Evaluating joint stability in patients with collagen diseases and hypermobility

Evaluation of Functional Instability Using the "Delos Proprioceptive System" in Patients Suffering From Collagen Disease and Joint Hypermobility

Observational Istituto Ortopedico Rizzoli · NCT05871216

This study is testing how well people with collagen diseases and joint hypermobility can keep their balance and stability during activities to see if postural corrections can help them.

Quick facts

Study typeObservational
Enrollment30 (estimated)
Ages18 Years to 60 Years
SexAll
SponsorIstituto Ortopedico Rizzoli Academic / other
Locations1 site (Bologna)
Trial IDNCT05871216 on ClinicalTrials.gov

What this trial studies

This observational study focuses on patients suffering from collagen diseases and joint hypermobility, specifically assessing their joint stability and balance. It utilizes clinical tests and the Delos Proprioceptive System to evaluate the effectiveness of postural corrections during dynamic activities. The study aims to identify deficiencies in balance that may affect daily and sporting activities, particularly in individuals diagnosed with Joint Hypermobility Syndrome. Diagnosis is based on the Beighton score and the presence of arthralgia in multiple joints.

Who should consider this trial

Good fit: Ideal candidates include individuals with moderate to severe joint hyperlaxity as indicated by the Beighton-Horan Joint Mobility Index.

Not a fit: Patients with obesity, significant comorbidities, or those without joint hyperlaxity will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for patients with joint hypermobility and related conditions.

How similar studies have performed: While there is ongoing research in this area, the specific approach of using the Delos Proprioceptive System for balance evaluation in this patient population is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with moderate (Beighton-Horan Joint Mobility Index score from 3 to 4) or severe (Beighton-Horan Joint Mobility Index score from 5 to 9) joints hyperlaxity at the clinical evaluation

Exclusion Criteria:

* Obesity (BMI \> 25) and weight \> 90 kg
* Practice of competitive sport
* Orthopedic (complex surgery of the spine and lower limbs), neurological (spasticity, stroke), and oncological comorbidities
* Orthostatic / walking inability
* Absence of joints hyperlaxity at the clinical evaluation (Beighton-Horan Joint Mobility Index score from 0 to 2)

Where this trial is running

Bologna

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Hypermobility SyndromeDanlos Disease, EhlersCollagen DiseasesJoint HypermobilityLaxity of Ligament
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.