Clinical trial Recruiting at 1 site Observational Ages 2 and up

Identifying factors that affect survival in Ewing Sarcoma patients

Official title: Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

Run by Istituto Ortopedico Rizzoli · NCT06243588 · Data updated 2026-11-12

This study looks at how different factors like age and tumor size affect survival rates in people with Ewing sarcoma to help doctors create better treatment plans for patients at higher risk.

Quick facts

Study typeObservational
Ages2 Years and up
SexAll
Enrollment400 (estimated)
SponsorIstituto Ortopedico Rizzoli
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Bologna, BO)
StatusRecruiting
StartedJanuary 25, 2024
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedMarch 5, 2025
Trial IDNCT06243588 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are male and female patients aged 2 years and older who have been diagnosed with Ewing sarcoma and have available clinical and imaging data.

Probably not a fit

Patients who do not meet the inclusion criteria, such as those without a diagnosis of Ewing sarcoma or lacking clinical data, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the correlation between various factors such as age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation, and biomarkers with overall survival and relapse-free survival in patients diagnosed with Ewing sarcoma. By reviewing clinical records of patients treated at the Rizzoli Orthopaedic Institute over a 30-year period, the study seeks to identify reliable prognostic factors that could help in stratifying patients based on their risk levels. This information may lead to tailored treatment approaches for high-risk patients.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for patients with Ewing sarcoma by identifying those at higher risk for poor outcomes.

How similar studies have gone: While the approach of identifying prognostic factors in Ewing sarcoma has been explored in other studies, this specific observational study may provide novel insights based on a comprehensive review of long-term clinical data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021
* Age ≥ 2 years
* Diagnosis of Ewing Sarcoma
* Patients with available clinical and imaging data

Exclusion Criteria:

* At least one inclusion criterion not met

Where it's running

  • IRCCS Itituto Ortopedico Rizzoli
    Bologna, Bo, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.