Assessing venous congestion in ARDS patients using ultrasound

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine the prevalence of venous congestion in patients with acute respiratory distress syndrome (ARDS) using venous Doppler ultrasound and the Venous Excess Ultrasound Score (VExUS). It will involve adult patients admitted to the intensive care unit who require mechanical ventilation and catecholamine support. The primary outcome will measure the proportion of patients with a VExUS score of 1 or higher within 48 hours of starting invasive mechanical ventilation, while secondary outcomes will evaluate the association of VExUS grades with major kidney events at 30 days. The study seeks to improve the understanding of venous congestion's role in acute kidney injury among ARDS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥18 years old
* Moderate to severe ARDS according to the Berlin definition
* Requiring catecholamine support
* Undergoing invasive mechanical ventilation for less than 48 hours

Exclusion Criteria:

* Patients presenting with acute kidney injury KDIGO III requiring renal replacement therapy before the initial ultrasound evaluation
* Requirement for veno-venous or veno-arterial ECMO circulatory support before inclusion
* Patients with end-stage chronic kidney disease, on dialysis, and/or kidney transplant recipients
* History of Child C cirrhosis and/or liver transplantation and/or portal hypertension
* History of portal thrombosis
* Known history of pulmonary hypertension
* Pregnant women
* Patients under legal protection
* Patients who have expressed opposition to participating in the research

Where it's running

• Armand MEKONTSO DESSAP
  Créteil, Val de Marne, France Recruiting

Study contacts

• Study coordinator: Romain ARRESTIER, PHD
• Email: romain.arrestier@aphp.fr
• Phone: + 33 1 45 17 85 06

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.