High-resolution MRI of paravertebral (back) muscles in children with idiopathic or neuromuscular scoliosis
Official title: Paravertebral Muscles Assessment Using High-resolution MRI in Children Suffering From Idiopathic or Neuromuscular Scoliosis
Run by Assistance Publique - Hôpitaux de Paris · NCT07135765 · Data updated 2026-11-12
We will use a short, extra high-resolution MRI to see if differences in the deep back muscles are linked to scoliosis in children aged 10–17 with idiopathic or neuromuscular forms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 10 Years to 17 Years |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Garches) |
| Status | Recruiting |
| Started | July 17, 2025 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | August 22, 2025 |
| Trial ID | NCT07135765 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and adolescents aged 10–17 with non-collapsing idiopathic or neuromuscular scoliosis, Cobb angle under 40°, who are ambulatory, MRI-compatible, and have parental consent are ideal candidates.
✕Probably not a fit
Patients with prior spinal surgery, collapsing scoliosis, Cobb angle ≥40°, inability to undergo or cooperate with MRI, or who are non-ambulatory are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, comparative, non-randomised single-center imaging project enrolling children with idiopathic or neuromuscular scoliosis who require spinal MRI. Participants undergo an additional five minutes lying in the scanner to acquire high-resolution images of the deep paravertebral muscles (multifidi and rotatores). The study compares muscle morphology between idiopathic and neuromuscular scoliosis and between the convex and concave sides of the spinal curve. The aim is to identify morphological patterns that could indicate a subgroup of idiopathic scoliosis patients whose onset or progression relates to muscle dysfunction.
Why it matters
Potential benefit: If specific muscle changes are identified, this could point to new targets for physical therapy or other interventions to slow or prevent scoliosis progression.
How similar studies have gone: Previous MRI studies have reported muscle asymmetry in scoliosis, but high-resolution paravertebral muscle imaging as a phenotyping tool is relatively novel and not yet proven to change clinical care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children and adolescents aged 10 to 17 years old, * Scoliosis (idiopathic or neuromuscular) that is not collapsing * Cobb angle \<40° * Female preferred * Patient able to walk * Average or low BMI \<20kg/m2 * Signature of informed consent by legal guardians * Affiliation with a social security scheme (beneficiary or dependent). Exclusion Criteria: * Refusal of the patient and/or parents to participate in the study * Inability to cooperate * Subject with a contraindication to MRI * History of spinal surgery * Not affiliated with a social security scheme (beneficiary or entitled person)
Where it's running
-
CHU Raymond Poincaré - APHP
Garches, France Recruiting
Study contacts
- Principal investigator: Hélène Gouz, MD — CHU Raymond Poincaré - APHP
- Study coordinator: Hélène Gouz, MD
- Email: helene.gouze@aphp.fr
- Phone: +33149094674
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.