Susac Syndrome: common features and possible causes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, single-center project that enrolls adults with at least two features of the Susac triad (encephalopathy, audiogram-confirmed cochlear damage, or retinal artery branch occlusion). Investigators will compile detailed clinical histories, brain MRI findings, audiograms, retinal imaging (fundoscopy/fluorescein angiography), cerebrospinal fluid and routine laboratory results to define epidemiological, phenotypic, and etiological patterns. No experimental treatments are given; the work is intended to better characterize how the disease presents and progresses. The aim is to create a more complete clinical picture to improve recognition and future research directions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years of age
* Patient presenting with at least two of the signs of the clinical triad: encephalopathy, cochlear damage authenticated by an audiogram (uni- or bilateral, predominantly in the middle or low frequencies), retinal artery occlusion assessed by fundoscopy or fluorescein retinal angiography.

Exclusion Criteria:

* Patient having been individually informed and objecting to the use of his/her data
* Patient under legal protection (guardianship or curatorship)
* Differential diagnosis established: multiple sclerosis, mitochondriopathy, CADASIL, primary tumour of the central nervous system, Lyme disease.

Where it's running

• Hôpital Bichat
  Paris, France Recruiting

Study contacts

• Principal investigator: Karim Sacre, MD, PHD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Karim Sacre, MD, PHD
• Email: karim.sacre@aphp.fr
• Phone: +33140258705

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.