Diffusion MRI to map nerve lesions in obstetric brachial plexus palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study uses diffusion tensor imaging to visualize the brachial plexus and characterize microstructural changes in unoperated obstetric brachial plexus palsy. The goal is to provide lesion assessment that could support decisions about surgical exploration. MRI with diffusion tensor imaging and tractography traces water diffusion to map nerve pathways in the upper limb. Participants are 14 to 30 years old with a single unoperated OBP lesion treated at Armand Trousseau Hospital. The study aims to improve imaging-based understanding of OBP and its potential implications for management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 14 to 30 years
* Consulted by the Orthopedics Department at Armand Trousseau Hospital
* Diagnosed and monitored by Armand Trousseau Hospital for obstetrical brachial plexus palsy (OBBP)
* Having a single, unoperated lesion (lesions are very different and only exceptionally affect all the roots bilaterally).
* Not suffering from bone or neurological pathology unrelated to OBP
* Patients affiliated with or entitled to a social security scheme
* Patients who have received informed information and have signed, with the investigator, a consent form to participate in the study
* Parents/legal guardians who have received informed information and have co-signed, with the investigator, a consent form to participate in the study, for minor patients

Exclusion Criteria:

* History of rheumatoid pathologies, constitutional bone diseases, past or current pathologies affecting the arm or neck unrelated to the obstetric brachial plexus, any history of neoplasia or radiographic appearance consistent with a neoplastic fracture
* Current pregnancy
* Inability to perform the MRI examination (presence of a contraindication, incapacitating pain, or claustrophobia)
* Large tattoo present in the area of interest (artifacts)
* Patients deprived of liberty, or under guardianship/curatorship
* Patients receiving medical assistance (AME)

Where it's running

• Service de Chirurgie Orthopédique et Réparatrice de l'Enfant, Hôpital Armand Trousseau AP-HP
  Paris, France Recruiting

Study contacts

• Principal investigator: Manon BACHY-RAZZOUK, PU-PH — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Manon BACHY-RAZZOUK, PU-PH
• Email: manon.bachy@aphp.fr
• Phone: 00 33 1 44 73 69 37

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.