Using chemoembolization to treat desmoid fibromatosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on the treatment of desmoid fibromatosis, a rare and locally aggressive tumor, using arterial chemoembolization with Doxorubicin. The approach aims to exploit the hypervascular nature of desmoid tissue to deliver chemotherapy directly to the tumor while minimizing systemic toxicity. Patients eligible for this treatment are those with symptomatic, actively growing tumors who are not candidates for surgery or cryoablation. The study will gather data on the efficacy and safety of this method based on previous retrospective and prospective studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* FIbromatosis demsoid symptomatic and in active phase (documented growth at last follow-ups)
* Patients who are not candidates for surgery or cryoablation

Exclusion Criteria:

* Patients with life expectancy \<3 months or severely impaired status functional status (ASA 4)
* Patients with fibromatosis not in active phase, documented clinically and by investigations imaging (MRI, CT)
* Patients with coagulation deficiency or plateletopenic disease
* Patients with documented active infection

Where it's running

• Istituto Ortopedico Rizzoli
  Bologna, Emilia-Romagna, Italy Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  This study is testing if a new imaging method can better predict how desmoid tumors change after cryoablation treatment compared to standard methods.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06224283

• FOG-001 treatment for advanced or metastatic solid tumors

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• Using cryotherapy to treat desmoid tumors

  This study is testing whether cryotherapy can be a safe and effective treatment for adults with desmoid tumors, offering a new option for those who may not want chemotherapy.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, BO · NCT05091255

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.