Long-term follow-up of cardiac arrest survivors treated with ultra-rapid cooling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational long-term follow-up of adults who were enrolled in the OverCool investigation and received ultra-rapid cooling with the Vent2Cool system, with inclusion limited to those alive 28 days after cardiac arrest. Data collection includes patient-reported outcomes and functional measures such as the SF-36, modified Rankin Score, ADL questionnaire, NYHA class, and SGRQ, obtained with non-opposition/consent within three months after the parent study. The study is conducted at participating French centers (Angers University Hospital and AP-HP Cochin Hospital) and documents morbidity, mortality, and quality-of-life trajectories after post-cardiac arrest syndrome. The aim is to characterize long-term safety, functional recovery, and respiratory and cardiac status following ultra-rapid hypothermia induction by total liquid ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age of 18 years and over
* Cardiac arrest patient included in and alive at the end of the OverCool clinical investigation (28 days after the cardiac arrest)
* Non-opposition from the patient or the trusted person or the close relative or parent obtained within 3 months after the end of the OverCool study

Exclusion Criteria:

* Follow-up refusal from patient of trusted person or the close relative or parent
* Having being included in the OverCool clinical investigation but not submitted to the Vent2Cool procedure
* Impossibility to reach the patient or the trusted person or the close relative or parent

Where it's running

• AP-HP Centre, Cochin Hospital, Medical Intensive Care Unit
  Paris, France Recruiting
• Angers University Hospital, Medical Intensive Care Unit, Vent'Lab
  Angers, France Not yet recruiting

Study contacts

• Principal investigator: Alain CARIOU, MD PhD — AP-HP, Cochin Hospital, Intensive Care and Resuscitation Department
• Study coordinator: Alain CARIOU, MD PhD
• Email: alain.cariou@aphp.fr
• Phone: +33 1 58 41 25 01

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Measuring airway opening during out-of-hospital cardiac arrest

  This project tests whether the Airway Opening Index (AOI) measured from capnograms during CPR in adults with out-of-hospital cardiac arrest is common and linked to return of spontaneous circulation.

  Recruiting University Hospital, Ghent · Ghent, East-Flanders · NCT07438938

• Smartphone-based EEG to detect hidden awareness in ICU patients with brain injuries

  Researchers will test a smartphone-enabled EEG to see if it can reveal Cognitive Motor Dissociation in ICU patients who can’t show commands at bedside.

  Recruiting Columbia University · Miami, Florida and 8 other locations · NCT07917728

• Physiology-guided Epinephrine Dosing in Pediatric Cardiac Arrest

  This observational study looks at how a child’s body responds to epinephrine during in-hospital cardiac arrests to see if dosing can be guided by physiology.

  Recruiting at 22 sites Children's Hospital of Philadelphia · Orange, California and 21 other locations · NCT07890610

• Hand position during chest compressions: interlocked fingers vs. overlapped hands

  This study tests whether having hands interlocked or stacked on top of each other during CPR chest compressions is non-inferior in depth and is compared for comfort and fatigue in a simulated setting.

  Recruiting University of Pecs · Pécs · NCT07825805

• Risk of malignant arrhythmias after acute coronary syndrome

  This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07824050

• Hyperacute Neurobiomarker Kinetics in Acute Brain Injury: What Happens in Minutes After Injury

  This study tests how early brain injury biomarkers behave in the first minutes to hours after traumatic brain injury or cardiac arrest to see if they rise quickly enough to help with early care.

  Recruiting at 4 sites University of Pecs · Pécs, Branya and 3 other locations · NCT07782216

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.