Cognition and Lung Cancer: Seeing How Thinking Changes After Localized NSCLC Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will follow adults with localized, operable NSCLC to detect when cognitive complaints begin and how they progress after treatment. They will use self-questionnaires and standard cognitive tests to measure memory, attention, and processing speed, and assess how mood, fatigue, social factors, and vulnerability influence these symptoms. The study also looks at how cancer treatment, disease burden, and psychosocial stressors relate to Cancer-Related Cognitive Impairment and quality of life. Baseline cognitive function will be recorded before treatment to compare against later results. Participants will complete electronic assessments via a home-ready platform and may contribute data from multiple time points.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient aged 18 to 74 years
* Suspected or confirmed localized and operable non-small cell lung cancer (NSCLC)
* Surgical treatment with or without perioperative systemic medical therapy
* Ability to independently complete self-questionnaires via the Cleanweb platform
* Patients with access to a phone, tablet, or computer at home to complete the electronic self-questionnaires.

Exclusion Criteria:

* Known pre-existing cognitive disorders
* Presence on the day of inclusion of one or more factors causing mental confusion: electrolyte imbalances, renal failure, hepatic failure, infections, bladder distension, fecal impaction
* Known psychiatric or neurological diseases (e.g., multiple sclerosis, Parkinson's disease, dementia, stroke, traumatic brain injury with loss of consciousness)
* Current use of neuroleptic treatments
* History of cancer treatment within the past 10 years
* Fibromyalgia
* Individuals who cannot read French or are not French-speaking
* Patients who have never attended school

Where it's running

• Hôpital Cochin - Service de pneumologie
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Principal investigator: Isabelle HARDY LEGER — Hôpital Cochin, Assistance Publique-Hôpitaux de Paris - Service de pneumologie.
• Study coordinator: Isabelle HARDY LEGER
• Email: isabelle.leger@aphp.fr
• Phone: 01 58 41 24 01

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.