Prosthetic joint infection patterns in critically ill patients who died

Osteoarticular Sepsis In Intensive Care Units : a Retrospective Study About Deceased Patients.

This project looks at health records of adults who died in intensive care with a hip, knee, or shoulder prosthetic joint infection from 2018–2022 to see common care paths and outcomes.

Quick facts

• Study type: Observational
• Enrollment: 150 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Assistance Publique - Hôpitaux de Paris (other)
• Locations: 1 site (Paris, France)
• Trial ID: NCT07107685 on ClinicalTrials.gov

What this trial studies

This is a retrospective, multicenter review of demographic, clinical, and biological data from adults who died after at least 48 hours in critical care with a prosthetic joint infection between 2018 and 2022. Data from deceased patients will be combined with the OASIS cohort of living critical-care patients with osteoarticular sepsis to broaden comparisons. The analysis will describe patient profiles, care trajectories, microbiology, and outcomes to identify patterns linked to worse prognosis. Results aim to inform identification of at-risk populations and potential improvements in critical-care management of infections involving prosthetic material.

Who should consider this trial

Good fit: Adults aged 18 or older who were hospitalized in an intensive care or continuing care unit for at least 48 hours between 2018 and 2022 and died with a primary or associated diagnosis of hip, knee, or shoulder prosthetic joint infection, provided they did not refuse data use.

Not a fit: Patients with infections of osteosynthesis material or spinal instrumentation, those with multiple infected prostheses, recurrent infections with the same microorganism, persons under legal protection, pregnant or breastfeeding patients, and those deprived of liberty were excluded and therefore will not be represented in the dataset.

Why it matters

Potential benefit: If successful, the results could help clinicians identify high-risk patients earlier and refine management strategies to reduce complications and deaths from prosthetic joint sepsis.

How similar studies have performed: Previous cohort and registry studies of prosthetic joint infections have identified risk factors and outcomes, and combining deceased-patient data with the OASIS living-patient cohort follows established epidemiologic methods although analysis focused on deceased critical-care patients is less common.

Eligibility criteria

Inclusion Criteria:

* Patient aged 18 years or older.
* Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022, lasting at least 48 hours, with a prosthetic joint infection (hip, knee, or shoulder prosthesis infection) as the primary or associated diagnosis.
* Deceased patient who had not refused data processing.

Exclusion Criteria:

* Infection involving osteosynthesis material
* Infection involving spinal instrumentation
* Patient with multiple infected prostheses
* Recurrence of prosthetic infection with the same microorganism as a previous episode
* Patient under legal protection
* Pregnant or breastfeeding patient
* Patient deprived of liberty

Where this trial is running

Paris, France

• Hôpital Lariboisière — Paris, France, France (RECRUITING)

Study contacts

• Study coordinator: Benjamin SOYER, MD, Msc

Conditions: Osteoarticular Infections, Intensive Care Patients, Prosthetic Joint Infection, Osteoarticular sepsis, sepsis, osteoarticular prothetis, intensive care, critical care