Using cryotherapy to treat desmoid tumors
Official title: Cryotherapy in the Treatment of Desmoid Tumors
Run by Istituto Ortopedico Rizzoli · NCT05091255 · Data updated 2026-11-12
This study is testing whether cryotherapy can be a safe and effective treatment for adults with desmoid tumors, offering a new option for those who may not want chemotherapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 94 (estimated) |
| Sponsor | Istituto Ortopedico Rizzoli Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Bologna, BO) |
| Status | Recruiting |
| Started | May 20, 2021 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | August 1, 2025 |
| Trial ID | NCT05091255 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old with a histologic diagnosis of abdominal or extra-abdominal desmoid tumors.
✕Probably not a fit
Patients with contraindications to cryotherapy or those with retroperitoneal desmoid tumors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of cryotherapy as a minimally invasive treatment for desmoid tumors, which are benign neoplasms known for their unpredictable behavior and high recurrence rates after surgical intervention. The approach aims to provide an alternative to chemotherapy, particularly for younger patients, by utilizing cryotherapy to target the tumors directly. Participants will include adults diagnosed with abdominal and extra-abdominal desmoid tumors, while those with contraindications or specific tumor locations will be excluded. The study seeks to evaluate the effectiveness and safety of this treatment method.
Why it matters
Potential benefit: If successful, this approach could provide a safer, less invasive treatment option for patients with desmoid tumors, reducing the need for chemotherapy.
How similar studies have gone: While the use of cryotherapy for desmoid tumors is a novel approach, similar minimally invasive techniques have shown promise in treating other tumor types.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * histologic diagnosis of desmoid tumors * age \> 18 years * abdominal and extra-abdominal desmoid tumors Exclusion Criteria: * contraindication to the procedure by the interventional radiologist in terms of tumor proximity to neurologic/vascular structures * retroperitoneal desmoid tumors * age \< 18 years
Where it's running
-
IRCCS Itituto Ortopedico Rizzoli
Bologna, Bo, Italy Recruiting
Study contacts
- Study coordinator: Costantino Errani, MD
- Email: costantino.errani@ior.it
- Phone: 051-6366
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using chemoembolization to treat desmoid fibromatosis
This study is testing a new way to treat desmoid fibromatosis by using a targeted chemotherapy method for patients with growing tumors who can’t have surgery.
-
Comparing imaging techniques for predicting desmoid tumor progression after cryoablation
This study is testing if a new imaging method can better predict how desmoid tumors change after cryoablation treatment compared to standard methods.
-
FOG-001 treatment for advanced or metastatic solid tumors
This study is testing a new drug called FOG-001 to see if it can help people with advanced solid tumors, especially those with certain genetic changes, when traditional treatments aren't working.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.