Assessing Osteosarcopenia in Patients with Hip Fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates clinical and laboratory parameters to identify osteosarcopenia in patients undergoing hip replacement due to fragility fractures. It compares these patients to those with hip replacements for osteoarthritis, where muscle function and bone quality are less affected. The goal is to find reliable biomarkers that can be easily applied in hospitalized patients to tailor postoperative interventions and improve recovery outcomes. The study will utilize assessments such as the SARC-F questionnaire and serum levels of myostatin and IGF-1.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who came to observation with femoral neck fracture of possible osteoporotic nature (no or minimal trauma) to be treated with endoprosthesis or hip arthroplasty.
* Competent patients who have signed consent to participate in the study (see Informed Consent section of this protocol).

Exclusion Criteria:

* Previous osteoporotic fractures
* Previous prosthetic surgery for orthopedic diseases
* Pre-existing clinical conditions that led to permanent immobility
* Neoplastic diseases
* Autoimmune diseases
* Severe myopathies
* Chronic viral infections (HBV, HCV, HIV);
* Chronic treatment with anti-osteoporotic drugs, immunosuppressive drugs, and insulin
* Paget's disease

Where it's running

• Istituto Ortopedico Rizzoli
  Bologna, Italy Recruiting

Study contacts

• Principal investigator: Nicola Baldini, M.D. — University of Bologna, Istituto Ortopedico Rizzoli
• Study coordinator: Gemma Di Pompo, M.Sc.
• Email: gemma.dipompo@ior.it
• Phone: +39 0516366748

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.