Understanding knee tissue health and movement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol combines advanced, tissue-specific MRI sequences with gait analysis to characterize the pathophysiological and functional state of the knee joint. Eligible participants have knee pain or reduced function with Kellgren-Lawrence grade ≤2 and arthroscopic evidence of cartilage lesions. The protocol excludes people with prior partial or total knee replacement and those with contraindications to MRI or electrical stimulation. All procedures are performed in person at a single center using imaging and biomechanical measures to link tissue changes with functional impairment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Knee pain and/or loss of functionality
* Kellgren-Lawrence grade less than or equal to 2
* Arthroscopic evidence of cartilage tissue lesions
* Evidence of cartilage and/or meniscal tissue degeneration and/or subchondral bone marrow lesions

Exclusion Criteria:

* History/evidence of previous partial or total knee prosthesis interventions
* Inability to provide informed consent
* Conditions or physical disorders incompatible with the use of MRI and electrical stimulation (implanted active and passive biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)

Where it's running

• IRCCS Istituto Ortopedico Rizzoli
  Bologna, Italy Recruiting

Study contacts

• Study coordinator: stefano zaffagnini
• Email: stefano.zaffagnini@unibo.it
• Phone: +390516366075

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.