Cellular response after hepatitis B vaccination

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling adults who will receive hepatitis B vaccination and have pre‑vaccination serology within four weeks of the first dose. Investigators will collect blood to isolate PBMCs, run serology, perform spectral cytometry to profile immune cell populations, and conduct RNA sequencing to examine gene-expression changes in responding cells. The protocol focuses on characterizing antigen-specific CD4+ and CD8+ T‑cell responses and other cellular signatures that accompany protective antibody development. Results will compare cellular and molecular profiles across participants to identify patterns linked to strong or weak vaccine responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥18 years
* Pre-vaccination HBV serology carried out within 4 weeks prior to vaccination
* Collection of no objection

Exclusion Criteria:

* Opposition of the person or inability to give opposition
* Pregnant or breast-feeding women
* Chronic illnesses affecting the individual's immune system (asplenia; hyposplenia; haematological cancer; auto-immune disease requiring immunosuppressive treatment, HIV infection).
* Non-affiliation with a social security scheme, Universal Medical Coverage or any equivalent scheme

Where it's running

• Hôpital Saint Louis AP-HP
  Paris, France Recruiting

Study contacts

• Study coordinator: Jérôme Le Goff, MD PhD
• Email: jerome.le-goff@aphp.fr
• Phone: 1 42 49 94 93

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.