Memory abilities in people with disorders of consciousness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses bedside high-density EEG and ECG with two auditory protocols to probe perceptual, episodic, and autobiographical memory processes in ICU patients who have a disorder of consciousness. It targets both encoding (memory formation during the DoC) and retrieval (memory reported after recovery) and compares physiological markers during unconscious periods with subjective reports after patients regain consciousness. Participants include non-communicating DoC patients, conscious ICU controls, and patients who recovered consciousness, with data supplemented by semi-structured interviews and psychological scales. The aim is to produce a nuanced profile of memory capacities across types and time windows.

Why it matters

Who can join: the full rules

Inclusion criteria

Patients suffering from a Disorder of Consciousness:

* Patient not conscious according to the CRS-R scale (Kalmar \& Giacino, 2005)
* Age over 15 years and 3 months
* Free and informed consent signed by a third party (parental authority, trusted support person)

Conscious patients (controls) :

* Age over 15 years and 3 months
* Cared for in an Intensive Care Unit
* Free and informed consent signature

Patients who have regained consciousness after having suffered from a Disorder of Consciousness (if not included during their disorder):

* Age over 15 years and 3 months
* Free and informed consent signature if able, otherwise signature of relative (holders of parental authority for minors)
* Patient who has been unconscious for at least 3 days according to the CRS-R scale Exclusion criteria: - Deep sedation (Intracranial hypertension, refractory status epilepticus)
* Previous severe neurodegenerative disease (e.g. Alzheimer's disease, Lewy body dementia)
* Deafness
* Patients under guardianship or trusteeship
* Pregnant and breast-feeding women

Where it's running

• APHP, Pitié-Salpêtrière Hospital, Department of Anesthesia and Intensive Care, NeuroSurgery ICU
  Paris, France Recruiting
• APHP, Pitié-Salpêtrière Hospital, Department of Neurology, Neuro-ICU
  Paris, France Recruiting

Study contacts

• Principal investigator: Benjamin Rohaut, MD PhD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Benjamin Rohaut, MD PhD
• Email: benjamin.rohaut@icm-institute.org
• Phone: 01 84 82 78 88

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.