Global collaboration on undifferentiated round cell sarcoma
Official title: Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project
Run by Istituto Ortopedico Rizzoli · NCT05357768 · Data updated 2026-11-12
This study is trying to learn more about undifferentiated round cell sarcomas by looking at past and current cases to better understand this rare type of cancer.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 260 (estimated) |
| Sponsor | Istituto Ortopedico Rizzoli Academic / other |
| Locations | 1 site (Bologna, BO) |
| Status | Recruiting |
| Started | June 11, 2019 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2028 |
| Registry record updated | May 30, 2025 |
| Trial ID | NCT05357768 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with undifferentiated round cell sarcomas who have available clinical and outcome information, as well as tumor tissue samples.
✕Probably not a fit
Patients with diagnoses other than undifferentiated round cell sarcomas or those lacking clinical and outcome information will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational study aims to analyze cases of undifferentiated round cell sarcomas by reviewing clinical and histological data from both retrospective and prospective sources. It will include cases diagnosed from January 1983 onward, as well as new cases at participating sites. The study will focus on collecting and analyzing formalin-fixed paraffin-embedded tissue and/or frozen tumor samples to better understand this rare cancer type.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and treatment options for patients with undifferentiated round cell sarcoma.
How similar studies have gone: While there may be limited data on similar studies, this approach of analyzing historical and new cases in collaboration across multiple centers is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included. * Clinical and outcome information available. * Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available. Exclusion Criteria: * Diagnosis different from undifferentiated round cell sarcomas * Patient with no clinical or outcome information available
Where it's running
-
IRCCs Istituto Ortopedico Rizzoli
Bologna, Bo, Italy Recruiting
Study contacts
- Study coordinator: Emanuela Palmerini, MD
- Email: emanuela.palmerini@ior.it
- Phone: 051.63.66
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.