformations in infants
This study looks at leg problems in kids under 18 to see how they affect health and family life, while also trying to create better treatment plans using new technology.
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Assessment of meniscal root tears treated with suture to the posterior cruciate ligament
This study tests a new surgical method for fixing meniscal root tears in the knee to see if it helps patients recover better and avoid future problems like arthritis.
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Evaluating hip approaches and navigation in total hip replacement for leg length discrepancies
This study is testing different surgical methods for hip replacement to see which one helps patients with leg length differences feel better and have better results after surgery.
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Understanding knee tissue health and movement
This project will use MRI and gait analysis to see if detailed imaging and movement testing can better characterize knee pain and early cartilage damage in people with mild-to-moderate osteoarthritis.
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Analysis of outcomes after surgery for bone tumors in the proximal femur
This study looks at the results of surgery for bone tumors in the upper thigh bone to see how well it worked for about 150 patients over the past 30 years.
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Using PRP injections to treat knee osteoarthritis in young athletes
This study is testing if PRP injections can help young athletes with knee osteoarthritis feel better and improve their joint health.
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Evaluating outcomes of surgery for biceps tendon injuries
This study looks at how well surgery for biceps tendon injuries works for patients over two years, checking their recovery and any problems that might come up.
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Evaluating long-term outcomes of knee osteotomy for osteoarthritis
This study is testing different knee surgery techniques to see how well they help people with knee osteoarthritis and leg alignment issues over the long term.
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Evaluating outcomes of knee joint surgeries using resorbable screws for osteochondral injuries
This study is testing if using special screws that dissolve can help teenagers and young adults recover better from knee surgeries for cartilage injuries.
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Comparing methods to measure bone density using CT scans
This study tests new ways to measure bone density using CT scans to help people with osteoporosis get better diagnoses and care.
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Evaluating sports activity return after knee surgery in younger patients
This study is testing a special rehab program to help younger patients with knee osteoarthritis safely return to sports after knee surgery.
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Using advanced surgical simulation to correct skeletal defects in children
This study is testing a new way to use 3D technology to help doctors perform safer and more precise surgeries to fix bone problems in children and young adults.
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Evaluating knee prosthesis outcomes using inertial sensors
This study is testing if using special sensors during knee replacement surgery helps people aged 50 to 85 feel better and move easier afterward.
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Comparing bone density changes in knee replacement patients with different implant designs
This study is testing how different knee implant designs affect bone density changes in patients aged 45 and older who are getting knee replacements.
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Comparing standard physiotherapy and eccentric exercises for de Quervain's disease treatment
This study tests whether standard physiotherapy or a special exercise program can help people with de Quervain's disease feel less pain and improve their daily activities.
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Assessing fracture risk in post-menopausal women using BBCT-hip
This study is testing a new method called BBCT-hip to see if it can accurately predict hip fracture risk in post-menopausal women based on their height, weight, and CT scans.
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Using chemoembolization to treat desmoid fibromatosis
This study is testing a new way to treat desmoid fibromatosis by using a targeted chemotherapy method for patients with growing tumors who can’t have surgery.
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Evaluating long-term results of knee realignment surgery
This study is testing if knee realignment surgery can help younger people with arthritis feel better and avoid needing a joint replacement for a longer time.
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Identifying factors that affect survival in Ewing Sarcoma patients
This study looks at how different factors like age and tumor size affect survival rates in people with Ewing sarcoma to help doctors create better treatment plans for patients at higher risk.
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Using telerehabilitation alongside outpatient physiotherapy after hip replacement surgery
This study tests if combining online rehab with regular physiotherapy helps people aged 50 to 80 recover better after hip replacement surgery.
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Comparing imaging techniques for predicting desmoid tumor progression after cryoablation
This study is testing if a new imaging method can better predict how desmoid tumors change after cryoablation treatment compared to standard methods.
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Evaluation of a Carbon Fiber Device for Spinal Surgery
This study is testing a new carbon fiber device for spinal surgery to see if it works better than traditional titanium screws for patients with degenerative spinal diseases.
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Comparing customized and standard ankle replacements
This study is testing whether customized ankle replacements made just for you work better than standard ones for people with ankle osteoarthritis.
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Treatment for low-flow venous malformations using electrosclerotherapy
This study is testing if a new treatment using electrosclerotherapy with Bleomycin can safely help people with low-flow venous malformations feel better.
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Using arterial embolization to treat bone metastases
This study is testing whether a minimally invasive treatment called arterial embolization can help reduce pain and improve outcomes for patients with bone metastases.
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Comparing custom and standard knee replacements
This study is testing if custom 3D-printed knee implants can help people with knee osteoarthritis have better surgery results and feel more satisfied compared to standard knee replacements.
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Observing endothelial damage during major spine surgery
This study is trying to see if major spine surgery causes damage to blood vessel lining by checking blood samples from patients before and after their surgery.
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Validation of the Italian Forgotten Joint Score for ankle replacement patients
This study is testing a new Italian questionnaire to see if it accurately measures how well patients feel after having ankle replacement surgery.
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Surgical treatment for flexible flatfoot in children
This study is testing a surgery to see if it can help children aged 8 to 14 with flexible flatfoot by improving the alignment of their foot bones as they grow.
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Evaluating plantar pressures after foot and ankle surgeries
This study tests how different foot and ankle surgeries affect pressure on the bottom of the foot to help understand recovery better.
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Comparing bone marrow and fat tissue injections for knee osteoarthritis treatment
This study is testing whether injections of bone marrow or fat tissue can help people with knee osteoarthritis feel better and improve their condition over a year.
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Comparing different types of PRP injections for treating tennis elbow
This study is testing whether two different types of PRP injections can help people with tennis elbow who haven't found relief from other treatments.
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Observing local relapse in patients with high-grade osteosarcoma
This study looks at patients with high-grade osteosarcoma who had a local relapse after treatment to see what patterns and outcomes are common.
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Percutaneous correction of bunions
This study tests a new, less invasive surgery for bunions to see if it works better and is safer than traditional surgery for people who need treatment.
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Evaluating joint stability in patients with collagen diseases and hypermobility
This study is testing how well people with collagen diseases and joint hypermobility can keep their balance and stability during activities to see if postural corrections can help them.
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Comparing minimally invasive surgery to standard surgery for adolescent idiopathic scoliosis
This study is testing whether a new, less invasive surgery for scoliosis can work just as well as the traditional surgery for teens and young adults.
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Using acellular dermal matrix to enhance repair of massive rotator cuff tears
This study is testing if using a special skin-based material during surgery can help people with large rotator cuff tears heal better and recover faster.
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Knee osteotomy with meniscus transplantation for knee osteoarthritis
This study is testing if adding a meniscus transplant to knee surgery helps people with knee osteoarthritis feel better and move easier compared to just the knee surgery alone.
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Personalized home exercise program for patients with bone tumors after surgery
This study tests whether a personalized home exercise program helps patients with bone tumors recover better after surgery and chemotherapy.
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Comparing two types of PRP injections for hip osteoarthritis treatment
This study is testing whether two different types of PRP injections can help people with hip osteoarthritis feel better over a year.
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Global collaboration on undifferentiated round cell sarcoma
This study is trying to learn more about undifferentiated round cell sarcomas by looking at past and current cases to better understand this rare type of cancer.
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Using a special scaffold to treat knee osteochondritis dissecans
This study is testing if a special scaffold treatment can help young people with knee osteochondritis dissecans heal better after surgery.
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Collecting data on patients with rare bone diseases
This study is collecting information from people with rare bone diseases to better understand their conditions and improve diagnosis and care.
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Using cryotherapy to treat desmoid tumors
This study is testing whether cryotherapy can be a safe and effective treatment for adults with desmoid tumors, offering a new option for those who may not want chemotherapy.
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Comparing collagen injection to placebo for knee osteoarthritis
This study is testing if a single injection of collagen can help people with knee osteoarthritis feel better compared to a placebo shot.
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Registry for Li Fraumeni and Li Fraumeni-Like Syndromes
This study is creating a registry to gather information from people with Li-Fraumeni and Li-Fraumeni-Like Syndromes to help understand these conditions better and improve diagnosis and research.
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Comparing PRP and HA injections for knee osteoarthritis
This study is testing whether injections of platelet-rich plasma or hyaluronic acid can help people with knee osteoarthritis feel better over two years.
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Comparing PRP injections to placebo for knee osteoarthritis in older adults
This study is testing if a single injection of platelet-rich plasma can help older adults with knee osteoarthritis feel better compared to a placebo.
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Evaluating diagnostic markers for joint infections in hip and knee surgeries
This study is testing if certain blood and joint fluid markers can help doctors quickly and accurately diagnose joint infections in patients having hip or knee revision surgeries.
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Using Metformin to Prevent Relapse in Bone Sarcoma Patients
This study is testing if Metformin can help prevent relapse in patients with osteosarcoma and Ewing sarcoma who are at high risk of their cancer coming back.
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Comparing digital and paper methods for assessing knee prosthetic outcomes
This study is testing whether using digital questionnaires on smartphones or traditional paper forms is better for understanding how patients feel after knee replacement surgery.
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Comparing digital and paper methods for assessing hip surgery outcomes
This study tests whether using digital questionnaires on smartphones is better than paper forms for collecting feedback from patients after hip surgery.
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Assessing Osteosarcopenia in Patients with Hip Fractures
This study is testing if certain tests can help identify muscle and bone issues in patients with hip fractures to improve their recovery after surgery.
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Registry for Ollier Disease and Maffucci Syndrome
This study is creating a registry to gather information from people with Ollier Disease and Maffucci Syndrome to help understand these rare conditions better and improve diagnosis and research.
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Registry for Multiple Osteochondromas
This study is creating a registry to gather information from people with Multiple Osteochondromas to help improve diagnosis and understanding of the condition.
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Registry for Ehlers-Danlos Syndrome
This study is creating a registry to gather information from people with Ehlers-Danlos Syndrome to help researchers learn more about the condition and improve care for patients.
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Registry for Osteogenesis Imperfecta
This study is creating a registry to gather information from people with Osteogenesis Imperfecta to better understand the condition and improve how it's managed and treated.
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Comparing fast track and standard care for total knee replacement
This study is testing if a quicker recovery plan for knee replacement surgery helps patients feel better and recover faster compared to the usual care.
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Monitoring outcomes after ACL reconstruction surgery
This study is tracking how well people recover after ACL surgery over five years to see what helps them heal better.
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Evaluating knee laxity during ACL and meniscus surgeries
This study tests how loose the knee is in people having surgery for ACL injuries or meniscus problems to see how well the surgeries work.
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Collecting data on patients with bone metastases treated for fractures
This study is trying to see how different surgical treatments for bone fractures in cancer patients affect their recovery and survival.
Quick answers
How many clinical trials run by Istituto Ortopedico Rizzoli are recruiting right now?
109, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in Italy (109 trials), New Zealand (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.