Skin and gut microbiome study in Netherton syndrome
Official title: Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome
Run by Assistance Publique - Hôpitaux de Paris · NCT07280091 · Data updated 2026-11-12
This study tests whether the skin, gut, and oral microbiomes differ in people with Netherton syndrome compared to those without the condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 10 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris, Île-de-France Region) |
| Status | Recruiting |
| Started | May 26, 2026 |
| Main results expected | May 2028 |
| Study ends | May 2028 |
| Registry record updated | June 30, 2026 |
| Trial ID | NCT07280091 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are adolescents and young adults with genetically or clinically confirmed Netherton syndrome and age-matched controls without skin barrier impairment.
✕Probably not a fit
Participants without Netherton syndrome or those unable to provide the required samples may not directly benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will collect superficial skin swabs, stool, saliva, and blood samples from adolescents and young adults with Netherton syndrome and from matched controls to compare microbiome and mycobiome profiles. Researchers aim to identify correlations among skin, gut, and oral microbial communities and their possible links to the disease features. The study does not involve an intervention or treatment, and findings will inform understanding of how barrier impairment and allergic manifestations relate to microbiome composition.
Why it matters
Potential benefit: If successful, findings could improve understanding of Netherton syndrome and guide future microbiome-targeted approaches.
How similar studies have gone: Prior research has shown microbiome alterations in Netherton syndrome patients, supporting the relevance of this type of observational analysis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Group A: * Children aged 10 years and older and adults with confirmed Netherton syndrome diagnosed at age 10 years or older (clinical and histological and/or molecular) * Patients and legal guardians informed about the study and not opposed to participation in the study Group B: * Children aged 10 years and older and adults with no skin barrier impairment, dermatosis, inflammatory disease, or autoimmune disease. * Subjects and legal guardians informed about the study and who do not object to participation in the study. Exclusion Criteria: * Refusal by parents/guardians, children, adolescents, or adults. * General or local antibiotic therapy within the month preceding the consultation.
Where it's running
-
Hôpital Necker Enfants Malades
Paris, Île-de-France Region, France Recruiting
Study contacts
- Study coordinator: Christine BODEMER, PhD
- Email: christine.bodemer@aphp.fr
- Phone: 01 44 49 46 72
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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4% QRX003 lotion for Netherton syndrome skin
This trial will test whether applying 4% QRX003 lotion twice daily for 12 weeks improves skin symptoms in people aged 4 and older with Netherton syndrome.
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QRX003 4% lotion for people with Netherton syndrome
This trial will try QRX003 4% lotion applied twice daily to affected skin to see if it improves symptoms in people aged 14 and older with Netherton syndrome.
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Evaluating QRX003 lotion for treating Netherton Syndrome
This study is testing a new lotion called QRX003 to see if it can help people with Netherton Syndrome feel better when used with their regular treatments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.