Posterior staphyloma risk and anatomy in Europeans with high myopia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-center, cross-sectional project will enroll 600 European adults with high myopia across three centers in France, Spain, and the Netherlands and collect blood for DNA and standardized retinal imaging. Participants will be divided into 300 with posterior staphyloma and 300 without, and a genome-wide association study (GWAS) will compare SNP frequencies between the two groups while adjusting for age, sex, axial length, and genetic ancestry. Significant loci will undergo functional annotation and pathway enrichment analyses, and exploratory analyses will relate genetic findings to retinal imaging phenotypes. All clinical and genetic data will be entered into a centralized Castor database under a harmonized protocol to ensure uniform phenotyping.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with and without posterior staphyloma

  * Adults aged 18 years or over
  * Patient with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with good quality retinal imaging
  * Patient who has signed a consent form to participate in the study
  * Patient who is a beneficiary of a social security scheme or who is entitled to it

Exclusion Criteria:

* Any systemic or ocular pathologies with an impact on the posterior segment of the eye

  * Patient with a systemic pathology likely to affect the posterior segment of the eye:
  * Diabetes
  * Systemic inflammatory disease: sarcoidosis, rheumatoid arthritis, systemic lupus erythematosus, Horton's disease
  * Patients with retinitis pigmentosa
  * Patients with syndromic myopia
  * Patients with myopia associated with a genetic disease such as hereditary vitreoretinopathy
  * Patients under guardianship, curatorship or legal protection, as well as pregnant or breastfeeding women (article L1121-5 of the CSP).

Where it's running

• Cochin Hospital
  Paris, France Recruiting

Study contacts

• Principal investigator: Francine BEHAR-COHEN, MD,PhD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Francine Behar-Cohen, MD, PhD
• Email: francine.cohen@aphp.fr
• Phone: 06 60 97 44 19

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.