Which parts of the immune system protect adults with major burns from fungal infections
Official title: Determining Elements of Anti-Fungal Immunity in BURN Patients
Run by Assistance Publique - Hôpitaux de Paris · NCT06828458 · Data updated 2026-11-12
This research will test whether patterns in patients' immune systems explain why some adults with serious burns develop invasive fungal infections and others do not.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 327 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 23, 2025 |
| Main results expected | October 23, 2030 |
| Study ends | October 23, 2030 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT06828458 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with major burns (≥15% total burn surface area) admitted within four days of injury who consent (or whose relatives do) and have health insurance affiliation are eligible.
✕Probably not a fit
Patients who are pregnant, who refuse participation, who have a decision to limit or stop active therapies, or who have smaller burns (<15% TBSA) are not eligible and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational cohort of adult burn patients admitted within four days of injury with total burn surface area of at least 15%, conducted at Hôpital Saint Louis AP-HP in Paris. Researchers will collect biological samples (blood and related specimens) over the hospital course to measure humoral and cellular antifungal immune responses. Immune profiles will be compared between patients who do and do not develop invasive fungal disease to identify immune features linked to risk. The protocol excludes pregnant patients, those who refuse participation, and patients with orders to limit or stop active therapies.
Why it matters
Potential benefit: If successful, the work could identify immune markers that help predict which burn patients are at high risk for invasive fungal infections and guide preventive or targeted therapies.
How similar studies have gone: Previous observational cohorts in burn patients have documented high rates of invasive fungal disease and highlighted gaps in understanding antifungal humoral immunity, so this approach builds on prior findings but focuses on a less-studied immune component.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Burn patients * Adult patients ≥ 18 years old * Admission \< 4 days following burn injury * Total burn surface Area ≥ 15% * Non opposition of the patient or his/her relatives to the research * Affiliation to social security or any health insurance Exclusion Criteria: * Pregnancy * Opposition of the patient or his/her relatives * Decision not to resuscitate or to limit or stop active therapies
Where it's running
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Hôpital Saint Louis AP-HP
Paris, France Recruiting
Study contacts
- Study coordinator: Emmanuel Dudoignon, MD
- Email: emmanuel.dudoignon@aphp.fr
- Phone: 1 42 49 93 94
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.