Immune mechanisms in acute respiratory distress syndrome in ventilated ICU patients.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls adults with ARDS receiving invasive mechanical ventilation in the ICU and profiles circulating inflammatory biomarkers to define inflammatory subphenotypes. Investigators obtain pulmonary immune cells (likely via bronchoalveolar sampling) and perform single-cell RNA sequencing to capture cell-specific transcriptomes. They then correlate serum biomarker patterns with lung immune cell gene-expression profiles to identify distinct biological endotypes. The goal is to better understand pathophysiological mechanisms that underlie heterogeneous ARDS presentations and inform more targeted therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ARDS risk factors: bacterial or viral pneumonia, extrapulmonary infection, major trauma, transfusion, inhalation injury, or shock.
* Pulmonary edema not explained by a cardiogenic cause or volume overload.
* Onset of respiratory symptoms within \<7 days.
* Bilateral pulmonary involvement on chest X-ray, CT scan, or ultrasound.
* PaO₂/FiO₂ ≤ 300 assessed with PEEP ≥ 5 cmH₂O.

Exclusion Criteria:

* ARDS with intubation for more than 48 hours.
* Contraindications to bronchoscopy: effective anticoagulation, dual antiplatelet therapy, thrombocytopenia \<50 G/L.
* Pre-existing immunodeficiency: active solid tumor or remission \<5 years, active hematologic malignancy or remission \<5 years, systemic disease (even without specific treatment), solid organ or bone marrow transplant, HIV infection with CD4 \<200/mm³.
* Cardiac arrest with a poor prognosis (NSE \>60, malignant EEG, diffuse ischemia on imaging, loss of trunk reflexes).
* Patients \<18 year-old
* Patients under legal guardianship, curatorship, or deprived of liberty.
* Ongoing pregnancy.
* Patients without social security coverage.

Where it's running

• Hôpital Lariboisière
  Paris, France Recruiting

Study contacts

• Study coordinator: Pierre-Louis BLOT, MD
• Email: pierre-louis.blot@aphp.fr
• Phone: +331049956565

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.