Using blood cells to improve osteoporosis diagnosis and monitoring

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the diagnosis and monitoring of osteoporosis by evaluating the vitality of peripheral blood mononuclear cells (PBMCs) in relation to bone metabolism alterations. It focuses on understanding how PBMCs behave in different stages of osteoporosis, particularly considering gender differences. The study will correlate the in vitro viability of PBMCs with Dual-X-ray Absorptiometry (DXA) results to better stratify patients at risk of fractures. By developing a new diagnostic tool based on PBMCs, the study seeks to address the inadequacies of current osteoporosis assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy patients (at risk and undergoing periodic follow-up and/or attending outpatient visits for preventive screening)
* Osteopenic patients with an available DXA
* Osteoporotic patients (fractured and non-fractured) with an available DXA or, for fractured patients, a DXA prescribed as part of clinical practice
* Aged ≥ 40 years of both sexes
* Body Mass Index (BMI) between 18.5 and 29.9

Exclusion Criteria:

* Hematopoietic system disorders (hemolytic, aplastic, and neoplastic anemias)
* Coagulation disorders (hereditary or secondary to other disorders)
* Infections (including HIV-HBV-HCV positivity)
* Neoplastic diseases (primary and/or secondary tumors)
* Pregnancy or breastfeeding
* Alcohol consumption (\>20 g of alcohol per day currently or in the past)
* Smoking (\>10 cigarettes per day, currently or in the past)
* Diabetes
* Treatment with therapeutic agents that may interfere with hematopoiesis (corticosteroids, immunosuppressive agents, cytotoxic drugs)

Where it's running

• Istituto Ortopedico Rizzoli
  Bologna, Italy Recruiting
• Azienda Ospedaliero Universitaria Policlinico G.Rodolico - San Marco
  Catania, Italy Recruiting

Study contacts

• Study coordinator: Alberto Corrado Di Martino
• Email: albertocorrado.dimartino@ior.it
• Phone: 0516366

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Functional Muscle-Bone Incongruity Index: A look at muscle strength and bone health in adults

  This observational study tests a composite FKUI score using handgrip strength and hip/spine bone density to see if it better reflects musculoskeletal health than each measure alone in adults undergoing routine DXA.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07677033

• Using REMS ultrasound to check bone density in children and teens with conditions that lower bone strength

  This project will test whether REMS, a radiation-free ultrasound method, can measure bone mineral density in children and adolescents aged 5–18 who have conditions that weaken their bones.

  Recruiting Meyer Children's Hospital IRCCS · Florence, Tuscany · NCT07412782

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Vitamin K2 supplementation for patients with low bone density and a specific gene variant

  This study is testing if taking vitamin K2 can help improve bone density in adults aged 40-75 with low bone density who have a specific gene variant.

  Recruiting S.lab (Soloways) · Novosibirsk · NCT06867952

• Role of LH and hCG in adults being evaluated for endocrine disorders

  This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.

  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• Can a blood marker called lumican reveal hidden fragility in postmenopausal osteoporosis

  This study tests whether serum lumican levels can help identify hidden fragility risk in postmenopausal women beyond what bone density shows.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07677072

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.