Prosthetic joint infection patterns in critically ill patients who died

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective, multicenter review of demographic, clinical, and biological data from adults who died after at least 48 hours in critical care with a prosthetic joint infection between 2018 and 2022. Data from deceased patients will be combined with the OASIS cohort of living critical-care patients with osteoarticular sepsis to broaden comparisons. The analysis will describe patient profiles, care trajectories, microbiology, and outcomes to identify patterns linked to worse prognosis. Results aim to inform identification of at-risk populations and potential improvements in critical-care management of infections involving prosthetic material.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient aged 18 years or older.
* Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022, lasting at least 48 hours, with a prosthetic joint infection (hip, knee, or shoulder prosthesis infection) as the primary or associated diagnosis.
* Deceased patient who had not refused data processing.

Exclusion Criteria:

* Infection involving osteosynthesis material
* Infection involving spinal instrumentation
* Patient with multiple infected prostheses
* Recurrence of prosthetic infection with the same microorganism as a previous episode
* Patient under legal protection
* Pregnant or breastfeeding patient
* Patient deprived of liberty

Where it's running

• Hôpital Lariboisière
  Paris, France, France Recruiting

Study contacts

• Study coordinator: Benjamin SOYER, MD, Msc
• Email: benjamin.soyer@aphp.fr
• Phone: +33 1 49 95 85 15

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How knee and hip joint replacements are doing over time

  This observational study follows adults who have knee or hip replacements to see how their outcomes look over time after the surgery.

  Recruiting University Hospital, Bonn · Bonn, North Rhine-Westphalia · NCT07799818

• Population pharmacokinetics of rifampicin in staphylococcal osteoarticular infections

  This study tests how rifampicin behaves in the body of adults with staphylococcal osteoarticular infections when given with levofloxacin or ciprofloxacin, to see how drug exposure relates to tolerance and outcomes.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Paris · NCT07788404

• Reducing bacterial contamination during primary shoulder replacement

  This trial tests whether putting Prontosan antimicrobial gel on the dermal layer after the skin is cut can lower Cutibacterium acnes growth in men having primary shoulder replacement.

  Recruiting St. Louis University · St Louis, Missouri · NCT07406893

• Immunological and inflammation markers linked to ICU patient outcomes

  This study will try to see if certain immune and inflammation markers taken from adults admitted to intensive care can predict one-year survival and the risk of hospital-acquired infections.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07345169

• Methylene blue dye to measure how much irrigation clears contamination during knee replacement procedures

  We will test whether putting methylene blue dye into the knee during replacement or DAIR procedures can show how much irrigation is needed to wash out contaminants.

  Recruiting Phase 1 University of Miami · Miami, Florida · NCT07324954

• PLG0206 irrigation to prevent repeat knee replacement infections after DAIR

  This will test if washing the knee with PLG0206 during a DAIR procedure can lower the chance that a prosthetic knee infection comes back in adults who had a knee replacement.

  Recruiting at 19 sites Phase 2/3 Peptilogics · Sarasota, Florida and 20 other locations · NCT07214311

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.