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Clinical trials and research at Assistance Publique - Hôpitaux de Paris

• 536Clinical trials
• 8Countries

Newest trials

All recruiting trials (newest 150 of 536)

• Diffusion MRI to map nerve lesions in obstetric brachial plexus palsy

  This study tests diffusion MRI and tractography to better understand nerve injuries in people with obstetric brachial plexus palsy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07767708

• Long-term心理 and cognitive check after stem cell transplant for immune deficiencies

  This study tests the long-term neurocognitive and psychological functioning of 6–8 year-old children who had an allogeneic stem cell transplant for a primary immune deficiency, at least two years after the transplant.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07766304

• Benchmarking AI language models against tumor boards for oncology treatment decisions

  This project tests whether frontier AI language models can match the treatment recommendations of multidisciplinary tumor boards for common cancers using standardized synthetic cases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt and 4 other locations · NCT07739121

• Gut microbes and autoinflammatory diseases: how they may be linked

  This study tests whether gut bacteria and their byproducts relate to digestive and inflammatory symptoms in people with autoinflammatory diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07718555

• How Eye Dominance Affects Fusion in Healthy Adults

  This study tests whether fusional vergence measurements differ when tested on the dominant eye versus the non-dominant eye in healthy adults.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07697131

• Breast cancer risk check for night shift workers with a personalized prevention plan

  This study tests whether a personalized prevention plan helps female night shift workers at higher risk for breast cancer stick to healthier habits and screening over 5 years.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07630935

• Compare cardiac index by right ventricular waveform vs. thermodilution in septic shock patients

  This study tests whether the continuous cardiac index estimated from the right ventricular pressure waveform matches the thermodilution measurement in adults with septic shock who already have a Swan-Ganz catheter in place.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Angers and 1 other locations · NCT07628023

• Student Precarity and Psychiatry: How Financial Struggles Relate to Depression and Loneliness

  This observational study looks at whether financial hardship and social isolation are linked to depression, suicidal thoughts, and loneliness among French university students.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, IDF · NCT07618208

• Repeated ultrasound-assisted blood-brain barrier opening in ALS

  This trial tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and may help people with ALS.

  Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07571486

• 4D-Flow MRI to see portal hypertension and TIPS outcomes in cirrhosis

  This study tests a noninvasive 4D-Flow MRI method to see if it can safely and reliably reflect portal hypertension and predict outcomes for people with cirrhosis, including those needing a TIPS procedure.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07554183

• Self-awareness and social understanding in behavioral frontotemporal dementia and Alzheimer's disease

  This project sees if people with bvFTD or Alzheimer's can accurately judge their own emotion-recognition and social-cognitive performance using a computerized face-emotion task with confidence ratings.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07531732

• Low-dose CT Lung Cancer Screening in France for 50–74-Year-Old Smokers

  This study tests whether offering low-dose chest CT screening to adults aged 50–74 who smoke or recently quit is feasible and safe at a population level.

  Recruiting Assistance Publique - Hôpitaux de Paris · Lyon, France and 1 other locations · NCT07513818

• Prediction-model guided drug choice to prevent impulse control disorders in Parkinson's

  This trial tests whether an algorithm-guided approach to prescribing Parkinson’s disease medicines can reduce impulse control problems compared with usual care in adults with Parkinson’s.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07505394

• New six-month regimen for MDR-TB in France using BPaLM or BPaLC/BPaLM+Clofazimine

  This trial tests whether a six-month, bedaquiline-containing treatment strategy for rifampicin-resistant TB works as well as the long traditional regimens used in France by comparing outcomes to a historical cohort.

  Recruiting at 4 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Amiens and 4 other locations · NCT07486024

• Plasma cell-free DNA in children with ALL to help monitor disease

  This study tests whether measuring tumor DNA in blood can help monitor acute lymphoblastic leukemia in kids without needing frequent bone-marrow tests.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07483476

• Capsule camera screening of the small intestine for people with Lynch syndrome

  This project looks back at past small-bowel capsule endoscopy exams to see if they detect precancerous lesions or early cancer in people with Lynch syndrome.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07472686

• Supporting the move from pediatric to adult rheumatology care for young people with childhood inflammatory rheumatic diseases.

  This project will see if a structured transition program (early preparation, a therapeutic education workshop, and a joint pediatric–adult visit) helps young people with childhood inflammatory rheumatic diseases manage their care after moving to adult rheumatology.

  Recruiting Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre · NCT07469787

• Non-Invasive Prenatal Exclusion Diagnosis for Severe Monogenic Disorders

  This study checks if a blood test using fetal DNA from mom can help identify or exclude certain severe monogenic disorders without invasive procedures, for couples at risk.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07469657

• FOLFIRINOX Induction for Rectal Cancer with Synchronous Liver Mets

  This study tests whether giving at least two cycles of FOLFIRINOX before surgery helps treat both rectal cancer and liver metastases in adults with resectable disease.

  Recruiting Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre · NCT07467434

• French translation and adaptation of the COMFORTneo pain tool for newborns

  This project tests a French translation of the COMFORTneo pain assessment tool for newborns to help doctors and nurses in Paris identify pain in term and preterm babies.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07463170

• Light therapy response in unipolar and bipolar major depressive episodes

  This study tests whether light therapy helps adults with a major depressive episode respond to treatment, including those with unipolar or bipolar depression.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07462637

• Self-management app to help people with inflammatory arthritis stay safe

  A smartphone app from the French Rheumatology Society is being tested to help adults with rheumatoid arthritis or spondyloarthritis manage their treatments and safety while starting a new DMARD.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07460739

• Autoimmune neurological diseases and neurotoxicity after immunotherapy: uncovering immune attack mechanisms

  This study tests why some cancer patients who receive immune checkpoint inhibitors develop neurological symptoms by examining their blood and spinal fluid for immune clues.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre and 3 other locations · NCT07456358

• Fibroscan use to help diagnose acute heart failure in the emergency department

  This study tests whether a FibroScan device can quickly help doctors identify acute heart failure in adults who come to the ED with sudden shortness of breath.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07449377

• Language development with cochlear implants and speech-language therapy in young children

  This study looks at how speech-language therapy, either auditory-phonological or auditory-verbal, helps young children with severe to profound prelingual hearing loss who have cochlear implants.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07447427

• Blood clotting and portal vein changes during TIPS placement in cirrhosis

  This project will see how blood clotting in the body and in the portal vein changes in adults with cirrhosis who are having a TIPS placed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif · NCT07439939

• Social cognition testing for 8–16-year-olds with autism, ADHD, or atypical development

  This project will test a multidimensional social-cognition battery in French-speaking 8–16-year-olds with autism, ADHD, or atypical neurodevelopment to see if it better identifies social processing differences.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07439276

• Gene therapy using corrected β-globin and a silencing RNA in your own CD34+ stem cells for severe sickle cell disease

  This trial will try a one-time gene therapy using a patient’s own modified CD34+ stem cells to reduce painful vaso-occlusive crises and long-term organ damage in people aged 12–35 with severe sickle cell disease.

  Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07432867

• Coronary Plaque Progression in HeFH: DESTINY-FH

  This study tests how heart arteries change over 5 years in people with heterozygous familial hypercholesterolemia using coronary CT angiography.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 2 other locations · NCT07427472

• See if eSRT helps set comfort levels in kids with cochlear implants

  This study tests whether measuring electrically evoked stapedius reflex threshold (eSRT) can help customize cochlear implant settings for children up to age 7.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07417956

• French national cohort of people with PRSS1 mutations

  This project will follow people with PRSS1 gene mutations to see if they develop pancreatic adenocarcinoma and to describe how hereditary pancreatitis progresses over time.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clichy-sous-Bois · NCT07413029

• Identifying insulin-resistant PCOS with LMNA-related lipodystrophy in young women

  We’re testing whether women with a genetic insulin resistance and lipodystrophy differ from women with PCOS by age and BMI matching.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07412028

• A hospital biobank of leftover clinical samples to support rapid diagnostic tests for emerging infectious threats.

  This project will collect leftover samples from hospitalized adults to help test rapid diagnostic tools for emerging infectious diseases and CBRN threats.

  Recruiting at 10 sites Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre and 9 other locations · NCT07411729

• Testing the French PHQ-4 and PC-PTSD-5 short mental health screens

  This project will test whether the French PHQ-4 and PC‑PTSD‑5 questionnaires work well to quickly screen for anxiety/depression and PTSD in French-speaking adults seen in hospital or outpatient care.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bobigny · NCT07396623

• Immune mechanisms in acute respiratory distress syndrome in ventilated ICU patients.

  This project will test whether patterns of inflammatory markers in blood match gene activity of lung immune cells in adults with ARDS who are on mechanical ventilation.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07395076

• Real-world use of EndoPredict to guide treatment in early HR+/HER2- breast cancer

  This tests whether the EndoPredict genomic test can predict 10-year relapse risk and help decide if people with early HR+/HER2- breast cancer need chemotherapy in addition to hormone therapy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07379918

• Biopsychosocial approach for acute low back pain in the emergency department

  This trial tests a biopsychosocial treatment plan for adults with acute non-traumatic lower back pain who come to the emergency department.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07375914

• Outcomes for couples after unsuccessful PGD at the Paris PGD Center

  This project will see what happens next for couples who started PGD at the Paris center but did not have a live birth from that care.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clamart · NCT07371312

• Short preoperative stereotactic radiotherapy to prevent pancreatic leaks after Whipple surgery

  This trial will test whether a short course of stereotactic radiotherapy given before a Whipple operation can reduce the chance of a pancreatic leak (fistula) in adults having a pancreaticoduodenectomy.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07370987

• Blood ctDNA testing to monitor treatment in children and young adults with classical Hodgkin lymphoma

  This project tests whether a blood test that detects circulating tumor DNA can monitor treatment response and help predict relapse in children and young adults with classical Hodgkin lymphoma.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07356882

• Measuring how well patients follow daily oral medicines in Necker’s inherited metabolic diseases department

  This project will measure how well children, adolescents, and young adults with inherited metabolic diseases at Necker follow their daily oral medicines to see if a medication-education workshop is needed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07356557

• Immunological and inflammation markers linked to ICU patient outcomes

  This study will try to see if certain immune and inflammation markers taken from adults admitted to intensive care can predict one-year survival and the risk of hospital-acquired infections.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07345169

• Body composition after daily versus long-acting growth hormone in children

  See if long-acting versus daily growth hormone changes body weight and body composition in children aged 3–17 with isolated growth hormone deficiency.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07333521

• Home treatment for adults with active cancer and stable pulmonary embolism without HESTIA criteria

  This trial will try treating adults with active cancer and a stable pulmonary embolism at home instead of in hospital to see if 14-day results are as safe.

  Recruiting at 15 sites Assistance Publique - Hôpitaux de Paris · Colombes, France and 19 other locations · NCT07315347

• Nasal airflow to ease breathing for tracheostomized patients on ventilators

  This study tests three non-drug methods to restore nasal stimulation and see if they reduce breathlessness in adults with tracheostomies who are dependent on mechanical ventilation.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07308171

• Does remembering pre-surgery information about mechanical valve noise affect quality of life after valve replacement?

  See if remembering the pre-surgery explanation about mechanical valve noise changes how bothered adults with Marfan syndrome and an aortic mechanical valve feel afterward.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07304115

• Checking whether an adductor canal injection spreads to the tibial and fibular branches of the sciatic nerve.

  For adults having elective knee surgery with an adductor canal block, this will test if the local anesthetic spreads to the tibial and fibular branches of the sciatic nerve.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt · NCT07301476

• Gut bacteria and immune-cell energy in people with IBD and healthy adults

  We will test whether gut bacteria change how immune cells use energy in people with Crohn's disease or ulcerative colitis and in healthy adults by using a short antibiotic course and a labeled fiber.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07300553

• Developing a leading interdisciplinary care model for people with MS that can be adapted to different local settings.

  This project will see if a leading interdisciplinary care model can improve coordination, quality, and patient experience for people with MS, their carers, and the teams that treat them.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07289724

• Skin and gut microbiome study in Netherton syndrome

  This study tests whether the skin, gut, and oral microbiomes differ in people with Netherton syndrome compared to those without the condition.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07280091

• Brain–lung interaction during sudden severe low-oxygen respiratory failure

  We will try EEG, NIRS, and neck muscle recordings before and one hour after starting high-flow nasal oxygen in adults with sudden low-oxygen respiratory failure to see how the brain and lungs interact.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07279831

• Obinutuzumab for non-infectious cryoglobulinemic vasculitis that didn’t respond to rituximab

  This study tests whether obinutuzumab can help adults with active cryoglobulinemic vasculitis who are refractory or intolerant to rituximab.

  Recruiting at 23 sites Phase 2 Assistance Publique - Hôpitaux de Paris · Blois and 24 other locations · NCT07268521

• Measuring airway opening pressure in invasively ventilated children

  This project tries two methods to measure airway opening pressure in children on invasive mechanical ventilation to see if the measurements are feasible.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07262541

• Integrating clinical, lab, and biopsy data to predict outcomes in acute alcoholic hepatitis

  This project will try to see if combining clinical information, blood tests, and biopsy findings can better predict outcomes for adults diagnosed with acute alcoholic hepatitis.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07262515

• Endorotor versus standard endoscopic removal for walled-off pancreatic necrosis

  This trial will try whether using the Endorotor device helps adults with infected or symptomatic walled-off pancreatic necrosis recover faster or with fewer procedures than standard endoscopic necrosectomy after drainage.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clichy · NCT07253350

• Rapid test for Candida auris detection in hospital patients

  This study tests a quick rapid diagnostic test to see if it can correctly identify Candida auris in patient samples compared with the standard lab method.

  Recruiting Assistance Publique - Hôpitaux de Paris · Athens · NCT07253311

• Tracking development, seizures, and biomarkers over four years in children and young adults with SCN1A-related Dravet syndrome

  This project will follow children and young people with SCN1A-related Dravet syndrome for four years to see how their development, seizure patterns, and blood metabolite markers change over time.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Ap-hp / DRCI · NCT07251673

• Initial dual oral therapy versus monotherapy for PAH with cardiovascular comorbidities

  This trial will test whether starting both tadalafil and ambrisentan together works better than tadalafil alone for people newly diagnosed with pulmonary arterial hypertension who have at least two heart or vascular health problems.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre · NCT07245680

• Rapid nose-swab test for COVID-19, influenza, and RSV to reduce unnecessary antibiotic use

  This will test whether a quick nose-swab that detects COVID-19, flu, and RSV helps doctors avoid prescribing antibiotics for people aged 1 and older with recent respiratory symptoms.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT07243249

• National insurance funding to increase vaccination in outpatient care

  This project will try giving vaccines paid for by the national health insurance in outpatient visits at several hospitals to see if it raises pertussis vaccination in pregnant women and pneumococcal vaccination in eligible adults.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, IDF and 5 other locations · NCT07243236

• Long-term outcomes for people with immune TTP in the French national TMA cohort

  This project uses past medical records to see long-term health outcomes and complications in people in France who had immune thrombotic thrombocytopenic purpura (iTTP).

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07205861

• Combined decontamination with charcoal and PEG in severe poisoning

  A 2nd-phase trial tests whether giving activated charcoal plus polyethylene glycol to adults with severe poisoning in ICU reduces blood levels of the toxic drug within 24 hours compared with standard care.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07201311

• Lowering the total dose of cyclophosphamide after haploidentical stem cell transplant for blood cancers

  This trial tests whether a reduced total dose of cyclophosphamide after a haploidentical stem cell transplant can improve outcomes for adults with blood cancers.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT07193420

• Fampridine versus placebo for adults with SCA27B caused by an FGF14 GAA expansion

  This trial tests whether fampridine (4-aminopyridine) can improve walking and visual symptoms in adults who have SCA27B from a GAA expansion in the FGF14 gene.

  Recruiting at 4 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Angers and 8 other locations · NCT07185347

• Therapeutic education to help self-image in adults with inflammatory rheumatic diseases

  This study tests a therapeutic education program aimed at improving how adults with inflammatory rheumatic diseases view themselves.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07170826

• Cognition and Lung Cancer: Seeing How Thinking Changes After Localized NSCLC Treatment

  This observational study tests whether cognitive problems emerge or change over time in adults treated for localized operable non-small cell lung cancer.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07160751

• Clareon PanOptix versus AcrySof PanOptix for contrast vision after cataract surgery

  This study will try Clareon PanOptix in one eye and AcrySof PanOptix in the other to see which lens gives better contrast vision three months after cataract surgery for adults seeking presbyopia correction.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07158177

• Cardiovascular problems after allogeneic stem cell transplant

  This study looks at heart-related problems after allogeneic hematopoietic stem cell transplantation to see how often they occur and what factors might predict them.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07157670

• How SeqOIA and AURAGEN genomic sequencing affects cancer care pathways

  This project tests whether genomic sequencing performed by the SeqOIA and AURAGEN platforms changes care and treatment recommendations for cancer patients referred for high‑throughput sequencing.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Lyon and 2 other locations · NCT07147465

• Six-year outcomes for children exposed to nifedipine or placebo after early preterm membrane rupture

  This follow-up will test whether a short course of nifedipine given before birth affects neurodevelopment at age 6 in children born after preterm rupture of membranes at 22–33 weeks.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT07146451

• Standardizing tests that detect spatial neglect.

  This project will test neuropsychological tasks in healthy French-speaking adults to create reference scores that help clinicians decide when a person has spatial neglect.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garche · NCT07145970

• High-resolution MRI of paravertebral (back) muscles in children with idiopathic or neuromuscular scoliosis

  We will use a short, extra high-resolution MRI to see if differences in the deep back muscles are linked to scoliosis in children aged 10–17 with idiopathic or neuromuscular forms.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT07135765

• B cells in antibody-mediated kidney transplant rejection: their characteristics and what they react to.

  This project will test whether B cells taken from kidney transplant patients with suspected antibody-mediated rejection produce antibodies that react to donor HLA, other targets, or gut microbes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07134491

• Using walking sticks to increase walking in people with forward spinal imbalance

  This study will try using walking sticks to help adults with forward (sagittal) spinal imbalance walk farther and with better stability.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07127250

• Extended prone positioning for adults with severe ARDS on mechanical ventilation

  This trial tests whether keeping intubated adults with severe ARDS prone for about 40 hours per session lowers deaths compared with the standard ~16-hour sessions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07126964

• Understanding neurodevelopment in dystrophinopathies to guide personalized care

  Researchers are testing whether cognitive and behavioral features in children with DMD align with their genetic differences, and if tailored cognitive strategies can help.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT07125898

• Chronotherapy plus light therapy and melatonin for major depressive episode with insomnia

  This study tests whether adding light therapy and extended-release melatonin to standard care helps adults with a major depressive episode and insomnia see faster and better mood and sleep improvements.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT07120880

• Multicenter study of SHANK3-related Phelan-McDermid syndrome genetic modifiers

  Researchers are testing how other genes may modify the PMS clinical picture in people with SHANK3-related deletions or variants.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Ap-hp / DRCI · NCT07119606

• Prosthetic joint infection patterns in critically ill patients who died

  This project looks at health records of adults who died in intensive care with a hip, knee, or shoulder prosthetic joint infection from 2018–2022 to see common care paths and outcomes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT07107685

• Balancing while picking up objects for people with hemiparesis

  We will test whether shifting more weight onto the stronger leg helps people with hemiparesis stay steadier when picking up objects from the ground.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT07082036

• Locus Coeruleus and PHOX2B Mutations in Ondine Syndrome

  Researchers will see if cognitive issues in young people with Ondine Syndrome relate to the severity of their PHOX2B mutation and dysfunction in the locus coeruleus by using EEG, pupil measurements, MRI, cognitive tests, and heart rate data.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Ap-hp / DRCI · NCT07081464

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Temocillin pharmacokinetics in kids with febrile urinary tract infection

  This study tests how temocillin behaves in the bodies of children aged 0-15 with febrile UTIs due to Gram-negative bacteria who need hospitalization.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Ap-hp / DRCI · NCT07070102

• Non-invasive ventilation or CPAP for COPD with sleep apnea after a serious COPD flare

  This study tests whether non-invasive ventilation (NIV) or CPAP can help adults with COPD and coexisting obstructive sleep apnea after a severe COPD flare requiring hospital care.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT07047092

• How well the shingles vaccine works for adults with immune-mediated systemic inflammatory diseases

  This will test whether the recombinant shingles vaccine (Shingrix) produces an antibody response in adults with immune-mediated systemic inflammatory diseases who are on immunosuppressive therapy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07047053

• Ovarian reserve in women with the FMR1 (Fragile X) premutation

  We will track ovarian reserve over time in women aged 18–40 who carry the FMR1 premutation to see if early markers predict later ovarian decline.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT07039734

• Oral SPM-enriched marine oil to reduce inflammation-driven vascular ageing in obese people with high blood pressure

  This trial tests whether taking an oral SPM-enriched marine oil supplement (LIPINOVA) can reduce blood-vessel inflammation and signs of vascular ageing in adults with obesity and controlled hypertension.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07038252

• Long-term follow-up of cardiac arrest survivors treated with ultra-rapid cooling

  This follow-up will see if people who survived cardiac arrest after ultra-rapid cooling with Vent2Cool have better long-term function and quality of life.

  Recruiting Assistance Publique - Hôpitaux de Paris · Angers and 1 other locations · NCT07028372

• Iron buildup and liver problems in adults more than 10 years after an allogeneic stem cell transplant

  This project will see if long-term iron buildup raises the risk of liver complications in adults who had an allogeneic stem-cell transplant at least 10 years ago.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07028112

• Early preventive left ventricle unloading after peripheral VA-ECMO for refractory cardiogenic shock

  This study will try early left ventricular unloading in adults on peripheral VA-ECMO for severe cardiogenic shock to see if it reduces lung congestion and helps the heart recover.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clermont-Ferrand and 11 other locations · NCT07027202

• Dapagliflozin to protect the heart and kidneys after ICU discharge

  We will test whether taking dapagliflozin for one year after leaving the ICU reduces later heart and kidney complications in adults who had severe critical illness.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07025629

• Direct extubation versus extubation after a spontaneous breathing trial in low-risk patients

  This trial tests whether skipping a spontaneous breathing trial and directly extubating is safe and helps more patients come off the ventilator within 24 hours in people who are ready to wean and at low risk of extubation failure.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07019636

• Epithelial Dysmetabolism and Kidney Fibrosis in ANCA Vasculitis

  This study tests whether alterations in tubulo-interstitial metabolism relate to how quickly kidney function deteriorates in people with ANCA-associated vasculitis compared to other nephropathies.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07010250

• Direct oral antibiotic challenge to remove beta-lactam allergy label in children in private clinics

  This study will try giving a supervised small dose of a beta-lactam antibiotic in private pediatric clinics to see if children labeled as allergic actually tolerate it.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07002814

• Research on blood markers linked to fatigue in patients with low platelet counts

  This study is trying to see if certain blood markers are linked to fatigue in people with low platelet counts.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06979765

• Non-invasive continuous blood pressure monitoring during carotid endarterectomy

  This test will see if a non-invasive digital cuff can continuously track blood pressure as accurately as an arterial catheter in adults having carotid endarterectomy under general anesthesia.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, France · NCT06965257

• High-definition surface electromyography to diagnose and monitor sarcopenia

  This project will try high-definition surface electromyography (HD-sEMG) to see if it can diagnose and monitor sarcopenia in people aged 75 and older who score ≥4 on the SARC-F screening questionnaire.

  Recruiting at 10 sites Assistance Publique - Hôpitaux de Paris · Issy-les-Moulineaux and 10 other locations · NCT06963359

• Memory abilities in people with disorders of consciousness

  This project tests whether brain (hdEEG) and heart (ECG) signals can reveal new memory formation in ICU patients with disorders of consciousness.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT06959212

• General practitioner‑offered low‑dose CT screening for lung cancer

  This trial tests whether offering yearly low‑dose CT screening through your general practitioner will increase screening participation among high‑risk smokers aged 50–74.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06956040

• Posterior staphyloma risk and anatomy in Europeans with high myopia

  This project will try to find genetic differences and blood markers linked to posterior staphyloma in adults of European descent who have high myopia.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06949579

• Obinutuzumab to induce remission in relapsing PR3-ANCA granulomatosis with polyangiitis

  This trial will try obinutuzumab to bring about clinical and blood-marker remission in adults with relapsing PR3-ANCA granulomatosis with polyangiitis.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT06940661

• Cochlear implant for children with single-sided or asymmetric hearing loss

  This trial will test whether cochlear implants help children aged 4–6 with unilateral or asymmetric hearing loss improve speech understanding in noise and sound localization.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06930170

• Why some cases of IgA nephropathy resist conventional and new therapies: a real-life observational look

  This project will collect real-world data from adults with biopsy-proven IgA nephropathy to see which patients keep having proteinuria or kidney decline despite modern nephroprotective measures and newer treatments.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06926244

• Lung cancer and cellular aging markers — prospective cohort

  We will test whether aging and senescence markers measured in blood and tissue can help predict outcomes for people aged 70 and older who are having curative surgery for early to locally advanced non-small cell lung cancer.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Île-de-France Region · NCT06923618

• Defining pneumonia subtypes by respiratory microbiome to predict treatment failure

  This project will see if patterns in the respiratory microbiome can predict antibiotic or clinical treatment failures in adults hospitalized with community-acquired or hospital-acquired pneumonia.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clichy and 5 other locations · NCT06916481

• Liver transplant after SIRT and chemotherapy for locally advanced intrahepatic cholangiocarcinoma

  This trial tries to see if SIRT and chemotherapy followed by a liver transplant helps people with unresectable, non-metastatic intrahepatic cholangiocarcinoma live longer.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clichy-sous-Bois · NCT06910722

• Impact of vestibular function on daily activities of deaf infants

  This study tests how vestibular problems affect daily tasks in deaf children aged 0–2 years.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06909266

• Evaluating new biomarkers for chronic Hepatitis B infection management

  This study is testing new blood markers to see if they can help doctors better manage chronic Hepatitis B and predict serious health issues for patients receiving care at a hospital.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Créteil · NCT06906016

• Two Botox injections plus custom rigid splinting for painful base-of-thumb osteoarthritis

  This trial tests whether two ultrasound-guided Botox injections together with a custom rigid splint reduce thumb-base pain in adults with base-of-thumb osteoarthritis.

  Recruiting Phase 2/3 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06902805

• Digital management of children's asthma with connected inhalers and video visits

  This pilot will test whether connected inhalers that trigger doctor video consultations can help manage asthma in children aged 4–12 compared with usual care.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06902766

• Parenting with 21‑hydroxylase congenital adrenal hyperplasia

  This study uses phone questionnaires to see how 21‑hydroxylase CAH affects fertility, pregnancy outcomes, and parenting in adults with genetically confirmed disease.

  Recruiting at 7 sites Assistance Publique - Hôpitaux de Paris · Bordeaux and 6 other locations · NCT06900153

• Time-restricted eating and immune function in women with severe obesity

  This trial tests whether following an 8-hour time-restricted eating schedule improves immune function in women aged 18–64 with severe obesity compared with a longer, 14-hour eating window, using a healthy lean group for reference.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT06899997

• Better testing for Pneumocystis in people with weakened immune systems

  This project will try a new qPCR test on non-invasive respiratory samples to see if it can detect Pneumocystis in immunocompromised adults compared with standard reference tests.

  Recruiting at 4 sites Assistance Publique - Hôpitaux de Paris · Paris and 3 other locations · NCT06890078

• Glycerol phenylbutyrate (Ravicti) for pyruvate dehydrogenase deficiency

  This trial will try glycerol phenylbutyrate (Ravicti) in children and young adults with confirmed pyruvate dehydrogenase deficiency to see if it improves fatigue, development, and seizure control.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris, France · NCT06887777

• Evaluating the long-term effects of a booster dose of MVA-BN vaccine for monkeypox

  This study is testing how well a booster dose of the MVA-BN vaccine works over time in men over 18 who have already had two doses to help protect against monkeypox.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT06885853

• Preventing RSV in infants born in France during the 2024–2025 season

  This questionnaire will see if infants born in metropolitan France between October 1, 2024 and January 31, 2025 are reached by and receive new RSV prevention measures such as nirsevimab or vaccines.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06881953

• Susac Syndrome: common features and possible causes

  This project will collect clinical, imaging, and laboratory information from adults with Susac Syndrome to try to identify typical symptoms, patterns, and possible causes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06881368

• Dexmedetomidine versus Midazolam to shorten time on the ventilator in very preterm infants

  This trial will test whether using dexmedetomidine instead of midazolam helps very preterm infants on invasive mechanical ventilation be extubated sooner.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06878703

• Cellular response after hepatitis B vaccination

  This project will test how adults' immune cells, especially T cells, change after receiving a hepatitis B vaccine.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06876467

• Breathlessness during ventilator weaning in obese ICU patients

  This project will measure how often and how severe breathlessness is when obese ICU patients try to breathe on their own during ventilator weaning.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT06867354

• Using Tai Chi and relaxation techniques to help adolescents with unexplained physical symptoms

  This study tests if Tai Chi and relaxation techniques can help teenagers with unexplained physical symptoms feel better and improve their quality of life.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Créteil · NCT06865833

• Evaluation of follow-up care for adults with esophageal atresia

  This study is testing a new follow-up care program for adults with esophageal atresia to see if it helps improve their overall quality of life and manage issues like PTSD.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06860919

• Comparing new immunotherapies and donor stem cell transplant as first treatment for adults with acute lymphoblastic leukemia

  This study will test whether adding newer immunotherapy drugs and/or using donor stem cell transplant up front improves outcomes for adults (18–65) newly diagnosed with acute lymphoblastic leukemia.

  Recruiting Phase 2/3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06860269

• Group cognitive behavioral therapy integrated with usual care for adults with ADHD and substance use disorder

  This program will test whether adding group cognitive behavioral therapy to usual care helps adults who have both ADHD and a moderate-to-severe substance use disorder.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06858527

• Observational study of patients with fibrosing interstitial lung disease in intensive care for respiratory failure

  This study looks at patients with fibrosing lung diseases who end up in intensive care for breathing problems to see how many survive after six months and what factors might affect their chances.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bobigny · NCT06855004

• Personalized PEEP and Prone Positioning in Severe ARDS

  This trial tests whether tailoring PEEP levels and using prone positioning with or without muscle relaxation can improve outcomes for adults with severe ARDS in the ICU.

  Recruiting at 29 sites Assistance Publique - Hôpitaux de Paris · Aix-en-Provence and 28 other locations · NCT06849570

• 30-day outcomes for cancer patients treated in specialist versus non-specialist emergency departments

  This study will see if adults with active cancer or cancer remission within the past year who go to a specialist cancer emergency department have different 30-day death and complication rates compared with those who go to non-specialist emergency departments.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06834646

• IV iron vs oral iron after cesarean for anemia and postpartum depression

  This study tests whether intravenous iron is better than oral iron at reducing postpartum depression in women who have moderate iron deficiency anemia after cesarean delivery.

  Recruiting Phase 4 Assistance Publique - Hôpitaux de Paris · Paris · NCT06833788

• Which parts of the immune system protect adults with major burns from fungal infections

  This research will test whether patterns in patients' immune systems explain why some adults with serious burns develop invasive fungal infections and others do not.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06828458

• How the immune system affects a person's sensitivity to radiotherapy.

  This project tests whether differences in patients' immune cells are linked to who does or does not develop severe side effects after radiotherapy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Île-de-France Region · NCT06826066

• 3D Ephemeris to support time orientation in Alzheimer's

  This project tests whether a 3D calendar device called the Ephéméride 3D can help people aged 65 and older with mild to moderate Alzheimer's or related dementias stay oriented to the day and time during hospitalization.

  Recruiting Assistance Publique - Hôpitaux de Paris · Champcueil · NCT06824142

• Endurance training for patients with sickle cell disease

  This study is testing whether a long-term endurance training program can help improve health, fitness, and quality of life for both adults and children with sickle cell disease.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06823219

• Non-invasive diagnosis for idiopathic nephrotic syndrome using blood antibodies and a routine-data score

  This project will test whether blood antibody tests together with a routine-data score (SNIT) can diagnose idiopathic nephrotic syndrome without a kidney biopsy in adults with a first episode who are anti-PLA2R negative.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT06820866

• Tocilizumab for Acute Chest Syndrome in Sickle Cell Disease

  This study tests whether a single infusion of tocilizumab can help people with sickle cell disease and acute chest syndrome come off oxygen and respiratory support faster.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06818266

• Predicting language recovery in stroke patients

  This study is testing if a new language assessment can help predict how well stroke patients will recover their language skills soon after their stroke.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06817642

• Using near apneic ventilation with ECMO for severe respiratory distress

  This study is testing if a new way of breathing support called near apneic ventilation can help patients with severe respiratory distress on ECMO recover better and faster than the usual care.

  Recruiting at 11 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Bobigny and 10 other locations · NCT06814340

• Using ultrasound to guide heart procedures in patients with kidney disease

  This study is testing whether using ultrasound to guide heart procedures can help people with kidney disease avoid serious complications from traditional methods that use contrast dye.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Creteil and 1 other locations · NCT06813534

• Identifying biomarkers in kidney disease before and after transplantation

  This study is trying to find specific markers in urine, blood, and tissue that can help doctors better diagnose and predict kidney disease before and after a transplant.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06810258

• Using a short questionnaire to identify who sticks with transanal irrigation (TAI)

  This project tests a short French questionnaire to see if it can identify adults using transanal irrigation who stick with the treatment and those who stop.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06805903

• Observational study on the health of children in protective services

  This study looks at the health and development of children recently placed in protective services in France to see how a special health program helps them compared to those who don’t receive it.

  Recruiting at 7 sites Assistance Publique - Hôpitaux de Paris · Évreux, France and 6 other locations · NCT06805682

• Assessing venous congestion in ARDS patients using ultrasound

  This study is testing if using ultrasound can help find out how common venous congestion is in patients with acute respiratory distress syndrome who are on mechanical ventilation.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, Val de Marne · NCT06805409

• Improving lung function during chest physiotherapy for patients on mechanical ventilation

  This study is testing if a special breathing technique can help improve lung function in patients on mechanical ventilation by comparing two different ways of supporting their breathing.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil · NCT06805357

• Understanding pregnancy outcomes in craniopharyngioma patients

  This study looks at how pregnancy affects people with craniopharyngioma, a rare brain tumor, by gathering experiences from those who have been diagnosed or treated for it.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06801756

• Exploring the experiences of parents after fetal surgery for myelomeningocele

  This study is trying to understand how parents feel and what decisions they make before and after having surgery on their unborn baby to fix myelomeningocele.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT06796972

• Screening tool for anal cancer detection using host genome methylation

  This study is trying to create a new screening tool for anal cancer that uses genetic markers to help high-risk groups, like men with HIV and women with past cancer, get tested more easily.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region and 8 other locations · NCT06792604

• Lab validation of immune cell therapy for MCPyV-positive Merkel cell carcinoma

  The team will test a lab-based immune cell therapy on tumor or blood samples from adults with MCPyV-positive Merkel cell carcinoma to see how the cells respond.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt · NCT06780475

• Steroids with or without the blood thinner rivaroxaban for deep vein clots in Behçet's syndrome

  This trial will try adding the blood thinner rivaroxaban to steroid treatment to see if adults with Behçet's syndrome and deep vein thrombosis have fewer recurrences or long-term leg problems than with steroids alone.

  Recruiting at 17 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Bordeaux and 16 other locations · NCT06780462

• Monitoring the effects of encorafenib and binimetinib in melanoma treatment

  This study is testing how the levels of two melanoma drugs, encorafenib and binimetinib, affect side effects and treatment success in adults with a specific type of advanced melanoma.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt · NCT06774989

• Bringing handheld echOpen ultrasound to link neighborhood clinics with Jean Verdier Hospital

  This project will test using a handheld echOpen ultrasound probe by hospital and community clinicians to see if it shortens time to diagnosis for adults referred to Jean Verdier's Rapid Diagnostic Unit.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bondy · NCT06774924

• Quality of life after Billroth II or Roux-en-Y for distal gastric cancer

  This study tests whether Billroth II or Roux-en-Y reconstruction after distal gastrectomy affects quality of life in adults with distal gastric cancer.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT06768164

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Assistance Publique - Hôpitaux de Paris are recruiting right now?

536, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in France (535 trials), Belgium (2 trials), Germany (2 trials), Italy (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 65, Phase 2: 26, Phase 1/2: 8, Phase 4: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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