Using PRP injections to treat knee osteoarthritis in young athletes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of homologous platelet-rich plasma (PRP) injections for treating knee osteoarthritis in young athletic patients aged 18-40. The trial involves a three-phase approach, including patient enrollment, the infiltrative procedure, and follow-up assessments at 1, 3, 6, and 12 months post-treatment. Patients will undergo clinical evaluations and complete questionnaires to assess pain levels and joint function, while any adverse events will also be monitored. The goal is to determine the impact of PRP on symptoms and joint health in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients, both sexes, with symptomatic knee osteoarthritis with:
* Age: 18-40 years;
* Unilateral involvement;
* Signs and symptoms of knee osteoarthritis;
* Radiographic or MRI signs of degenerative pathology of knee cartilage (Kellgren-Lawrence grade 1-3);
* Ability and consent of patients to actively participate in clinical follow-up;
* Signature of informed consent;
* Pain ≥ 4 on VAS s

Exclusion Criteria:

* Patients unable to express consent;
* Patients undergoing intra-articular infiltration of other substance in the previous 6 months;
* Patients undergoing knee surgery in the previous 12 months;
* Patients with malignant neoplasms;
* Patients with rheumatic diseases;
* Patients with uncontrolled metabolic diseases;
* Patients with hematological diseases (coagulopathies);
* Patients abusing alcoholic beverages, drugs or medications;
* Knee trauma treated in the previous 6 months.
* Other conditions that may interfere with the evaluation of OA treatment.

Where it's running

• IRCCS - Istituto ortopedico Rizzoli
  Bologna, Italy Recruiting

Study contacts

• Study coordinator: Mirco Lo Presti, MD
• Email: mirco.lopresti@ior.it
• Phone: 0516366

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.