Endurance training for patients with sickle cell disease
Official title: Evaluation of a Long-term Endurance Training Program in Patients With Sickle Cell Disease: Benefits on Clinical Profile, Physical Fitness and Quality of Life of Patients
Run by Assistance Publique - Hôpitaux de Paris · NCT06823219 · Data updated 2026-11-12
This study is testing whether a long-term endurance training program can help improve health, fitness, and quality of life for both adults and children with sickle cell disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Créteil) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | October 1, 2024 |
| Study ends | October 1, 2028 |
| Registry record updated | February 12, 2025 |
| Trial ID | NCT06823219 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged over 15 years with a confirmed diagnosis of sickle cell disease who are in a stabilized condition.
✕Probably not a fit
Patients who are already engaged in regular physical activity or have unresolved chronic conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of a long-term endurance training program on patients with sickle cell disease (SCD), focusing on improvements in clinical profile, physical fitness, and quality of life. It aims to include a diverse cohort of both adult and pediatric patients, particularly those with complications, over a one-year period. The study builds on previous findings that moderate-intensity endurance training can be safe and beneficial for SCD patients, with the primary outcome being enhanced physical ability. Participants will undergo a structured training regimen designed to improve their overall health and fitness levels.
Why it matters
Potential benefit: If successful, this study could significantly enhance the physical fitness and quality of life for patients with sickle cell disease.
How similar studies have gone: Previous studies have shown positive outcomes with endurance training in sickle cell disease, indicating that this approach is promising and not entirely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged over 15 years and 3 months * Male or female * Patients with sickle cell disease (HbSS or HbS-βthal0) * Affiliated to a social security system * Having freely given their written consent after having been informed of the purpose, the procedure and the potential risks involved * Patients in stabilised condition at the start of the experiment: at least 1 month after an acute chronic event or at least 3 months after a blood transfusion. * Patients hospitalised for vaso-occlusive crisis at least once in the last 3 years Exclusion Criteria: * Patient whose adherence to the protocol is unlikely according to the investigator * Patients who already partake in regular physical activity (more than 1 hour of moderate-intensity physical activity per week) * Patients with a chronic inflammatory and/or infectious pathology * Patients with an intercurrent condition unresolved for less than a month * Patients hospitalised for cardiac decompensation during the last 12 months * Patients on anticoagulant treatment or with a pacemaker/defibrillator * Pregnant patients / breastfeeding woman * Patients deprived of liberty by judicial or administrative decision or patient under guardianship * Patients unable to understand the objectives and conditions of the study and unable to give cons
Where it's running
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Henri Mondor Hospital
Créteil, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.