Functional brain signal changes after ACL reconstruction with targeted neuromotor training

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who have undergone anterior cruciate ligament reconstruction will complete a dedicated neuromotor training program and undergo functional MRI scanning. The study measures volumetric activation in cortical motor and sensorimotor regions during lower-limb tasks before and after the training intervention. Eligible participants are physically active young adults (Tegner >6) without neurological disorders or prior lower-limb surgeries and who can safely undergo MRI. The goal is to link targeted rehabilitation exercises with central nervous system changes that may support improved neuromuscular control.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have undergone anterior cruciate ligament reconstruction surgery at any healthcare facility
* Able to understand and consent, adults, who have provided informed consent to participate in the study
* Male or female
* Age between 18 and 30 years at the time of signing the informed consent
* Tegner activity level \> 6

Exclusion Criteria:

* History and/or evidence of any neurological disorder or functional impairment;
* Evidence of previous surgeries on the lower limb;
* Inability to provide informed consent;
* Inability to perform the tasks required by the procedure;
* Pregnant or breastfeeding women;
* Oncology patients;
* Contraindications to undergoing MRI examinations.

Where it's running

• IRCCS Istituto Ortopedico Rizzoli
  Bologna, Bologna, Italy Recruiting

Study contacts

• Study coordinator: Stefano Zaffagnini
• Email: stefano.zaffagnini@ior.it
• Phone: 051636

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.