Rapid nose-swab test for COVID-19, influenza, and RSV to reduce unnecessary antibiotic use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses a point-of-care triplex rapid diagnostic test (TROD) performed via a nasal swab to detect SARS-CoV-2, influenza viruses, and RSV during outpatient consultations. Eligible participants are people age 1 and older presenting with recent fever or respiratory symptoms or suspected lower respiratory tract infection who are affiliated with the French national health insurance system. Test results are provided during the visit to inform the clinician’s decision about whether to prescribe antibiotics, with prescribing behavior and short-term clinical outcomes tracked afterwards. The aim is to see if rapid viral identification leads to fewer unnecessary antibiotic prescriptions and reduced antibiotic exposure in the community.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 1 year
2. Presenting with:

   * Either fever (temperature \> 38°C measured by patient or physician) within the past 72 hours, and one of the following symptom combinations:

     1. Rhinorrhea (white, yellow, or green discharge) and/or nasal obstruction, and cough
     2. Body aches, cough, and fatigue
     3. Odynophagia and negative strepto-test
     4. Cough
     5. Otalgia
   * Or suspicion of lower respiratory tract infection: signs of infection (respiratory rate \> 20/min, heart rate \> 100/min, fatigue, Body aches, chills, or fever), associated with pulmonary localization signs \[cough, sputum, chest pain, auscultatory abnormality (rhonchi, crackles, or wheezing)\]
3. Affiliation with the national health insurance system
4. Informed consent obtained from the adult participant, or from the person(s) with parental authority for a minor participant

Exclusion Criteria:

1. Requirement for hospitalization
2. Presence of a non-respiratory infection requiring concomitant antibiotic treatment.
3. Patients covered by State Medical Aid (AME)

Where it's running

• Assistance Publique - Hôpitaux de Paris
  Garches, France Recruiting

Study contacts

• Study coordinator: Aurélien DINH, MD, PhD
• Email: aurelien.dinh@aphp.fr
• Phone: +33 1 47 10 77 60

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.