Brain–lung interaction during sudden severe low-oxygen respiratory failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling non-intubated adults admitted to the ICU with de novo acute hypoxemic respiratory failure for whom clinicians start high-flow nasal cannula (HFNC). EEG, near-infrared spectroscopy (NIRS), and scalenus muscle EMG recordings will be collected immediately before and one hour after HFNC initiation. Researchers will extract EEG spectral densities across standard frequency bands from multiple cortical regions and combine these signals with NIRS and EMG data to characterize brain–ventilation interactions. The goal is to link brain signal changes to respiratory support response and provide physiological markers that could inform future management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Age ≥ 18 years
* Admitted to the intensive care within the last 48 hours
* De novo acute hypoxemic respiratory failure with an indication for high-flow nasal cannula (HFNC), defined by the combination of the following three criteria:

  * Tachypnea \> 25 breaths/min or labored breathing
  * PaO2 (partial pressure of oxygen ) /FiO2 ( fraction of inspired oxygen ) ≤ 200 mmHg
  * Unilateral or bilateral alveolar opacities on chest X-ray
* Decision by the attending physician to initiate HFNC treatment
* After information, the patient or next of kind did not refuse to participate (according to the French law, written informed consent is waived)

Exclusion Criteria:

* \- Exacerbation of an underlying chronic respiratory disease
* Acute cardiogenic pulmonary edema indicating non-invasive ventilation (NIV)
* Hypercapnia \> 45 mmHg indicating NIV
* Glasgow Coma Scale \< 13
* Imminent intubation
* Underlying central neurological disease likely to alter EEG signals
* Pregnancy or breastfeeding
* Lack of health insurance coverage
* Patient under legal protection

Where it's running

• Médecine Intensive - Réanimation, Hôpital Pitié Salpêtrière
  Paris, France Recruiting
• Service de Médecine Intensive et Réanimation, Hôpital Pitié Salpêtrière
  Paris, France Not yet recruiting

Study contacts

• Principal investigator: Alexandre Demoule — Aphp
• Study coordinator: Alexandre Demoule
• Email: alexandre.demoule@aphp.fr
• Phone: 0142167888

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.