Comparing methods to measure bone density using CT scans
Comparative Evaluation of Phantomless Calibration Methods to Quantify Bone Mineral Density for Opportunistic Analysis of CT Scans
This study tests new ways to measure bone density using CT scans to help people with osteoporosis get better diagnoses and care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Istituto Ortopedico Rizzoli Academic / other |
| Drugs / interventions | radiation |
| Locations | 2 sites (Bologna, Bo and 1 other locations) |
| Trial ID | NCT06454617 on ClinicalTrials.gov |
What this trial studies
This study evaluates different calibration methods for quantifying bone mineral density (BMD) using CT scans, aiming to improve the diagnosis and management of osteoporosis. It focuses on patients who are undergoing CT scans of the lumbosacral spine or abdomen, assessing the effectiveness of phantomless calibration techniques. By analyzing the data collected from these scans, the study seeks to enhance the detection of fracture risk associated with osteoporosis. The goal is to provide a more accessible and accurate means of diagnosing this prevalent condition.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who require a CT scan of the lumbosacral spine or abdomen for any clinical indication.
Not a fit: Patients with severe degenerative conditions of the spine, significant scoliosis, or those with contraindications to CT scans may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and management of osteoporosis, potentially reducing the risk of fractures in patients.
How similar studies have performed: While the approach of using CT scans for opportunistic analysis of bone density is gaining interest, this specific calibration method is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Both sexes. * All ethnicities. * Age equal or above 18 years. * Any clinical indication (no specific pathology is required) for a CT scan of the lumbosacral spine or abdomen in which the entire lumbar spine (L1 to L5), paravertebral muscles, abdominal aorta, and subcutaneous adipose tissue are visible. * Ability to give informed consent. Exclusion Criteria: * General contraindications to CT examination, including pregnancy or body weight/size exceeding scanner limits. * Severe degenerative manifestations of the lumbosacral spine. * Severe scoliosis of the lumbosacral spine. * Surgical hardware that prevents adequate CT scanning. * Oncologic pathology in progress or in recent history. * Any other situation deemed incompatible with the study by the designated physician or investigator.
Where this trial is running
Bologna, Bo and 1 other locations
- The Rizzoli Orthopaedic Institute — Bologna, Bo, Italy (Recruiting)
- Auckland Hospital - Greenlane Clinical Centre - National Women's Hospital — Auckland, New Zealand (Not_yet_recruiting)
Study contacts
- Study coordinator: Alberto Bazzocchi, MD
- Email: alberto.bazzocchi@ior.it
- Phone: 051636
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.